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606,025 grants found
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DNA damage deficiency in prostate cancer: functional characterisation and treatment
Sequencing profiling studies of prostate tumours have identified common alterations in genes involved in DNA damage response. Up to 10% of patients with aggressive disease show ATM...
Determination of the nature and role of the M1 and M4-muscarinic acetylcholine receptor network in regulating neuro-physiology
This PhD programme aims to address a major barrier in the development of novel treatments for Alzheimer's disease (AD).Activators of the muscarinic family of G protein-coupled...
Enhanced carbon export driven by internal tides over the mid-Atlantic ridge (CarTRidge)
Plankton in the ocean, microscopic plants (phytoplankton) and tiny animals (zooplankton) that eat the plants, are vital to marine life and to Earth's climate. They form the ba...
Global Music Technologies: Collaboration and Cultural Exchange
The history and development of musical instruments is a rich and diverse but much overlooked part of our cultural heritage. Intrinsically linked to creative expression, musical ins...
Investigating the Regulation and Replication of R-loops at Telomeres
Eukaryotic chromosomes are capped at each end by specialised nucleoprotein structures called telomeres, which are mutated or altered in essentially all incidences of cancer.Telomer...
Characterisation of adenovirus vector vaccine particles for improved antigen delivery
Doctoral Training Partnerships: a range of postgraduate training is funded by the Research Councils.For information on current funding routes, see the common terminology at https:/...
Development Of Advanced Computational Techniques To Study Next-Gen Evtol Aircraft Configurations
A promising new solution to providing a means of zero-emission transport is the eVTOL (electric Vertical Take-Off and Landing) vehicle.These new vehicles have the ability to operat...
LMO1 intracellular antibody fragments for delivery in improved treatment of childhood neuroblastoma
The LIM-only protein LMO1 is implicated in neuroblastoma by synergising with MYCN to promote tumour development and metastasis.The proposed work will use technologies we developed...
Moustachioed Women: A digital humanities investigation into the politics of female facial hair in literature, 1835-1906.
This project examines what the literary representations of moustachioed women between 1835-1906 reveal about the history and politics of facial hair that have remained prevalent to...
Computing Lagrangian means in multi-timescale fluid flows
Time averaging is one of the most essential tools in analysing fluid flows with multiple time scales, which are ubiquitous in nature and industries. A prominent use of time averagi...
Bioharmonophores imaging
In this project, we will establish a smart diagnostic probe that utilises the well-known advantages of PSMA-PET tracers with the self-assembly properties of tripeptides that form t...
STRESSORS: Monitoring and Assessment of Urban Nature-based Solutions
Urban green infrastructure (UGI) and Nature-based Solutions (NbS) are sustainable solutions to managing urban flood risk whilst offering additional co-benefits (i.e. pollution cont...
Examining the mechanism of chromatin replication and assembly at telomeres
Each human telomere is composed of 10-15 kb of repetitive DNA bound by a protein complex called shelterin, which forms a protective nucleoprotein cap at the chromosome end. In addi...
Investigation of the cancer cell membrane proteome to find new vulnerabilities in non- small cell lung cancer
The surface proteome of non-small cell lung cancer (NSCLC) cells expresses specific pairs of proteins, which can be used as targets for delivering cytotoxic agents (e.g. antibody d...
Determining the role of Cyclin B2 in Genomic Stability
Mitosis is controlled by the major mitotic kinase CDK1 and its regulatory partner, Cyclin B. There are two B-type cyclins in vertebrate cells: Cyclins B1 and B2. Cyclin B1 is essen...
Developing partial system models to assess system-level resilience to perturbations: determining the resilience of pollinator networks
Developing partial system models to assess system-level resilience to perturbations: determining the resilience of pollinator networks to climate change
Beyond 'support': Exploring the use of participatory action research to propose strategies to reduce inequalities in the outcomes and experiences of S
This proposed research has an overall objective to explore how Participatory Action Research (PAR) could contribute to understanding and meeting the needs of Students on Low Income...
Travel Grant 2024 Japan, Innovation Talk October 8
Purpose and goal:Japan is an important market for AAX Biotech, as our target customers are pharma and biotech companies. AAX Biotech’s CEO, Maria L. Knudsen, will be presenting at...
Mapping healthy ageing in whole Drosophila with the Mesolens
An ageing global demographic with increased multimorbidity is arguably the greatest challenge facing 21st-century health care systems. Understanding the biological underpinnings of...
Disrupting Flood Risk Management Narratives: Youth-Centred Research into Education, Action and Resilience in Flood Affected Places
Across the UK, as the effects of anthropogenic climate change become more apparent, flood risk is increasing, with 1 in 6 properties now considered vulnerable, up from 1 in 8 (EA,...