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606,025 grants found
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Evolutionary Arms Races Shaping the Germline Epigenome
Germline chromatin pathways are key to the stable inheritance of genetic and epigenetic information.They also participate in intense evolutionary battles between genetic entities w...
Neuronal implementation of cognitive maps for navigation
Intelligent behavior is based on internal models of the world that enable mental simulations and strategic planning.A leading model to study such “cognitive maps” are networks of p...
Optimising transient ischaemic attack (TIA) pathways to reduce ethnicity-based inequalities
AimTo reduce ethnicity-based inequities in access to and delivery of TIA pathways to improve stroke outcomes for people from ethnic minority groups. Research Questions (RQ) 1 Does...
Long-term antidepressant use and discontinuation in areas of high multiple deprivation
Background: The volume of antidepressant prescriptions has been increasing, with evidence that 30-50% of users may not need them. Antidepressants can be associated with adverse eff...
A randomised controlled feasibility study investigating surface neuromuscular STIMulation as an exercise therapy versus usual care in people with multiple sclerosis to help improve lower limb strength, walking and fatigue (STIM-MS)
Research question Is it feasible to conduct a randomised controlled trial with parallel economic evaluation of the effectiveness and cost effectiveness of surface neuromuscular ele...
RAtionalising Psychotropic medications for adults with Intellectual Disabilities: sCOPing (RAPID-COP).
Research questions Are there an adequate number of prescribers in the UK who see the need for a “StruCtured prOgramme of Psychotropic rationalisation in pEople with intel...
Desmopressin for reversal of Antiplatelet drugs in Stroke due to intracerebral Haemorrhage 2 (DASH-2)
Background Intracerebral haemorrhage causes 3.4 million deaths per year. Outcome is worse in patients with intracerebral haemorrhage who are taking antiplatelets.The number of peop...
Central roles of mycobacterial type VII secretion systems in intra- and inter-kingdom warfare
Bacteria interact with their environment via specialised secretion systems that deliver proteins outside of the cell. Due to a bias in research efforts, for many years such systems...
New Direct Empirical Evidence on Wage Setting
Our project proposes to provide new empirical evidence on wage setting.This evidence will enhance our understanding of industrial relations, and of wage inequality.First, we will o...
Antigen-specific treatments to target autoimmune kidney diseases
Chronic kidney disease (CKD) affects around 10% of the population worldwide and is associated with significant overall and cardiovascular mortality.CKD is a heterogeneous group of...
Optical Entanglement of Nuclear Spins in Silicon
A major breakthrough in quantum information processing is expected once “qubits”, carriers of quantum information, can be reliably integrated and controlled in silicon – the basis...
Design and Chemical Construction of Quasi-living Phagocytic Synthetic Cells for Artificial Phagocytosis of Bacteria
The growing occurrence of antimicrobial-resistant infections, compounded with the stalling development and approval of new antibiotic drugs, has created a therapeutic gap, threaten...
From RNA-peptide coevolution to cellular life at heated air bubbles
The origin of life on Earth is one of humanity's profound mysteries that lacks scientific answers.We aim to answer this fundamental question by performing pioneering experimen...
TURN-TAKING AND TURNING POINTS IN VIOLENT ENCOUNTERS. TOWARDS AN EXPLANATORY THEORY OF HOW CONFLICTS IN URBAN PUBLIC SPACE BEGIN, TRANSFORM AND END
Although violent police-civilian and civilian-civilian encounters constitute a tiny sliver of the social interactions that take place each day, their consequences can be far-reachi...
Alternative Modernities and Everyday Life in the Pre-emancipation Southern Caribbean (c. 1634–1863)
ISLANDLIVES will be the first interdisciplinary historical archaeological project to deploy a broad array of cutting-edge archaeological science techniques to study everyday life a...
Ecological and evolutionary role of specialized bacteria in algae health and carbon sequestration
Marine algae fixing CO2 into organic matter is central to the global carbon cycle.While the food chain and marine bacteria consume roughly half of the fixed carbon, a harder-to-deg...
Adaptive Separation using Dynamic Nanofibril Networks
This research program will develop materials, methods, and technologies that enable adaptive separation of molecules and particles using dynamic nanofibril networks.The ground-brea...
Privacy-Preserving Human MObility Trajectory Data GeneratOr
People travel and leave their location history as mobility trajectory data.This data is invaluable for a wide range of location-based services, including city planning, traffic con...
eddy Retention of Eggs and LArvae in the Catalan Shelf
In the Northwestern Mediterranean Sea (NWMED), anticyclonic eddies (clockwise spinning flows) increase fishes eggs and larvae (ichthyoplankton, IP) survival rate by providing prote...
Application of novel cost-effective imaging tools for the MONItoring of benthic ecosystems in the offshore marine area of CAp de Creus
The offshore marine area of Cap de Creus (NW Mediterranean), characterised by its complex geological setting and rich epibenthic ecosystem, was declared a Site of Community Importa...