Results for Environment
40,772 grants found
Showing 35,421 – 35,440 of 40,772 grants for "Environment"
Host and Viral Determinants of Orthobunyavirus Vertical Transmission: Novel Model Systems to Understand the Mechanisms of Congenital Disease in Humans and Ruminants
PROJECT SUMMARY/ABSTRACT Emerging infectious diseases pose a significant threat to human and agricultural health; therefore, it is imperative that we take a proactive approach towa...
Identifying novel regenerative treatments for CNS injury in adult mammals
Abstract We propose to study whether targeting both the transcription factor ZNF362 and cytoskeletal non-muscle myosin IIA and IIB (NMIIA&B) will promote better axon regenerati...
Role of type 1 IFN in eye infection
ABSTRACT HSV-1 infection is a leading cause of eye disease and genital herpes but no HSV-1 vaccines have shown efficacy in humans. It elicits only a partially protective immune res...
Bridges to the Baccalaureate at Cal State LA
Abstract/Summary California State University Los Angeles (Cal State LA), East Los Angeles College (ELAC), and Pasadena City College (PCC) propose to deepen their collaboration to e...
Identifying novel regenerative treatments for CNS injury in adult mammals
Abstract We propose to study whether targeting both the transcription factor ZNF362 and cytoskeletal non-muscle myosin IIA and IIB (NMIIA&B) will promote better axon regenerati...
Structural Mechanisms of DNA Damage Sensing and Activation of the ATR, Fanconi Anemia, and ATM Checkpoints
Genetic instability is a hallmark of cancer. The cell has evolved an intricate set of pathways that sense and repair DNA damage, which is an inevitable consequence of cellular meta...
Bridging the gap: joint modeling of single-cell 1D and 3D genomics
PROJECT SUMMARY/ABSTRACT Advances in single-cell technologies have enabled three-dimensional (3D) genome structure profiling and simultaneous capture of the transcriptome and epige...
Structural Mechanisms of DNA Damage Sensing and Activation of the ATR, Fanconi Anemia, and ATM Checkpoints
Genetic instability is a hallmark of cancer. The cell has evolved an intricate set of pathways that sense and repair DNA damage, which is an inevitable consequence of cellular meta...
Oxidative Stress and Mitochondrial Dysfunction in Chemogenetic Heart Failure
This K08 Mentored Clinical Scientist Career Development Award describes a five-year research and training program of the principal investigator (PI), Dr. Fotios Spyropoulos, that w...
Development of a predictive model and electronic health record-based probability scoring system and dashboard for postoperative respiratory failure
PROJECT SUMMARY/ABSTRACT The objective of this research proposal project is to identify modifiable factors associated with different postoperative respiratory failure (PRF) phenoty...
Prospective predictors of risk and resilience trajectories of mental health in US youth during COVID-19
The COVID-19 pandemic has had substantial effects on youth in multiple aspects of life, raising concern about its impact on youth mental health. Indeed, mounting data suggest that...
Bridges to the Baccalaureate at Cal State LA
Abstract/Summary California State University Los Angeles (Cal State LA), East Los Angeles College (ELAC), and Pasadena City College (PCC) propose to deepen their collaboration to e...
Dual Language Development in Young Children with ASD
Project Summary/Abstract For the millions of bilingual parents around the world, and in the US specifically, one of the most pressing questions in the face of the Autism Spectrum D...
Movement Amplification Training to Enhance Walking Balance Post-Stroke
Project Summary People with chronic stroke (PwCS) have substantial walking balance dysfunctions that limit independence and participation in walking activities. There is a pressing...
Biophysical Model of Enzyme Catalysis: Conformational sub-states, solvent coupling and energy networks
ABSTRACT Enzymes have important implications for understanding many human diseases as well as for developing new medicines and therapies. Design of small molecule drugs without sid...
NSF-BSF: Mechanism of Cuticle Remodeling by Hypoxia
The skin is a line of defense between an animal’s interior and the external world, and the structure and function of the skin affects organismal survival. This research investigate...
PM: Enhancing BSM Searches with Cold Atom Sources
While the Standard Model of particle physics has been remarkably successful, there are many lines of evidence, both from particle colliders and from astrophysical measurements, tha...
The Medical District UTSW-D FIRST Program
OVERALL: ABSTRACT This Dallas Medical District UTSW-D FIRST proposal is submitted jointly by the University of Texas Southwest- ern Medical Center (UTSW) and the University of Texa...
Collaborative Research: Multiscale Cardiomyocyte Mechano-Adaptation
During every heartbeat, the cells stretch and move as the heart contracts and fills. In disease or following surgery, the way the heart deforms can change, which causes the cells t...
Collaborative Research: Expanding the diversity of iron oxidation mechanisms via genetics, microscopy and 'omics in Leptothrix
Iron is practically ubiquitous across Earth, making it an important component in the chemistry of life and in the chemistry of soils, sediments, and groundwater. Iron in contact wi...