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606,025 grants found
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STrengthening Research OpportuNities for Growth at Meharry Medical College (Meharry-STRONG)
Project Summary/ Abstract The goal of the STrengthening Research OpportuNities for Growth at Meharry Medical College (Meharry- STRONG) Program is to assess research capacity and de...
Mentoring Translational Cancer Research in Oklahoma
Abstract Oklahoma faces a significant burden of cancer, with a high incidence and mortality rate. The impact of cancer is particularly profound among diverse communities, including...
Admin Core
Abstract Cancer is a pressing public health challenge in the United States, demanding innovative solutions and effective therapies. Research is pivotal in addressing this challenge...
Cell and Tissue Analysis Core
Abstract The Cell and Tissue Analysis (CTA) Core, a pivotal component of COBRE Phase 3, pioneers molecular, cellular, and tissue analysis technologies, advancing our understanding...
Cell and Molecular Imaging Core
Abstract The Cell and Molecular Imaging (CMI) Core of COBRE Phase 3 strives to maintain its leadership in molecular, cellular, and animal imaging technologies, furthering our under...
Linking Exercise for Advancing Daily Stress (LEADS) Management and Resilience in Black Families
Project Summary/Abstract Chronic stressors, such as racial discrimination, have wide-reaching harmful effects on the physical, social, and psychological well-being of many African...
Investigating the role of Lipocalin Prostaglandin D2 Synthase and its metabolite PGD2 in non-alcoholic fatty liver disease
PROJECT SUMMARY/ABSTRACT Despite non-alcoholic fatty liver disease (NAFLD) being the most common chronic liver disease worldwide, molecular mechanisms contributing to its etiology...
Development of novel approaches for gene editing therapies of cystic fibrosis
SUMMARY Chronic lung infection is the primary cause of death in patients with cystic fibrosis (CF). CF is caused by mutations in the cystic fibrosis transmembrane conductance regul...
Tau Mediates Microtubule and Mitochondrial Dynamics to Control Cellular Organization and Alveolar Epithelial Repair
SUMMARY Alveolar tissues must maintain proper cellular organization to perform vital functions such as gas- exchange at homeostasis and during repair. In human lungs, type-1 alveol...
Rapid Diagnosis and Treatment Response Phenotyping of Immune Checkpoint Inhibitor-Associated Acute Interstitial Nephritis
PROJECT SUMMARY Immune checkpoint inhibitor (ICI) therapy has revolutionized cancer care; however, ICIs can lead to off-target immune-related adverse events (irAEs) such as ICI-ind...
Understanding the Role of EIF4A2 in Neurodevelopment
PROJECT SUMMARY/ ABSTRACT Neurodevelopmental disorders (NDD) are common, affecting 3% of the global population with emerging data suggesting that many are attributable to a genetic...
Bridging the Treatment Gap by Expanding Access to Care for People with Epilepsy in Kenya (BEACON)
PROJECT SUMMARY/ ABSTRACT Epilepsy is responsible for about 1% of the global burden of disease, with the highest disease-related burden found in sub-Saharan Africa. The majority of...
Rift Valley fever virus NSs protein interacts with LC3 family members to inhibit antiviral autophagy
PROJECT SUMMARY/ABSTRACT Rift Valley fever virus (RVFV) is a viral zoonosis that causes severe disease in ruminants and humans [1]. Concerns are heightened regarding the introducti...
Radiation Guided Ablation for Ventricular Tachycardia
Ventricular tachycardia can be a life-threatening arrhythmia that requires effective and timely treatment. This treatment often takes the form of catheter based ablation; however,...
Development of a WT RNAP-based kit for high-yield synthesis of chemically modified RNA
ABSTRACT With the growing number of RNA therapeutics approved for clinical uses and the fundamental advantages of using RNA in regulating protein expression, vaccines, genome editi...
Development of a Comprehensive Hen's Egg Model for Genotoxicity Testing
Project Summary Pharmaceuticals and various industrial chemicals undergo comprehensive toxicological assessment in order to safeguard human health. Genetic toxicology is a key comp...
Validation of quantative method for thiamine detection in animal feed, tissue and plasma
1 Project Summary 2 The Thiamine HPLC-FLD quantification project is proposed by the WADDL-ASL laboratories to 3 fill the analytical gap in the Vet-LIRN network by developing a stan...
The role of phosphorylation in the cellular organization of the proteome
PROJECT SUMMARY Protein phosphorylation is the most important and most extensively studied mechanism by which cells rapidly sense signals, transduce signals, and execute decisions....
Molecular mechanism of eukaryotic chromosome replication
Summary DNA replication stress is a major source for genome instability associated with numerous diseases, including cancer. Therefore, understanding the molecular basis of replica...
Analytical characterization and validation of blood-biomarkers for monitoring TBI evolution
Abstract Consistent with the overall mission of NINDS for the PAR-21-056 Announcement, Analytical Validation of a Candidate Biomarker for Neurological Disease, we have assembled a...