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199,248 grants found
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ENTITLED: Elucidating the iNequaliTy gaps in burdens and access to mental health and substance use services in Sweden using IntersecTional and impLementation rEsearch Designs
ENTITLED examines the unequal distribution of common mental disorders (CMD) and substance use disorder (SUD) burdens and unmet needs of individuals requiring mental health and subs...
Vaccine-induced immunity and innovative epidemiological surveillance of respiratory infections in older adults
This project aims to improve surveillance of respiratory infections and optimize vaccine protection against respiratory infections to reduce disease burden among older adults.Objec...
Towards personalized risk prediction of cardiovascular disease
Aim: The aim is to develop improved screening strategies to cost-effectively identify at-risk individuals before they suffer ischemic heart disease (IHD).Work-plan: We use comprehe...
Targeting MYC and Metabolism in Childhood Neuroblastoma for Precision Medicine
Childhood neuroblastoma develops in the peripherical nervous system.Building on our previous work we will i) explore the antioxidant enzyme PRDX6 as target for tailored medicine f...
National increase and local variations in ADHD diagnoses - A mixed-methods study of school contexts
ADHD has increased more in Sweden than in almost any other country and now constitutes the single most common psychiatric disorder among children.Rates of ADHD also vary greatly wi...
What is good in higher education? An empirical ethics study of relational pedagogy
In the landscape of contemporary higher education, understood to have a pervasive culture of measurement, relational pedagogy emerges as a critical discourse challenging the observ...
From macroclimate to microclimate: Plant-soil microbial interactions and ecosystem carbon cycling under global change
Destabilized carbon (C) fluxes, caused by climate change, may shift forest ecosystems from C sinks to C sources.While we know that forest C cycling is largely driven by the activit...
SmellWell: Uncovering the overlooked link between farm animal olfaction and positive emotions
Olfaction and wellbeing are strongly linked in humans, and odours may be used to improve mental health.In [SmellWell], I will bring together the science of neurobiology and etholog...
FATTY ACID HOMEOSTASIS IN C. ELEGANS AND MAMMALS: PAQR-2/ADIPOR, HYPOXIA AND OTHER PATHWAYS
Fatty acids come in a variety of lengths and unsaturation and serve in energy storage, as structural components of membranes and as precursors of signaling molecules. Given their c...
Novel therapeutics for bone growth disorders targeting the growth plate
PURPOSE AND AIM: Abnormal bone growth is a very common problem.Many children with chronic diseases have impaired bone growth, others have leg length differences, or in rare cases e...
Infants and leukemia: understanding the mechanisms behind leukemogenesis in early life
Acute leukemia in infancy, i.e. children aged 0-12 months, is characterized by KMT2A-gene rearrangements (KMT2A-r), and a very poor outcome. The biological reason for this poor out...
Mechanistic studies on the effects of BTK inhibitors on tumor cells and micro-environment in chronic lymphocytic leukemia
The signaling cascade that triggers the B cell mediated immune-response upon antigen binding to the B cell receptor is critically dependent on Bruton’s tyrosine kinase (BTK). The B...
Data-driven precision medicine for improved antibiotic stewardship and infection control
Objective: To enhance infection control and antibiotic stewardship through data-driven precision medicine, utilizing advanced data science and machine learning for individualized r...
Understanding and preventing aging of the human heart
Diseases of the heart muscle and valves remain leading causes of death and disability globally, but their etiological spectrum has changed over time towards predominance of aging-r...
The gut-brain axis in the perinatal period: nausea, anxiety and depression
Pregnancy and the perinatal period present metabolic, immune and hormonal challenges to the body. Neurological symptoms are also common in this period, including nausea, the "...
Dissecting human ILC development and differentiation at the clonal level
Innate lymphoid cells (ILC), including NK cells, ILC1, ILC2, and ILC3, are involved in lymphoid tissue-development, infections, cancer, inflammation and tissue-repair. We have rece...
Pathways to adverse health development and increased healthcare consumption in patients with autism spectrum disorders – the role of individual factors and pharmacological treatment
The number of people diagnosed with autism spectrum disorder (ASD) in childhood or adulthood has strongly increased over the past decades.While research demonstrates that people wi...
Evaluating the compatibility of adaptive immunity and complex tissue regeneration
It remains an open question why select animals have the ability to regenerate complex multi-tissue structures (e.g., limbs). A longstanding theory in the field of regenerative biol...
Biomarkers to reform approaches to therapy-induced neurotoxicity (BRAIN), a substudy in the ALLTogether1 leukemia protocol
New treatments and international collaboration have led to survival rates >90% for pediatric acute lymphoblastic leukemia (ALL), but treatment-related toxicity is a problem....
Improving long-term outcomes of patients with severe mental disorder and comorbid cannabis use disorder
Cannabis use is increasing worldwide and also certain European countries plan to legalize or decriminalize cannabis. This will further increase use rates and also result into highe...