The PEPP (PreEclampsia Postpartum Prevention) Trial: A postpartum intervention to improve cardiometabolic health in women with preeclampsia - a multi-centre randomised controlled trial

Preeclampsia (PE), a severe hypertensive disorder of pregnancy, is strongly associated with complications in subsequent pregnancy and early-onset cardiovascular diseases (CVD).

Women with PE also have an increased risk of CVD risk factors after pregnancy, with weight retention and overweight being key modifiable factors.

Thus, the postpartum phase provides a window of opportunity for implementation of screening and preventive strategies.The overall aim of this multi-centre two-armed single-blind parallel RCT is to assess the efficacy of a bundle intervention 3-12 months postpartum tailored for primiparous women with prior PE.

This includes information, targeted screening and promotion of a healthy lifestyle through support by healthcare personnel and a Smartphone-App.Population: Primiparous with PE (n=724)Intervention: A bundle intervention divided into: Light intervention 3-6 months postpartum and Intensive intervention 6-12 months postpartumControl: Standard careOutcomes: Primary: weight change over 9 months.

Secondary: 1) weight change over 9 months, stratified by early pregnancy BMI