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632b with DSCA
632b with DSCA
President's Emergency Plan for AIDS Relief - PEPFAR Operational Plan Programs
The DoD HIV/AIDS Prevention Program (DHAPP) mission is to reduce the incidence of HIV/AIDS among partner militaries across the globe by assisting in developing and implementing cul...
A Rapid Phenotypic Drug Susceptibility Testing System for Tuberculosis
Abstract Tuberculosis (TB) is second only to COVID-19 as the most lethal cause of death from a single infectious agent. In 2020, an estimated 10 million people developed TB, nearly...
Optimal Window of Opportunity for Granulosa Cell Gene Therapy in Galactosemia
PROJECT SUMMARY / ABSTRACT Hereditary deficiency of galactose-1-phosphate uridylyltransferase (GALT, E.C. 2.7.7.12) activity in humans can lead to a potentially lethal disease call...
Child Abuse and Risk of Gynecologic Disease in a North American Cohort
ABSTRACT Uterine leiomyomata (UL), endometriosis, and polycystic ovarian syndrome (PCOS) are debilitating gynecologic conditions diagnosed in up to 30% of North American women. The...
LRRK2 and oxidative stress in Parkinson’s disease
Mutations in LRRK2 are the most common cause of autosomal dominant Parkinson's disease (PD) and it appears that all such pathogenic mutations are associated with aberrantly en...
Living Beyond Cancer: How Distance Impacts Childhood Cancer Survivorship Care
PROJECT SUMMARY/ABSTRACT Significance: Over 15,000 children aged
EMERGE: Early Markers of Expressive and Receptive (language) Growth in Ethnically diverse autistic toddlers
PROJECT ABSTRACT The majority of 18-24-month-old autistic children have no words, demonstrating significant delays in their language development, a leading source of concern that o...
SARS-CoV-2 immune responses in patients with lymphoma
Project Summary Non-Hodgkin lymphoma and chronic lymphocytic leukemia (NHL/CLL) patients have immune system deficits that arise from the cancer and are aggravated by lymphoma thera...
Massively Parallel Biochemical Annotation of Missense DNA Variants to Support Newborn Screening by Whole Genome Sequencing
Project Summary Newborn screening (NBS) provides early diagnosis of treatable disorders. Most NBS is based on measurement of biomarkers in dried blood spots (DBS). However, there a...
Targeting muscle kynurenine aminotransferases and the AHR pathway to mitigate age-related physical decline
ABSTRACT. The aging process involves a gradual deterioration of physical and physiological functions, ultimately leading to mortality. Frailty and muscle weakness are prevalent con...
Impact of preadolescent psychostimulants on neurophysiology and sleep/wake disturbances
PROJECT SUMMARY Children with attention-deficit/hyperactivity disorder (ADHD), whether taking stimulant medications or not, experience more sleep problems than their peers. These n...
Metagenomic surveillance of pathogen and antimicrobial resistance gene transmission in hospitalized neonates
PROJECT SUMMARY Healthcare-associated infections (HAIs) are a major challenge in neonatal intensive care units (NICUs), resulting in prolonged hospital stays, and preventable morbi...
Understanding disparities in cardiovascular toxicity among breast cancer survivors in Arkansas
PROJECT SUMMARY Cardiovascular disease (CVD) is a rapidly growing public health concern for female breast cancer (BC) survivors. This is due, in part, to cardiovascular (CV) toxici...