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Wasserstein FLOW Learning for multi-Omics
Single cell molecular profiling allows to map cellular development at an unprecedented level of detail.Optimal transport (OT) enables the analysis of this dynamical process as a tr...
Next-generation red cell analysers for blood-banking, transfusion medicine, and haematological diagnosis
Tissue O2 delivery is essential for life and rate-limiting for activities.Its maintenance is paramount in medical conditions ranging from critical care to anaemia, and a common cor...
Spin glasses and random polynomial systems: structure, algorithms and connections
The project focuses on two areas in the study of random functions in high-dimensions: mathematical Spin Glass theory and random systems of polynomial equations. Research in these f...
Symbiotic interactions at the origin of eukaryotes
Recent advances in environmental microbiology, metagenomics and phylogenomics strongly suggest that the eukaryotic cell evolved from symbiotic consortia involving an Asgard archaeo...
Succinct Cryptographic Proof Systems: Theory and Practice
A proof system allows a power prover to convince a weak party (the verifier) of the validity of large computations. Proof systems are a powerful and versatile tool that is central...
The transcriptional regulation of cardiomyocyte polyploidization and its relevance in cardiac regeneration
The mammalian heart is a non-regenerative organ due to the extremely limited ability of fully differentiated cardiomyocytes (CMs) to proliferate.While neonatal hearts still contain...
A novel approach for studying biological proton transfer: Protein incorporation of noncanonical amino acids carrying a light-triggered proton donor and proton acceptor
Proton transfer (PT) reactions within proteins are fundamental in biological systems, such as within ATP production.To date, there are no direct means to measure specific PT pathwa...
Autoxitus: Molecular mechanisms and non-cell autonomous signalling
Cells control their content by balancing its synthesis and degradation.Autophagy is a key degradation process capable of engulfing large fractions of cells, including organelles, i...
Vascular Control of NASH Progression
Non-alcoholic steato-hepatitis (NASH) is a major risk factor for hepatocellular carcinoma (HCC), the 6th most common cause of cancer-related death worldwide.The transition among di...
Brownian particles in nonequilibrium baths
The power of thermodynamics comes at the expense of certain assumptions and idealizations. An important premise is the concept of a thermal bath which is in contact with the examin...
Revealing the mechanics of sub-critical rock cracking of mountains cliffs from environmental forcings by imaging stress cycles from dense acoustic arrays
The general idea that a rock mass cracks when the external stress-loading exceeds the rock strength, leading to catastrophic failure (critical cracking), is challenged when conside...
Mutations of mtDNA - inheriting without perishing
Mutations of mtDNA cause mitochondrial diseases and are heavily implicated in the pathophysiology of age-associated diseases and ageing.Low levels of mtDNA mutations are universall...
WEARABLE ULTRASOUND FOR CONTINUOUS BLADDER MONITORING
Millions of people worldwide suffer from lower urinary tract dysfunction (LUTD), which costs billions of dollars in medical expenses due to a lack of reliable continuous monitoring...
Mapping the Connectome Dynamics of Trauma Psychopathology
Exposure to a traumatic event can induce psycho-physiological reactions and symptoms that in most people recede over time.A minority of trauma-exposed individuals develop posttraum...
How do cells form an embryo: Intracellular, temporal, and phenotypic dissection of mammalian gastrulation
In multicellular orIn multicellular organisms, how variation is achieved while cells comprise identical genetic information represents a fundamental open challenge my group strives...
Comprehending Human Action using Social Networks
This proposal consists of three interconnected projects that study how social networks shape the behavior of 1) scientists, 2) politicians, and 3) citizens by using the structure o...
SAfeguarding female FERtility -development of human-relevant in vitro tools for reproductive toxicity
Chemical health risk assessment has failed to safeguard fertility in women.Women and their oocytes are exposed to pervasive mixtures of human-made chemicals that correlate with rep...
CertiFOX: Certified First-Order Model Expansion
The field of combinatorial optimization is concerned with developing generic tools that take a declarative problem description and automatically compute an optimal solution to it....
Systemic Effects of Crises on Policy-Making in Modern Democracies
CRISPOL analyzes the systemic impact of crises on democratic policy-making.The fact that crises have turned into ordinary rather than exceptional phenomena in modern democracies ma...
Gravitational wave detectors cooled with superfluid helium
GRAVITHELIUM addresses the central technology challenge in third generation gravitational wave (3G GW) detectors, proposing to cool the core optics of cryogenic detectors with supe...