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606,025 grants found
Showing 11,481 – 11,500 of 606,025 grants
eMB: Prediction of keystone viruses in natural microbiomes via transient dynamics modeling
Viruses play a crucial role in ecosystem dynamics by infecting bacteria, with nearly half of all bacteria being infected at any given time. Despite the importance of viruses, most...
The planning and pilot study of MISSION-O - Menopausal impact of opportunistic salpingectomy for prevention of ovarian cancer
Opportunistic salpingectomy (OS) is advocated to prevent epithelial ovarian cancer.The national "Hysterectomy and Opportunistic Salpingectomy" (HOPPSA) trial evaluates su...
Kartläggning av HIV-reservoarer för ART-avbrott och botstudier vid kronisk HIV-infektion: CHART-C-studien
Current HIV cure trials primarily focus on people living with HIV (PLWH) who started antiretroviral therapy (ART) during the primary infection stage, as they are known to have smal...
Does SGLT-2 inhibitors improve the prognosis for patients on dialysis?
The aim is to analyze the effect of SGLT-2 inhibitors on cardiovascular outcomes for patients on dialysis.Patients on dialysis have a high risk of cardiovascular disease and death...
NArrow compared to broad-Spectrum antibiotics for treatment of Community-Acquired Pneumonia – the NASCAP study
The aim is to optimally design a non-inferiority randomized clinical trial (RCT) that compares empirical narrow-spectrum with broad-spectrum beta-lactam antibiotic treatment of non...
Malaria treatment outcomes in travelers- addressing emerging drug resistance
Malaria is a potentially severe and fatal disease. Artemisinin combination therapy (ACT) is the first line therapy for malaria. Alarming emergence of resistance to artemisinin and...
Selenium Intervention Pilot and Feasibility Study in Heart Failure (SIP-HF)
The SIP-HF aims to prepare for a large-scale trial on selenium supplementation´s efficacy in heart failure (HF) patients.Objectives include finalizing the study design, securing ap...
SPRINTR – Swedish PRostate cancer Initiative for Novel Treatment Regimens Biomarker driven precision medicine in non-metastatic high-risk prostate cancer
Yearly, 2100 Swedish men die from prostate cancer (PC).About 50 % of these were first diagnosed with non-metastatic high-risk PC (HR-PC) and offered curative treatment that failed....
Antiviral treatment of Tick-borne encephalitis TBE - setup of a national multi centre clinical trial
The aim of this application is to design and set-up a Swedish multicentre clinical trial to investigate the efficacy of an anti-viral treatment for patients with Tick-borne Encepha...
Swedish Cardiac And Renal Failure Study-1 (SCARF-1) A randomized open label study of eplerenone vs usual care in patients with heart failure with reduced ejection fraction and reduced kidney function
Background Heart failure (HF) is a common disease with high mortality and morbidity especially in combination with severe chronic kidney disease (CKD). Virtually all major studies...
Development of a data-driven treatment protocol for musculoskeletal pain and overuse symptoms in upper limb amputees – a planning phase for a national collaboration
The project purpose is to form a national collaboration to treat musculoskeletal pain and overuse symptoms in upper limb (UL) amputees.The project aims to (i) map and perform a com...
Sleep EEG and presymptomatic Lewy body pathology in Alzheimer´s disease: implications for treatment decisions
Alzheimer`s disease (AD) has different clinical and biological subtypes, which is reflected in the heterogeneity of initial symptom profiles and different trajectories of decline....
Molecular tissue perturbations and trajectories in people with obesity undergoing weight cycling during medical- and surgical versus lifestyle interventions - an observational clinical trial
Game changing improvements in obesity treatment have been achieved in recent years with both bariatric surgery and GLP1-based medicines.However, all current obesity treatments are...
Fast Assessment and Speedy Treatment of NSTEMI (FAST-NSTEMI)
Purpose: In a registry-based randomized clinical trial (R-RCT), we aim to determine if immediate invasive strategy with coronary angiography and percutaneous coronary intervention...
Design of clinical studies to evaluate immune responses induced by RSV vaccination in elderly and immunosuppressed individuals
Respiratory syncytial virus (RSV) is a leading cause of respiratory infections, particularly in infants, the elderly, and immunosuppressed individuals, resulting in significant hos...
Targeting SAMHD1 in relapsed/refractory AML: The FLAsH-IV-AML trial
Relapsed/refractory acute myeloid leukemia (R/R AML) is a devastating disease with median survival < 6 months. There is an urgent need to develop more potent salvage therapi...
Non-invasive brain stimulation to treat intractable anxiety in young autistic individuals
The proposed study aims to evaluate the efficacy and safety of a new non-invasive transcranial stimulation, temporal interference (TI) stimulation, for treating intractable anxiety...
Bolivian Amazon SEasonality (BAMSE)
Seasonality affects the occurrence of droughts, floods, and extreme events by regulating the distribution of rainfall over the year.Future projections suggest enhanced seasonality,...
Optimal recovery from attacks against cyber-physical systems
The rising frequency of cyber attacks necessitates automated attack recovery.This project will address this need by framing attack recovery for cyber-physical systems as a dynamic...
Elucidating the role of gut microbially produced hydrogen sulfide in metabolic flexibility and aging
A hallmark of aging is the decline in the ability to adapt to nutrient availability (metabolic flexibility). While gut microbes are linked to health, their role in aging is underst...