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Regulation of gene dosage on the mouse X chromosome
Differences in gene dosage can be as powerful as to drive species evolution (e.g., whole-genome duplications) and as harmful as to lead to human diseases (e.g., aneuploidies or hap...
Targeted Immunocytokines by CaGing and local Release
Immune therapies have caused a paradigm shift in the treatment of melanoma and leukemias. However, the broad Immune therapies have caused a paradigm shift in the treatment of melan...
The many faces of prejudice: the “What”, the “Why”, and the “How” of inferences we make from membership in social groups
Prejudice and discrimination have undeniable consequences for people’s lives and well-being.Our knowledge of stereotyping and prejudice is predominantly based on studies of simple...
Nanoengineered particles for enhanced cancer radiotherapy
Current cancer research efforts are focused on obtaining targeted therapies, with greater precision, that lead to improved patient survival, with fewer adverse effects to ensure a...
A territorialised Agricultural Knowledge and Innovation Systems framework for agroecological transitions
European food systems face sustainability challenges related to environmental degradation, nutritious and healthy sustainable food access, and just socio-economic development.Incre...
Nanoplatforms for Neuroscience
NeuroNanotech will train eleven researchers to tackle one of the major challenges in Europe’s ageing population - neurological diseases.The ability to monitor and modulate neural a...
Sustainable exploration and biodiscovery of novel products and processes from extreme aquatic microbiomes to expedite the circular bioeconomy
Microorganisms thriving in extreme environments are a largely untapped reservoir of enzymes, chemicals, and pharmaceutical compounds.Their unique metabolic pathways and regulatory...
Space-Time and Vectorial Meta-Optics for High-Power Structured Laser-Matter Interactions
Plasma is an extreme form of matter at the heart of important applications like fusion and particle acceleration.The creation and control of plasma require high-power lasers, now i...
Realizing designer quantum matter in van der Waals heterostructures
Conventional materials hosting exotic quantum phases typically have complex atomic structures, inhomogeneities from defects, impurities, and dopants making it difficult to rational...
SinGular Monge-Ampère equations
This project is driven by M-theory, String theory in theoretical physics and the Minimal Model Problem in algebraic geometry.We study singular Khler spaces with a focus on their sp...
Scientific Exchange to assess QUality and Risks of FOODs obtained by novel processing and Packaging Technologies
The goal of SEQUR FOOD is to build an international scientific network including researchers from EU and South America that will work on the development of novel food processing te...
Advancing Phage Therapy through Synergistic Strategies: Phage-Mediated Killing and Competitive Exclusion using Engineered Prophages
Amid the antibiotic resistance crisis, the century-old practice of phage therapy, the use of bacterial viruses to treat bacterial infections, has gained renewed attention. Despite...
A Systematic Exploration of Interreal Translations in the Media Multiverse
What will be the shape of the mediated reality to come?Current models include a single interconnected immersive metaverse, an increasing integration between physical reality and am...
Structure and Function-based Design of Vaccine Antigens and Antiviral Immunotherapies
Vaccines are critical in preventing viral diseases, and recent advances in vaccine development and delivery platforms have enhanced their reach and efficacy.Viral glycoproteins tha...
Catalytic Atroposelective Synthesis for Revealing Elusive Bioactive Conformations and Shapes
Atropisomeric molecules (atropisomers) are separable conformational isomers arising from restricted rotation around a single bond. Atropisomers have revolutionized the treatment of...
Sifting through the 3D Genome: Computational Models of Homology Search in DNA Repair
Homology-directed repair is an essential, evolutionary conserved DNA repair pathway that accurately restores genetic information lost due to double-stranded breaks.Its key step is...
OPTimising IndiGOidine production heterogeneity for sustainable microbial blue pigment biosynthesis
The textile industry is a major global contributor to environmental pollution, primarily due to the harsh conditions and hazardous chemicals used in fabric pre-treatment, dyeing, a...
Optoelectronic and all-optical hyperspin machines for large-scale computing
Efficient hardware for combinatorial optimization and machine learning impacts science, engineering, and society. With new computational models, photonics tackle problems intractab...
Ant navigation: understanding the resilience and self-developing nature of mini-brains in interaction with their environment.
Organisms differ from machines in their resilience: their capacity to spontaneously recover from defects.This is because organisms, contrary to machines, are self-developing system...
Revival of the Powerhouse: How mitochondrial remodelling controls the energy metabolism of the malaria parasite to enable survival in different hosts
The mitochondrion of the malaria agent Plasmodium falciparum is critical for parasite survival and a confirmed drug target.The dynamic organelle undergoes a Plasmodium-specific mem...