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606,025 grants found
Showing 33,941 – 33,960 of 606,025 grants
Development of novel genetic tools for the study of type IV collagens
PROJECT SUMMARY The broad goal of our research is to understand the biological functions of type IV collagens in the extracellular matrix and determine the mechanisms by which they...
Northwest Regional Research Center
The Northwest Portland Area Indian Health Board (NPAIHB) is proposing a partnership of Northwest tribes and tribal organizations to develop a Northwest Regional Research Center (NW...
A multidimensional investigation of social support for transgender and nonbinary people and its impacts on health and well-being: Measurement development using community engagement
PROJECT SUMMARY/ABSTRACT Trans and nonbinary (TNB) individuals experience mental and physical health disparities compared to cisgender peers, such as higher rates of depression and...
Building a Collaborative Research and Training Platform for HIV and Rheumatic and Musculoskeletal Diseases in Uganda
PROJECT SUMMARY/ABSTRACT Sub-Saharan Africa bears the greatest burden of the global human immunodeficiency virus (HIV) epidemic. Uganda is no exception, with over 1.5 million perso...
The mechanisms of MEIG1 complex in mammalian spermiogenesis and fertilization
Natural fertilization and embryo development require heathy spermatozoa to carry male genetic material to fertilize the egg. During the final phase of spermatogenesis, the spermati...
High-performance BPA-free dental restoration composites with remineralization capabilities
ABSTRACT The global market size for restorative dentistry is estimated to be around $20.2 billion in 2023 and expected to grow to $36.2 billion by 2030. In the US, $2.8 billion is...
Advanced Research Training in SDOH (ART)
PROJECT SUMMARY Interdisciplinary researchers at Emory University propose to plan and execute a program on Advanced Research Training in SDOH (ART). The primary goals are to increa...
Early interventions at ART initiation to reduce the HIV-1 reservoir and enhance adaptive immune responses
Increasing efforts are being made to understand whether early intervention after HIV-1 infection can enable long- term viral control and reduction of the viral reservoir through th...
Immunoregulatory biomaterials for modulating arthritis flares
PROJECT SUMMARY Uncontrolled disease fluctuations in a subset of joints, referred to as flares, can be a common experience in autoimmune arthropathies even in the context of overal...
How Distinct Age-Associated B Cell Subsets Can Protect the Aged from Influenza
ABSTRACT: How Distinct Age-Associated B Cell Subsets Can Protect the Aged from Influenza. With age, the generation of T follicular helpers from naive CD4 T cells, and of germinal c...
Antibody Biomarkers of Cryptococcosis in Immunosuppressed Solid Organ Transplant Recipients
Project Abstract Dr. Hyun Ah Yoon proposes a mentored clinical and translational research project and career development plan to identify antibody (Ab) biomarkers of risk for crypt...
KIBRA-induced biomechanical changes and therapeutic targeting in podocytes
Despite recent progress in the identification of mediators of podocyte injury, mechanisms underlying podocyte loss remain poorly understood, and cell-specific therapy is lacking. O...
Molecular Modeling of the DR domain of an HIV restriction factor PSGL-1
Project Summary/Abstract Studying the anti-HIV mechanisms of restriction factors is central to understanding virus-host interaction and for developing novel therapeutics. Recently,...
Preclinical Testing of Potential Next-generation Antischistosomal Compounds
PROJECT SUMMARY / ABSTRACT Human schistosomiasis is a disease caused by species of the genus Schistosoma, which globally affects over 200 million people. The major species affectin...
Acute and chronic effects of GLP-1R agonism on NPY/AgRP neuronal activity
Glucagon-like peptide 1 (GLP-1)-based therapeutics have profound effects on body weight and blood glucose management. GLP-1 cells are located in both the periphery and the caudal m...
Talazoparib with enzalutamide for untreated hormone-relapsed metastatic prostate cancer [ID4004]
Prostate cancer is a condition in which tumours develop in the prostate a gland in the male reproductive system.The exact cause is unknown but environmental and genetic factors are...
A numerical integrated model for the power output of floating offshore wind farms that are fully grid-connected during sea storms
The implementation of the energy policy to clean our energy system will lead to massive offshore wind power installations in the coming decades, thus causing the electricity grid b...
WARBIO: Armed conflicts effect on global biodiversity
Armed conflicts have increased by 97% over the last years and over 80% of these conflicts have occurred in biodiversity hotspots, with several impacts on the environment. Most impa...
Report of Intent from the food system
Purpose and goal:By compiling and presenting a report on intentions that showcases the commitments and engagements from various stakeholders within the food system towards our miss...
Treatment outcome requirements for disease prevention in Chagas disease
Abstract Infection with the protozoan parasite Trypanosoma cruzi is generally controlled but often not eliminated by host immune responses. In humans and many other hosts, this per...