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Why must I feel sick? The benefits of sickness behavior in the defense against pathogens
Everyone has experienced sickness behavior during an infection: feeling fatigued, having little appetite, wishing to stay alone, lacking motivation, and maybe even feeling depresse...
Synaptic connectome maladaptation in the circuits of innate fear
Mental disorders account for 30% of the global disease burden. Anxiety disorders represent the highest proportion with conditions such as post-traumatic stress disorder (PTSD). Wom...
Flavor and CP from beyond the electroweak scale
This project aims to develop extensions of the Standard Model of particle physics based on strongly coupled gauge theories, positing the Higgs boson as a composite particle.Buildin...
Harnessing genomic plasticity and functional potential to assess fitness of human gut bacteria strains
Our gut microbes have evolved alongside us, adapting to changes in diet, lifestyle, and environment over time.Consequently, they continuously generate new lineages, some of which e...
A CRISPR approach to develop pro-oxidant therapies for lung cancer
Lung cancer is one of the most common cancer forms with poor prognosis for patients with advanced disease.Evidence from our group and others suggest that lung cancer cells are dama...
PLOTTING THE DEVELOPMENT OF AUTOREACTIVE B CELLS IN AUTOIMMUNE DISEASE
Autoimmune diseases affect more than 5% of the world’s population. They are often debilitating and chronic, posing significant challenges to patients and Society. For many of these...
Geohash Barcoding: a novel single cell spatial toolbox to decipher malignancy through epigenetic regulation and genome instability crosstalk with the tumor microenvironment
Nonmutational epigenetic reprogramming and genome instability are two important hallmarks of cancer.To fully comprehend malignancy, it is essential to determine how these two hallm...
Unraveling tissue microenvironment dynamics in the pathogenesis of Group A Streptococcal necrotizing soft tissue infections
Necrotizing soft tissue infections (NSTI) are life-threatening infections mainly caused by Group A Streptococcus (GAS). GAS NSTI tend to affect younger, healthy individuals, often...
The Polymorphic Red Blood Cell Surface: For Safer Transfusions and a Role as Regulator of Hematopoiesis, Host-Pathogen Interactions and Hemostasis
Red blood cells (RBCs) constitute >80% of our cells and 118 million blood donations/year are used by healthcare globally. All need to be matched between donor and patient. T...
Deciphering the molecular mechanisms underlying human evolutionary adaptation to hypoxia
Multicellular organisms critically rely on systems such as red blood cell production (erythropoiesis) to sense oxygen availability and ensure a continuous systemic supply.Yet, the...
Chips JU WBG Pilot Line HE- National Part
Purpose and goal:The purpose of the project is to implement an integrated pilot line focused on the development of wide band gap (WBG) semiconductor technology for power and radio...
Chips JU WBG Pilot Line DIGITAL - National Part
Purpose and goal:The purpose of the project is to implement an integrated pilot line focused on the development of wide band gap (WBG) semiconductor technology for power and radio...
Towards the identification and individualized modulation of shared neurocognitive components of compulsivity
Compulsions - characteristic of obsessive-compulsive disorder, binge eating and addiction - are strong urges, that lead to behavioral patterns, often accompanied by anxiety or disc...
Optimized strategies for introducing new antibiotics in healthcare to preserve patient safety and counteract emergence of resistance
Following intense efforts to revive the dry antibiotic research and development pipeline, a few highly awaited antibiotics with activity against multidrug-resistant bacteria were r...
Group behaviour, information transfer and fitness consequences in mixed-species animal groups
The social environment provides an important ecological stage for selection to act.Our understanding of the mechanisms underlying group dynamics, and their fitness consequences for...
Autoimmune Regulation of GPCR Function
G protein-coupled receptors (GPCRs) play crucial roles in many biological functions in our body and they are the target of about 30% of all approved drugs.Despite advancements in t...
Schooling, life-courses and school experiences of students with neurodevelopmental disorders
Students with neurodevelopmental disorders (NDD) face increased risk of school failure, according to previous research.This project aims to generate comprehensive, longitudinal kno...
Proton-Coupled Electronic Processes
Proton-coupled electron transfer (PCET) has become recognized as a fundamental reaction of fundamental importance in broad areas of chemistry and biology and of practical importanc...
Drosophila olfaction across space and time
The sense of smell is crucial for most animals and serves as a significant model system in biological research, ranging from neuronal information processing to developmental biolog...
Glycan hopscotch: decoding how adenoviruses hop, skip, and jump their way into the cell
Many viruses, including several adenoviruses (AdV) are recruited at the cell surface through interactions with heparan sulfate (HS) in the glycan layer covering our cells (glycocal...