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Determining haematopoietic stem cell activity for biomedical discovery
Haematopoietic stem cells (HSCs) are a rare but incredibly important cell type.Just ~100,000 HSCs generate all the cells of the blood and immune systems, which constitute 90% of th...
Learning to Operate T cells
T cells orchestrate immune responses crucial for the elimination of infections and cancers.They do this by initiating diverse effector responses when their T cell receptors (TCRs)...
Monocyte-to-Macrophage Trajectories After Lung Injury: Spatio-temporal investigation, molecular regulation & functional implications for lung regeneration and immunity (MoMacTrajectALI)
The lung is particularly exposed to airborne and blood-borne insults.The mechanisms underlying lung tissue repair are therefore of fundamental biological importance and have critic...
Activation and switch of fates in T lymphocytes. (ActSwiftly)
Antigen-stimulated naïve CD8+ T cells proliferate and differentiate into effector and memory cells. Whereas effector T cells remove infected or cancerous cells, memory T cells prot...
Evolutionary immunology: using insect models to unravel STING-dependent conserved and innovative antiviral strategies (Evo-immuno)
As we have seen with the emergence of viral pathogens like Ebola, ZIKA and SARS-CoV2, our societies are, and will continue to be, confronted to unknown and perilous viruses. To pre...
Symbioses between plants and sulfur-oxidizing bacteria sustain coastal 'blue carbon' ecosystems (SeaSym)
Sea- and saltmarsh grasses thrive along most of Earth’s coastlines.They form the basis for some of the most ecologically and economically valuable ecosystems on the planet that are...
Characterisation of Cardiovascular Disease in African youth with perinatally- acquired HIV infection in the era of antiretroviral therapy
Antiretroviral therapy has increased survival in people with HIV. Children with perinatally-acquired HIV are now reaching adulthood in growing numbers.It is becoming increasingly a...
Advancing precision medicine in heritable cardiac diseases: genetic insights from the understudied Middle Eastern population
Cardiovascular diseases (CVDs) represent the leading cause of mortality worldwide with >75% of CVD deaths occurring in low- and middle-income countries (LMICs).Genetic cardiomyo...
Reproductive Justice, Healthcare & History: Community Engaged Histories of Reproductive Health Care and Activism in Scotland and Alberta 1967-1990
Building on historical scholarship about reproduction, healthcare, and feminism, this project recognizes feminist groups and organizations as major players, alongside politicians a...
Neural circuit mechanisms for value-to-action transformation during economic decision-making
In economic decision-making, individuals make multi-attribute choices by computing and comparing expected values of different offers.For example, if presented with multiple lottery...
LEADing the way in dementia research: using AI to accelerate evidence synthesis and discovery
Despite substantial investment in dementia research, therapeutic options for patients remain limited.To facilitate the planning of new experiments and to inform decision making, th...
Learning to see; The brain as the next frontier in sight rescuing regenerative therapy
This program investigates the mechanisms of neuroplasticity essential for sight rescue after regenerative therapy.After decades of research on revolutionary ocular therapies but on...
Mechanisms of symmetry breaking at molecular and cellular scales in planar polarity
Symmetry breaking in biological systems is fundamental for pattern formation and elaboration of organismal complexity.In this proposal we seek multi-scale understanding of the symm...
Medicine without Doctors: Reimagining Care and Voice Through Play
Medicine without doctors is now a possible and plausible future for healthcare.Already encroached upon by commercial and scientific stakeholders, doctors’ roles in the UK have rece...
CAMMISA: Climate-focused Analytics and Modelling for Mosquito-borne Infections in Southern Africa
The widespread manifestation of climate change with trends in seasonality and extreme climate events have important implications for Mosquito-Borne Diseases (MBD).The transmission...
Disentangling a new paradigm for mutual homeostasis of aggregation-prone proteins
The dosage of proteins must be regulated in cells, especially for those containing low complexity domains (LCD-proteins) due to their propensity for condensation and aberrant aggre...
ENTHUSE – EvaluatiNg The High fat sUgar Salt rEgulations: practice, response and impact across retail settings
Background: Obesity and poor diet constitute two of the greatest threats to population health.The UK government introduced world-first Food (Promotion and Placement) regulations in...
Health, socioeconomic, and environmental risk factors for heat-related mortality and hospital admission in England
Background Climate change is causing increasingly frequent and intense heat events worldwide.In England, we are already witnessing the impact of extreme heat on population health,...
Investigating the multiple roles of cryptochromes in animal magnetoreception
Many species, including humans, are reported to be magnetosensitive. Indeed, some animals navigate using the weak magnetic field (MF) of Earth.Others do not, but there are accounts...
Data as a foundation for AI innovation and global discovery research in the life sciences
EMBL-EBI's data resources are a fundamental necessity for biomolecular research.Through open data, there is tremendous potential for accelerating scientific understanding and...