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199,248 grants found
Showing 7,581 – 7,600 of 199,248 grants
Spatio-molecular and functional interrogation of serotonin subsystems
Dysfunction of complex neural circuits is implicated in neuropsychiatric disorders such as depression. The serotonin system has long been linked to the etiology of depression, as w...
Transforming an innate structural fold into a drug targeting TLR-driven systemic inflammation
Excessive activation of Toll-like receptors (TLRs) due to unresolved infection and inflammation leads to destructive diseases, such as sepsis.Current treatments based on antibiotic...
Novel cancer chemotherapies targeting tumor-specific loss of genetic variation
The purpose of this project is to identify genetic variants that alone or in combination with hallmark chromosome level events during cancer development create drug-targetable vuln...
SUM-Safe: Scaling Up Midwife-led safer birth bundle of care through Quality Improvement in Ethiopia: a stepped wedge cluster randomized controlled trial study
The purpose of this proposal is to increase the level of evidence-based practices and increase the capacity for midwives to lead Quality Improvement (QI) initiatives in maternal an...
The Göteborg2 study; A prospective randomized, population-based prostate cancer screening study with PSA followed by MRI of the prostate
The aim of this project is to develop novel and improved screening algorithms for prostate cancer (PC). The project is motivated by two reasons. First, PC is the most common cause...
Complications during pregnancy and birth and offspring risk for schizophrenia and other psychoses: Untangling Causality and Genetic Influences.
Schizophrenia and related psychoses are associated with obstetric complications but whether these associations are causal is yet to be explored.This study investigates the relation...
Improving prediction and prognosis of multiple sclerosis; algorithmic approaches and biomarkers
Multiple Sclerosis (MS), a complex autoimmune disorder affecting mainly young adults, with a higher prevalence in women.Its diverse symptoms and inherent progression complexity hin...
Population-based studies of health risks associated with breast implants (BRISK)
Around 4% of middle-aged women have breast implants, the large majority for cosmetic reasons.There are rising concerns for adverse health effects of breast implants, yet comprehens...
Hur fungerar reglering av icke-specifika membranproteiner?
Many molecular programs in our body execute differently from binary on/off sensing (i.e. being dependent solely on the presence or absence of a single factor) but instead rely on i...
Federated Reinforcement Learning (FedRL): Algorithms and Theoretical Foundations
Recent advancements in single-agent reinforcement learning (RL) have set the stage for significant AI innovations. However, when it comes to systems with multiple agents, RL faces...
Targeting the c-MYC oncoprotein with stapled-peptides for cancer therapeutics
The oncoprotein c-MYC is a well-established target for anti-cancer therapeutics.However, it has been extremely challenging to develop a clinically viable drug against c-MYC because...
Gene engineering of the tumor microenvironment to induce sustained anti-tumor immunity in cancer patients
The aim of this project is to develop a new treatment for cancer based on a gene engineering vaccine.The field of gene engineering vaccines gained attention during the pandemic as...
Advancing Uterus Transplantation and Bioengineered Uterus: Current and Future Approaches to Treating Uterine Factor Infertility
BACKGROUND Infertility affects 15% of couples. By introduction of IVF and ICSI in 1980-90s most types of infertility could be treated. Absolute uterine factor infertility (AUFI) re...
The role of pallido-striatal neurons in sensory processing under parkinsonian and DBS conditions
The external Globus Pallidus (GPe) is a central part of the Basal Ganglia (BG), a group of subcortical nuclei supporting motor control and involved in movement disorders such as Pa...
The PEPP (PreEclampsia Postpartum Prevention) Trial: A postpartum intervention to improve cardiometabolic health in women with preeclampsia - a multi-centre randomised controlled trial
Preeclampsia (PE), a severe hypertensive disorder of pregnancy, is strongly associated with complications in subsequent pregnancy and early-onset cardiovascular diseases (CVD).Wome...
Modulating host macrophage functions to control latent tuberculosis - using helminth coinfection in high-endemic areas as a model
This project focuses on how chronic helminthic worm infections impair immune control of human tuberculosis (TB), and how current treatment strategies could be optimized to shorten...
Biofabrication of a Cartilage Microphysiological System (OA-on-a-CHIP) for Osteoarthritis Disease Modelling and Therapeutic Testing
Osteoarthritis (OA) is a chronic, progressive, degeneration of articular cartilage (AC) which affects >500 million people worldwide. The majority of research into OA uses no...
Biological principles of schizophrenia: adolescent cell type-specification and synaptic pruning in prefrontal cortex
PURPOSE AND AIMSSchizophrenia (SCZ) is a genetically complex and poorly managed disorder with a complicated pathology that generally manifests in early adulthood.With few exception...
Developing humour literacy: analysing production, content and reception of humour to bring positive change in the public sphere
The goal of the project is to find out how humour literacy can be used to reframe the conflicts and controversial issues in the public sphere and bring benefit to European society...
Targeting ER Import And Activation Of Viral Glycoproteins: Towards Broad-Spectrum Antivirals
The VIGILANT consortium is dedicated to tackling the global threat posed by emerging viruses, exemplified by the COVID-19 pandemic and the Ebola epidemic in Western Africa. These e...