Results for Technology
53,864 grants found
Showing 49,201 – 49,220 of 53,864 grants for "Technology"
Leveraging Tumor Suppressor Inactivation for Osteosarcoma Therapy
PROJECT SUMMARY Osteosarcoma (OS) is the most common malignant bone tumor, found in the pediatric population and often leads to death due to tumor progression and metastasis. Despi...
cryoEDU: An online curriculum and software platform for hands-on learning in single-particle cryoEM and cryoET
cryoEDU: An online curriculum and software platform for hands-on learning in single- particle cryoEM and cryoET SUMMARY Single-particle cryogenic electron microscopy (cryoEM) has b...
Flow Acceleration for Stroke Thrombolysis (FAST) System
Acute ischemic stroke (AIS) results from a blood clot in the neurovasculature and is the 5th leading cause of death and 1st leading cause of neurological disability in the United S...
Ultra-High Efficiency Microwave Plasma for Extreme Low-Power Applications
Cold plasma is a critical technology in many application fields such as plasma medicine, food preservation, water treatment, reconfigurable electronics, high-quality lighting, elec...
Function of asthma- and allergic disease-associated risk variants and genes in lung immune cells
Asthma and allergic diseases (AADs) affect over 25 million children and adults in the United States, and AAD incidence has been increasing over the last 4 decades. There is signifi...
Activating Peripheral Glia to Relieve Visceral Pain in Animal Models of Urological Chronic Pelvic Pain Syndrome (UCPPS)
PROJECT SUMMARY/ABSTRACT There are significant gaps in our knowledge of how peripheral GFAP+ glia regulate sensory neuronal activity and their involvement in primary afferent sensi...
Activating Peripheral Glia to Relieve Visceral Pain in Animal Models of Urological Chronic Pelvic Pain Syndrome (UCPPS)
PROJECT SUMMARY/ABSTRACT There are significant gaps in our knowledge of how peripheral GFAP+ glia regulate sensory neuronal activity and their involvement in primary afferent sensi...
Function of asthma- and allergic disease-associated risk variants and genes in lung immunecells
Asthma and allergic diseases (AADs) affect over 25 million children and adults in the United States, and AAD incidence has been increasing over the last 4 decades. There is signifi...
Activating Peripheral Glia to Relieve Visceral Pain in Animal Models of Urological Chronic Pelvic Pain Syndrome (UCPPS)
PROJECT SUMMARY/ABSTRACT There are significant gaps in our knowledge of how peripheral GFAP+ glia regulate sensory neuronal activity and their involvement in primary afferent sensi...
Quantitative characterization of neuronal trans-SNARE complexes using DNA origami
Project Summary/Abstract A key step in neurotransmission is the fusion of the synaptic vesicle (SV) membrane with neuronal plasma membrane (PM), to release neurotransmitters into t...
The Next-Generation Developmental and Reproductive Toxicology (DART) Assay using High-Content Analysis of Genetically Diverse C. elegans Populations
Abstract: Developmental and reproductive toxicology (DART) studies are commonly conducted using a large number of genetically inbred rodent and rabbit strains to predict adverse ef...
Flow Acceleration for Stroke Thrombolysis (FAST) System
Acute ischemic stroke (AIS) results from a blood clot in the neurovasculature and is the 5th leading cause of death and 1st leading cause of neurological disability in the United S...
Development, Piloting and Dissemination of an Integrated Clinical and Social Multi-level Decision Support Platform to Address Social Determinants of Health Among Minority Populations in Baltimore City
PROJECT SUMMARY Achieving a comprehensive assessment of a person's health and addressing health disparities goes beyond just documenting clinical diseases and medical interv...
Spatiotemporal tools to interrogate O-GlcNAc functions in cellular signaling
Abstract The overall goal of the Fehl laboratory is to develop chemical biology strategies to determine the functional impact of protein modifications during signaling processes. S...
Pre-existing Maternal Humoral Immunity as a Barrier to CRISPR-Cas9 In Utero Gene Editing for Inherited Metabolic Liver Diseases
In utero CRISPR-Cas9 gene editing (IUGE) has several potential advantages over postnatal gene editing.It increases editing efficiency by taking advantage of fetal properties – smal...
Assessing the feasibility and acceptability of using non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) to reduce PTSD symptoms in WTC responders
ABSTRACT Posttraumatic Stress Disorder (PTSD) remains the most prevalent mental health (MH) diagnosis for first responders involved with responding to the 9/11 World Trade Center (...
A novel mouse model of TDP-43 Proteinopathy in FTLD-ALS: Elucidating the role of TDP-43 acetylation in neurodegeneration and proteostasis impairment
Project Summary Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are two progressive neurodegenerative disorders on a spectrum of disease related to...
Spatiotemporal tools to interrogate O-GlcNAc functions in cellular signaling
Abstract The overall goal of the Fehl laboratory is to develop chemical biology strategies to determine the functional impact of protein modifications during signaling processes. S...
Hyperspectral Single Photon Imaging of Targeted Alpha-Emitters
Targeted alpha-emitter therapy (TAT) is an emerging modality in the cancer therapy. By directly killing cancer cells it is less susceptible to development of resistance. Combinatio...
Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants
Project Summary/Abstract There is growing societal and scientific interest in using genomic sequencing (GS) as screening to identify genetic predispositions for disease early in li...