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606,025 grants found
Showing 19,601 – 19,620 of 606,025 grants
Correlate of Protection against Paratyphoid (CoP-PT)
There is a huge global burden of enteric fever which disrupts the lives of children in settings with inadequate quality water and poor sanitation and it kills.Through our series of...
Sustaining Political Ambition for Action on AMR
This proposal builds upon antimicrobial resistance (AMR) advocacy efforts that the UN Foundation has undertaken in partnership with the Wellcome Trust over the last 10 months.Enabl...
Rift Valley Waters: Indigenous-Led Research on Climate Change and Health in Lake Turkana and Lake Bogoria
Climate change is impacting water resources and ecosystems globally, with severe consequences for Indigenous communities with deep cultural ties to their lands.We propose a Communi...
Neural circuits and computations of flexible navigation
Identifying and navigating to spatial locations important for survival, such as food sources, is crucial for animals. Previous work has described in detail how the mammalian brain...
Earlier diagnosis in women at high risk of breast and ovarian cancer
Background Recent advances allow tiny amounts of cancer-derived DNA and proteins to be detected in blood.These have been utilised to develop commercial cancer screening tests for t...
Transposable Element Activation in Pre-invasive and Early Invasive Breast Cancer Development in High-Risk Women: Developing a Spatial Proteogenomic and Liquid Biopsy Platform for Molecular Characterization and Early Detection
Background Women carrying germline BRCA1/2 mutations (gBRCAm carriers) have a 75% lifetime risk of developing breast cancer (BC). There is a need for additional biomarkers to predi...
Cancer surgery at systems medicine level: simultaneous molecular mapping and resecting of solid tumours using spectroscopically guided semi-autonomous surgical robots- SU2C
In spite of the tremendous progress in cancer biology and the development of targeted drug therapies still >80% of curative interventions are surgical in case of solid tumors.Wh...
Mapping intestinal metaplasia progression across the upper gastrointestinal tract through a common precancer lens
Intestinal metaplasia is a precancerous condition that occurs in the oesophagus (known as Barrett's oesophagus, BO) and stomach (known as gastric intestinal metaplasia, GIM),...
CRUK Children's Brain Tumour Centre of Excellence 2024
Almost no new treatments of childhood brain tumours have been developed in over 50-years: these diseases continue to kill more children than any other cancer.Therefore, in 2018 we...
CRUK Cambridge Clinical Academic Training Programme / Year 1 QQ2
The Vision of our Clinical Academic Training Programme (CATP) is ‘To be the international Centre of choice for clinicians seeking doctoral training in the cancer sciences’.Our miss...
Associations between androgen deprivation therapies and adverse cardiovascular outcomes in men with prostate cancer: a population-based cohort study in England
Background: >500,000 men are living with or beyond a prostate cancer (PC) diagnosis in the United Kingdom.Cardiovascular disease (CVD) is a leading cause of mortality in PC surv...
Developing evidence and theory-informed digital videos employing a user-centred participatory approach, to support the early detection of skin cancer (EDSC) via self-examination of the skin (SSE), focused on at-risk (older men) and under-served populations (‘people of colour’)
Background More people are getting skin cancer and dying from it; climate change may drive this further. People are likely to live longer with better prognosis if cancer is diagnos...
Exploiting pyrimidine metabolism as a cancer prevention and intervention strategy
Background: In the earliest stages of premalignant progression, changes in the microenvironment play a key role in supporting tumour initiation. These favourable environments prime...
Use of spatial proteomics to dissect an emerging inflammatory pathway for targeted cancer prevention
Background Chronic inflammation is a hallmark of ageing and a major cause of age-related cancer.A key contributor is the milieu of factors secreted by senescent cells known as the...
QuanTOR – Quantitative Analysis of Textual Organisation across Registers
stylistics
Collaborative Research: Was early Cenozoic Samoa and Rarotonga volcanism suppressed when the Ontong Java Plateau drifted over the hotspots?
Oceanic hotspot tracks form when plumes of hot rock upwell from the deep mantle and melt. Approximately 60 million years ago the Ontong Java Plateau (OJP) moved over the Samoan and...
Collaborative Research: Elements: FaaSr: Enabling Cloud-native Event-driven Function-as-a-Service Computing Workflows in R
This project develops FaaSr, a new software that will facilitate the programming and deployment of scientific computing applications written in the R language in Function-as-a-Serv...
Preparing for the Future of the STEM Teacher Workforce in the 21st Century: Leveraging Multi-contextual Evidence
This project aims to identify trends in the demographics and turnover behavior of the STEM teacher workforce. It focuses on specific remedies and investments needed to retain prosp...
STORYLINK: Bridging Knowledge Gaps Between Swiss and Albanian Communities in Switzerland Through Creative Biographical Writing
inter-cultural communication
Collaborative Research: SaTC: CORE: Medium: Securing Interactions between Driver and Vehicle Using Batteries
The goal of this project is to develop a novel vehicle theft protection called BVI (Battery-based Vehicle Immobilizer). The project’s novelties lie with the use of 12/24V automotiv...