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199,248 grants found
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Uncovering the molecular mechanisms of DNMT1-mediated inheritance of gene silencing
Every cell in the body harbors essentially identical DNA sequences, so how are different cell types established and maintained? Different cells express a distinct subset of DNA seq...
Doctors on the Streets: Health, Citizenship and Political Mobilisation of Medical Professionals in Pakistan
My career vision is to lead the field of anthropological research on health policy and systems in Pakistan, in order to drive new directions in this field, and promote scholarly ca...
Capturing fusion glycoproteins in motion: a focus on Ebola virus
The Ebola virus (EBOV) fusion glycoprotein GP mediates cell entry and is the main virus antigenic target.The molecular mechanisms underlying entry and antibody-mediated neutralizat...
Between deception and dissent: regulating unproven, disproven, or misleading health-related claims
This Discovery Award will explore how unproven, disproven, or misleading health-related claims are regulated in contemporary states; examine the socio- political implications of cu...
Predicting long-term outcomes in people with psoriasis who achieve disease control on systemic therapy: a mixed methods study
Background Psoriasis is a common, incurable inflammatory skin disease associated with high psychosocial morbidity and economic impact.Systemic therapy is often required for individ...
Supracellular coordination in tissue morphogenesis
How organ shape is genetically encoded remains a major unresolved question in biology. All tissues arise from simple primordia that become patterned through transcriptional changes...
Work-related suicide. An international social justice analysis
This project will undertake a first cross-national, multidisciplinary and qualitative study of work-related suicide in the UK, France and Canada, aiming to generate new knowledge a...
How do CNS border-derived B-cells shape brain immunity and behaviour during chronic infections?
Circadian rhythms and sleep are extremely important processes impacting both our physical and mental health.However, when we experience chronic infections, such as Human African tr...
Transforming child health outcomes through data linkage
Survival rates following early life critical illness have improved markedly. However, there is a resulting impact on physical and mental health conditions for survivors.To date, th...
Impact of metabolic cross-feeding interactions in mixed-species chronic wound biofilms on tolerance and evolution of antimicrobial resistance
Studies on the microbial ecology of infected wounds have revealed a diverse array of bacterial species, including antimicrobial-resistant microorganisms, that can play detrimental...
Advancing our Understanding of Intersectionality in Work and Health Research: Training, International Collaboration, and Proposal Development.
The Wellcome Accelerator Award will allow me to develop as an early-career researcher in work and health research by disseminating my thesis, completing training to build my skill...
Understanding and exploiting ribosome biogenesis dysregulation in cancer
Background: Ribosome biogenesis is a highly complex and metabolically demanding process that is essential for protein synthesis in all cells. In normal cells, ribosome biogenesis i...
CRUK Edinburgh-UCL Brain Tumour Centre Of Excellence 2024
Established in 2018, the CRUK Edinburgh-UCL Brain Tumour Centre of Excellence (CoE) is beginning to change the UK brain tumour research landscape by building a critical mass of res...
Enabling Environmentally Sustainable Computational Science through foundational initiatives and the Green Algorithms tools
Computing is an essential component of modern scientific research and it comes with significant, but not well-understood, environmental impacts.Besides, there is a lack of open acc...
Birthing at Burning Places: An ethnographic exploration of intersections among climate-linked risks, maternal nutritional health, and cultural practices in Sindh Pakistan
Extreme weather and natural disasters contribute to a wide range of health, food, and nutritional risks, particularly in low—and middle-income countries such as Pakistan. Women are...
The sound of Cancer: towards characterisation of elasticity
Tumours, dysplastic tissue, and single cancerous cells exhibit different stiffness (elasticity) compared to their healthy counterparts. These changes arise at the cellular level to...
Detection and characterisation of p53 aggregates in liquid biopsy with ultrasensitive immunoassays
Background p53 is a pivotal tumour-suppressor that regulates various critical cellular processes. However, p53 can form amyloid aggregates that lose tumour-suppressing functions an...
Advanced Ultrasound Imaging for Early Cancer Detection and Diagnosis
Background: Early detection and clinical intervention of cancer can significantly increase chances of patient survival. Imaging of the microvasculature provides opportunities for e...
Nascent DNA Strand Maturation in Human Cells and its Targeting by Inhibitors of Poly(ADP-Ribose) Metabolism
Background: Inhibitors of the DNA strand break sensor protein poly(ADP-ribose) polymerase-1 (PARP1) are now employed in the clinic, to treat cancers with hereditary mutations in BR...
Cellular and molecular pathways in blood flow-provoked atherosclerosis in women and men
sex differences