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199,248 grants found
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Harnessing astrocyte reactivity for precision medicine in amyotrophic lateral sclerosis
ALS is a highly heterogenous motor neuron disease.The ALS heterogeneity and consequently the challenge of patient stratification limit progress in clinical trials.Our goal is to pr...
Precision medicine in multiple sclerosis with diagnostic uncertainty
Multiple sclerosis (MS) is a debilitating disease mainly affecting young people and women.The cause of MS is largely unknown, and there are no biomarkers for diagnosing MS early, k...
The search for professional digital competence in Swedish teacher education – a qualitative multi-level project
Today´s Swedish society is permeated with digital technology including complex streams of (dis)information that may be algorithm-driven. This will require by young people to develo...
Adaptive separation of valuable molecules or particles using dynamically tunable nanofibril networks and porous structures
My research program will utilize dynamic nanofibril networks for adaptive separation of molecules and particles.Dynamically tunable membranes/gels would be groundbreaking for next-...
Pandemic situation awareness: towards trustworthy model-based epidemiological analysis
This proposal aims to develop computational approaches to address modeling challenges observed during the Covid-19 pandemic. Specifically, the project seeks to enhance data integra...
Harnessing unconventional T cells to understand tumor immunity and improve immunotherapy in colorectal cancer
Unconventional T cells, in particular mucosal-associated invariant T (MAIT) cells and gd T cells, have potent effector functions that may be relevant for tumor immunity.However, th...
Artificial intelligence-based multimodal prediction of peripartum depression: time for a paradigm shift
Every year, 16,000 women in Sweden suffer from peripartum depression (PPD)– depression during pregnancy or the first year after childbirth.PPD carries a sizable societal and econom...
Förbättring av pankreascancerdiagnostik genom mätning av telomerlängd hos individuella celler
Every time a cell divides, the ends of the chromosomes - the telomeres - become a bit shorter. This can be used to diagnose diseases related to cell division such as cancer.However...
Catalytic Antibiotics: Targeted protein degraders based on terpene natural products.
The pursuit of new antibiotics is one of almost unparalleled importance, seeing as the death toll for infectious diseases continues to rise.Traditional drug development based on sm...
Chasing traces of analyticity with applications to operator theory
My proposed investigation falls under the umbrella of research related to the uncertainty principle in Fourier analysis. The aim is to study the spectra, i.e.Fourier transforms, of...
Research careers in fragile contexts - The effects and potentials of doctoral education
The purpose of this research is to provide knowledge for PhD programs in North-South development aid partnerships on how to support graduates’ transitions to independent researcher...
Female phenotypic variation and intersexual mimicry as a bridge between micro- and macroevolution
Here, I will investigate the micro- and macroevolutionary dynamics of phenotypic variation and its effects on intra- and intersexual divergence and phenotypic diversification. Phen...
What triggers conformational change in proteins during the assembly of beta-sheet materials?
Some of the most fascinating materials in nature, such as spider silk, are built from proteins.The key to the extraordinary properties of silk is the hierarchical organization of t...
Understanding clonal hematopoiesis and initiation of myeloid malignancies
Clonal hematopoiesis often precedes the development of myeloid malignancies, but a majority of these individuals do not develop leukemia. Little is known of this tumor evolution.We...
Elucidating mito-cellular signaling to alleviate symptoms of mitochondrial disease
Mitochondrial diseases are a group of generally uncurable disorders with an often lethal outcome.Because mitochondria are essential for efficient energy production, the symptoms of...
Precision medicine models for sepsis-induced myocardial dysfunction
Myocardial dysfunction is one of the most severe manifestations of critically ill patients with sepsis, affecting 20-70% of this population.The absence of consensus criteria for th...
Coordination of cell shape acquisition during plant morphogenesis
Deciphering the precise mechanisms governing the formation of various cell types at specific time and space is a key challenge in developmental biology.This fundamental process und...
Think tank: Just Tech?
Purpose and goal:Just Tech?’s raison d´existence is the assertion that tech is entangled in the social and we need to create spaces for talking about and researching those entangle...
Unlocking Precision Medicine in Psychiatry: Targeting KAT III as a unique Concept for the Treatment of Immune-induced Cognitive Impairment and Psychosis.
The kynurenine pathway, generating neuroactive metabolites, plays a crucial role in mental processes. Excess of kynurenic acid (KYNA), driven by immune activation, triggers psychos...
Social health insurance in the Universal Health Coverage era: Does it impact health?
Low- and middle-income countries are adopting social health insurance as a mechanism for achieving universal health coverage.However, there is insufficient evidence on the causal l...