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Showing 33,42133,440 of 606,025 grants

Active NON-SBIR/STTR RPGS
Novel coenzyme Q6 variant reveals non-immune determinants of survival during pneumococcal sepsis
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Washington University United States 2024 – 2028

1 PROJECT SUMMARY 2 Sepsis caused by Streptococcus pneumoniae (Sp; the pneumococcus) causes significant morbidity and 3 mortality, despite vaccines, antimicrobials, and supportive...

$7.39M
USD
Active NON-SBIR/STTR RPGS
Breast Cancer Diagnostic Kit to Improve Early Diagnosis in Uganda
NATIONAL CANCER INSTITUTE Vanderbilt University Medical Center United States 2024 – 2029

ABSTRACT: Breast cancer in Uganda presents a pressing public health challenge, characterized by late-stage diagnoses and high mortality rates, particularly among women residing in...

$7.28M
USD
Active NON-SBIR/STTR RPGS
Mettl14 mediated mRNA methylation orchestrates postnatal cardiac development
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE University of Pittsburgh At Pittsburgh United States 2024 – 2026

The adult mammalian heart has limited capacity for regeneration following injury, but the neonatal mouse heart possesses remarkable regeneration capacity within 7 days after birth....

$1.19M
USD
Active TRAINING, INSTITUTIONAL
ALIADOS: Advanced training in Latino multi-level Intervention reseArch for DOctoral Scholars
NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH D... San Diego State University United States 2024 – 2029

PROJECT SUMMARY Latine populations in the U.S. continue to be disproportionately impacted by health disparities, including those related to chronic and infectious diseases. These d...

$2.4M
USD
Completed OTHERS
Commitment to Recovery: Alaska Native Community Needs for Substance Use Treatment
NATIONAL INSTITUTE ON DRUG ABUSE Southcentral Foundation United States 2024 – 2025

AbstractSouthcentral Foundation (SCF) is a successful Tribally-owned and -operated healthcare organization in southcentral Alaska, a region spanning 104,713 square miles, 55 rural...

$2.53M
USD
Active NON-SBIR/STTR RPGS
Targeted suppression of ALDH1A3 for endothelial beneficial management of restenosis after vascular surgery
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE University of Virginia United States 2024 – 2028

Project Summary Angioplasty is commonly performed to press open occluded coronary and peripheral arteries. Unfortunately, this invasive procedure often induces smooth muscle cell d...

$7.2M
USD
Active NON-SBIR/STTR RPGS
Uncovering and understanding the many functions of ICAM-1 in the lungs during homeostasis and innate immune responses
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE University of North Carolina Chapel Hill United States 2024 – 2028

Abstract The gene Icam1 codes for intercellular adhesion molecule-1 (ICAM-1, CD54), a member of the Ig-like superfamily of adhesion proteins and a type 1 membrane-bound glycoprotei...

$7.59M
USD
Active NON-SBIR/STTR RPGS
INTEGRATIVE GENOMICS OF CHILDHOOD INTERSTITIAL LUNG DISEASE
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Boston Children'S Hospital United States 2024 – 2028

Children’s Interstitial and Diffuse Lung Diseases (chILD) are disorders of the lung tissue that present in infancy and early childhood. ChILD pose major burdens on thousands of chi...

$8.44M
USD
Active NON-SBIR/STTR RPGS
Hormonal Drivers of Perimenopausal Inflammation and Mood Symptoms
NATIONAL INSTITUTE OF MENTAL HEALTH Icahn School of Medicine At Mount Sinai United States 2024 – 2029

Up to one third of women, up to a billion people, experience the emergence or worsening of depressive and anxiety (mood) symptoms as their hormonal milieu shifts into perimenopause...

$9.1M
USD
Active OTHER RESEARCH-RELATED
A Longitudinal Mixed Methods Study of Psychosocial and Behavioral Health After Non-Fatal Firearm Injuries Among High-Risk Youth
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD... University of Texas Hlth Sci Ctr Houston United States 2024 – 2029

ABSTRACT I am an Assistant Professor at the School of Nursing at the University of Texas Medical Branch (UTMB) in Galveston, Texas. The purpose of this resubmitted K23 Mentored Pat...

$1.5M
USD
Active TRAINING, INDIVIDUAL
Neural mechanisms of impaired postural control in people with Parkinson's disease
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND S... University of Minnesota United States 2024 – 2027

PROJECT SUMMARY Parkinson’s disease (PD) is a prominent neurodegenerative disease with over 90,000 cases being diagnosed annually. Little is known about the pathogenesis of abnorma...

$470.1K
USD
Active NON-SBIR/STTR RPGS
Blood Gas Analysis Without the Laboratory
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Massachusetts General Hospital United States 2024 – 2028

Project Summary/Abstract Blood gas analysis is a cornerstone of modern critical care medicine, providing essential insights into a patient's respiratory and metabolic status....

$7.36M
USD
Active TRAINING, INDIVIDUAL
Spatiotemporal and molecular determinants of autoimmune T cell stemness and differentiation in type I diabetes
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... Weill Medical Coll of Cornell Univ United States 2024 – 2027

PROJECT SUMMARY Type I Diabetes (T1D) is a T cell mediated autoimmune which is dramatically increasing in incidence. The pathogenesis of T1D is complex and involves the infiltratio...

$489.7K
USD
Active TRAINING, INDIVIDUAL
Engineering Immune Engagers
NATIONAL CANCER INSTITUTE University of Minnesota United States 2024 – 2028

PROJECT SUMMARY/ABSTRACT Natural killer (NK) cell engagers are a promising anticancer therapy that potently leverages the immune system while providing an exceptional safety profil...

$432.6K
USD
Completed SBIR-STTR RPGS
Novel Digital Health Platform with Virtual Health Coach for Improving Perioperative Patient Outcomes and Care Coordination
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE Pip Care, Inc United States 2024 – 2025

SUMMARY In the US, 48 million surgeries are performed annually. Despite medical and surgical advancements, postoperative complications are the third leading cause of death. Periope...

$3.02M
USD
Completed NON-SBIR/STTR RPGS
Supportive and restrictive factors and mental health in LGBT adolescent and young adult populations
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD... Harvard Pilgrim Health Care, Inc United States 2024 – 2025

PROJECT SUMMARY/ABSTRACT An unprecedented number of new policies across the US threaten the rights of lesbian, gay, bisexual, and transgender (LGBT) populations. In 2023, >500 d...

$8.39M
USD
Active Communications
Feasibility Study - Bangladesh International Submarine Cable, through Enterprise - United States Unknown
Trade and Development Agency Enterprise - United States Other Bangladesh 2024 – 2027

A USTDA grant funds a feasibility study (Study) for CdNet Communications to support the development of the proposed Bangladesh International Submarine Cable (Bagha-1), a subsea cab...

$1.92M
USD
Active Operating Expenses
DOS Claims, Income, and Refunds
Department of State Enterprise - United States Other Cameroon 2024 – 2026

Administrative costs and operating expenses of DOS contributing to Claims, Income, and Refunds.

$43K
USD
Active Conflict, Peace, and Security
DoD Excess Defense Articles, Grant Authority
Department of Defense U.S. Government - Department of Defense Israel 2024 – 2029

HEADSET-MICROPHONE [Quantity Delivered: 6].

$9.7K
USD
Active Conflict, Peace, and Security
DoD Excess Defense Articles, Grant Authority
Department of Defense U.S. Government - Department of Defense Israel 2024 – 2029

INTRENCHING TOOL,HAND [Quantity Delivered: 53].

$2K
USD