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199,248 grants found
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Mechanisms of tissue-specific disease tolerance in genotoxigenic bacterial infection
Disease tolerance, defined as limiting tissue damage without influencing pathogen load, is a component of the innate host response to infection.However, knowledge about the host me...
Studies of neutrophils in autoimmune joint inflammation
Neutrophils are the most abundant cells found in inflamed joints of patients with rheumatoid arthritis (RA), and animal models identify a central role for neutrophils in autoimmune...
Inequality and the Environment Beyond Homo Economicus
Inequalities measured in terms of income and wealth have increased substantially in recent decades, which has spurred a renewed interest in the measurement of inequality per se as...
Sustainimal 2.0
SustAinimal 2.0 will investigate roles of livestock for future increased, sustainable and competitive food production in Sweden.Focus will be on solutions for future food productio...
Personalized anti-fracture treatment
With increasing age of the population, Sweden and industrialized countries across the globe are facing a substantial increase in osteoporotic fractures, which account for considera...
CADASIL: Therapy development and novel biomarkers
CADASIL is the most common monogenic form of cerebral small vessel disease (SVD), a group of diseases affecting more than 5.000 individuals per year in Sweden.CADASIL is caused by...
The molecular portfolio of the extraocular muscles: keys to protection in muscle disease
The extraocular muscles (EOMs) are remarkably resistant to muscle dystrophies, despite having the same gene defect that affects all body muscles leading to severe handicap and prem...
Conquering forever chemicals: Simultaneous elimination of Per- and polyfluoroalkyl substances (PFAS) and their precursors from contaminated soil
Per- and polyfluoro-alkyl substances (PFAS) are extremely stable synthetic chemicals that have been employed for decades in various industries. The application of PFAS-containing f...
Strengthening process and outcomes of psychotherapies and leveraging academic-, policy-, and clinical partnerships to develop Routine Monitoring System in Kenya (SPARK)
ObjectiveThe efficacy of mental health interventions within sub-Saharan African settings remains underexplored. The proposed SPARK project seeks to illuminate the pathways for enha...
Deciphering metabolic crosstalk between adipocytes and endothelial cells to prevent obesity-associated diseases
Obesity remains the major risk factor for developing metabolic disease.Numerous studies have shown that maintaining adipose tissue functionality is enough to prevent metabolic dise...
The organization and function of specialized dopamine-striatal circuits.
Action selection, decision-making and cognitive flexibility are critical brain functions for humans and other animals in order to thrive and survive in a complex environment.The fr...
Assessing biochar stability in soils in the context of climate change using a novel approach: tree ring “bomb carbon” biochar
Biochar has attracted attention for its potential to improve soil fertility and sequester carbon (C). The biochar market is expanding, both in Sweden and globally.This project aims...
Who Wants to be a Working Retiree? Prerequisites and Working Conditions for People Combining Work and Retirement in the Temporary Staffing Sector
Research problem and specific questionsThis project explores the employment landscape of non-standard employment (NSE) tailored for working retirees in Sweden, focusing on the temp...
Broken barriers: the impact of mitochondrial introgression on the life-history and behaviour of threatened Atlantic salmon
The viability of wild populations is increasingly threatened by human-mediated gene flow between previously isolated groups.One crucial, but overlooked, consequence of human-mediat...
BioAIUnlock: Identification of stress-resistant anaerobic microorganisms to unleash the potential of lignocellulosic biomass in future biorefineries
In the rapidly changing international context, advancing Sweden towards a sustainable, fossil-free future is imperative.Anaerobic digestion (AD) of lignocellulosic biomass, key for...
Harm reduction and control: Policing people who use illegal drugs in a changing drug political landscape
Research questions: Policing of illegal drug use is a cornerstone in the abstinence-oriented Swedish drug policy.However, as harm reduction has become an increasingly important too...
Quantifying the impacts of extreme climatic events:Crop diversity, production performance, farmers’ adaptation
Europe, including Sweden, witnessed severe extreme climatic conditions between 2014 and 2018 that disrupted agricultural production and caused significant economic and environmenta...
Electroresponsive Lubrication: Tribotronic systems for greener machinery
Novel tribological systems can significantly contribute to global sustainability goals by reducing friction and wear.Due to large-scale high-power electrification, modern machinery...
Fraud, deceptive strategies, and vulnerability: A study on how we are exploited when we are most at risk
Research problem and specific questionsThis research project explores the strategies and approaches used to commit fraud against individuals in vulnerable positions.The project´s q...
Targeted stimulation of the β2-adrenoceptor for the treatment of type 2 diabetes
We have developed a unique platform for the discovery of novel compounds that can precisely modulate GPCRs to achieve discrete signaling outcomes. This has allowed us to synthesize...