Results for Environment
40,772 grants found
Showing 37,401 – 37,420 of 40,772 grants for "Environment"
Early-life Risk Factors for Inflammatory Bowel Disease
This project will evaluate early-life risk factors associated with inflammatory bowel diseases (IBD), biomarker of intestinal inflammation and loss of gut microbiome diversity. Can...
Small-molecule Inhibition of Glycogen Synthase Kinase-3 Sensitizes Colorectal Cancer Cells and Stimulates Immune Cells to Bolster Immune Cell-mediated Tumor Cytotoxicity
PROJECT SUMMARY Globally, colorectal cancer (CRC) ranks third in incidence and second in mortality. Immune checkpoint blockade (ICB) has demonstrated impressive efficacy in microsa...
Advancing Recovery Pathways and Support Services for Alcohol Use Disorders among Black Men and Women
Black Americans demonstrably suffer from a range of health disparities rising from a long history of structural inequities and racism. Although Black Americans are slightly less li...
Small-molecule Inhibition of Glycogen Synthase Kinase-3 Sensitizes Colorectal Cancer Cells and Stimulates Immune Cells to Bolster Immune Cell-mediated Tumor Cytotoxicity
PROJECT SUMMARY Globally, colorectal cancer (CRC) ranks third in incidence and second in mortality. Immune checkpoint blockade (ICB) has demonstrated impressive efficacy in microsa...
Advancing Recovery Pathways and Support Services for Alcohol Use Disorders among Black Men and Women
Black Americans demonstrably suffer from a range of health disparities rising from a long history of structural inequities and racism. Although Black Americans are slightly less li...
Doctoral Dissertation Research Award: use of Eggshell Isotopes for Mobility
This doctoral dissertation research will investigate human mobility by analyzing how a traditional group managed resource procurement in a marginal environment using isotopic analy...
CAREER: Convective Aggregation and the Hydrological Cycle, Cloud Feedbacks, and Climate Sensitivity
Tropical thunderstorm clouds often clump together into clusters, which affects humidity, rainfall, and cloudiness. This clumping can occur because of patterns of warm and cool ocea...
Collaborative Research: CDS&E: Computational Investigation of Solvent Effects on Enzyme Catalysis
Enzymes are specialized proteins that catalyze chemical reactions in biological systems. Changes in temperature, pressure, or composition of the environment surrounding the protein...
SRS-RN: Hybrid Water Infrastructure and Regional Sustainability - Planning a Convergence Science Approach in Greater New Orleans
Traditional water infrastructure systems like drainage pumps, flood walls, and levees are increasingly incorporating nature based, or green infrastructure, features. Many water gov...
Trauma and Shock-Induced Microvascular Dysregulation and Coagulopathy
Program Director/Principal Investigator (Last, First, Middle): Kozar RA/ Dong JF Project Summary Trauma is the leading cause of preventable death, with the majority of deaths cause...
Uncovering the therapeutic potential of adipose tissue derived neural stem cells for Hirschsprung's disease.
PROJECT SUMMARY The overarching objective of our research is to develop a stem cell therapy from subcutaneous fat tissue (SAT) to replace the congenitally absent enteric nervous sy...
The interaction effects of genetic variants, age, diet, sex and mitochondrial copy number on Alzheimer's disease, aging-phenotypes and longevity
As the average age of the population increases, understanding the biology of longevity and diseases of aging is increasingly important. The key role of mitochondria in Alzheimer’s...
2022 Photosensory Receptors and Signal Transduction GRC/GRS
Summary At the 2022 Photosensory Receptors and Signal Transduction (PRST) Gordon Research Conference (GRC) to be held in Ventura CA, scientists from all over the world gather to pr...
Defining the induction and maintenance of myelin-specific tolerance in T cells and B cells using local lymph node depots
PROJECT SUMMARY: During autoimmunity, the body incorrectly identifies “self” molecules as foreign. In multiple sclerosis (MS) attack of myelin in the central nervous system (CNS) l...
Neural circuitry underlying emotional abuse and depression in sexual minority youth
PROJECT SUMMARY/ABSTRACT. Emotional abuse (EA) during childhood and adolescence is associated with greater risk and severity of depression. EA is particularly common among sexual m...
Influence of Genetic Background on Bone Anabolic Response to Mechanical Loading
SUMMARY Osteoporosis is a heritable disease of low bone mass and increased fracture risk. Drugs are available to treat low bone mass, yet they carry risks and have limited indicati...
Optical probe and instrumentation development for in vivo near-infrared fluorescence imaging of Alzheimer's disease
PROJECT SUMMARY / ABSTRACT The main neuropathological hallmarks of Alzheimer's disease (AD) are the extracellular accumulation of amyloid plaque deposits and intracellular for...
Implementation Strategies to Promote Advance Care Planning among Persons Living with ADRD and those with Mild Cognitive Impairment in Outpatient Primary Care Practices
Many community-dwelling persons living with Alzheimer’s disease and related dementias (AD/ADRD) and those with mild cognitive impairment (MCI) receive aggressive medical interventi...
Diet and metabolic factors in the pathogenesis of microscopic colitis
PROJECT SUMMARY/ABSTRACT Microscopic colitis (MC) is a debilitating T-cell-mediated inflammatory disease of the large intestine with an incidence that now rivals that of inflammato...
The interaction effects of genetic variants, age, diet, sex and mitochondrial copy number on Alzheimer's disease, aging-phenotypes and longevity
As the average age of the population increases, understanding the biology of longevity and diseases of aging is increasingly important. The key role of mitochondria in Alzheimer’s...