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606,025 grants found
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Supporting Elementary Students’ Self-Regulated Learning and Fraction Knowledge
An important goal of education is to help children independently control their own learning. To be able to self-control their learning, children should have a good sense of what th...
Tensor-valued finite elements and applications
Tensor-valued functions are crucial mathematical abstractions in many areas of science. They are indispensable in modeling solids, fluids, electromagnetics, and even the spacetime...
Modeling the Coupled Dynamics of Groundwater, Subglacial Hydrology and Ice Sheets
Ice sheets lose ice mass through gravity-driven flow to the ocean where ice breaks into icebergs and melts, contributing to global sea level rise. Water commonly found at the base...
REU Site: Undergraduate Research in Physics at the University of South Carolina
This award supports the Research Experience for Undergraduates (REU) site in Physics at the University of South Carolina. The site engages ten undergraduate students per year for t...
Collaborative Research: What Controls the Mobility of the Heat Producing Elements in Continental Crust?
Silicon-rich continental crust is unique to Earth and is critical for habitability, but the processes that drive the long-term stability of this crust are unclear. The most endurin...
Cancer Research UK Newcastle Centre
Cancer Research UK Newcastle Centre Non-Clinical Training Award
An evolutionary study of head and neck cancer before and following radiotherapy
BACKGROUND Head and Neck cancer (HNC) is the seventh most common cancer globally, affecting ~660,000 patients per year worldwide, with a 50% mortality rate. Both incidence and mort...
Repurposing statins for precision prevention of PTEN- prostate cancer
Background: Prostate cancer is commonly diagnosed and accounts for one in seven male cancer deaths in the UK. Strikingly little is known about its aetiology, a significant barrier...
Investigating deprivation-specific and ethnic inequalities in adherence to endocrine therapy in women with ER+ve breast cancer: can these explain disparities in survival?
Background: Breast cancer survival is lower in women from deprived areas and, to a lesser extent, Black women. The reasons for these disparities are unclear, but differential treat...
Defining the roles and therapeutic potential of C-type natriuretic peptide in the cardiac and vascular dysfunction underpinning heart failure with preserved ejection fraction
Left ventricular (LV) remodelling occurs in response to pressure-overload or injury as an adaptive, compensatory mechanism to normalise wall stress and preserve cardiac output.Howe...
Seefeld Meeting on Protein Modularity
The concept of modularity unifies biology across scales from protein sequence- based modularity to systems level modularity.Biological systems evolve by duplicating and diversifyin...
Understanding the role of RNA modifications in myeloid leukaemogenesis
Epitranscriptomics, the modulation of RNA function via its chemical modification, has emerged as a pervasive new mechanism of gene regulation. The role of the epitranscriptome on s...
Elucidating novel immune evasion strategies of Candida albicans
Innate immunity is key for protection against fungal pathogens, providing selective pressure on fungi to evolve immune evasion strategies.Candida albicans is a commensal and opport...
High-throughput Behavioural Phenotyping to Identify Small Molecule Biologics for the Treatment of Neurological Disorders
I aim to develop a high-throughput in vivo screening platform to identify small molecule biologics capable of treating epilepsy.Using automated quantitative phenotyping, I will exp...
Living with Heat: Medical, Social and Cultural Contexts of Excess Heat in India
South Asia is no stranger to scorching temperatures, but the modern-day manifestations of heat present a unique and pressing challenge.This project proposes a comprehensive explora...
Discovering the epigenetic principles of human centromere seeding and inheritance
Chromosome segregation in mitosis and meiosis ensures the faithful deposition of the genetic complement to daughter cells.This process requires the centromere, a specialized chromo...
The contribution of health and social adversity to public and private family court proceedings: a public health approach
Families involved in family court proceedings are at the “sharp end” of a spectrum of disputes concerning their children’s upbringing.Emerging evidence shows that, whether public (...
Traceless delivery of ‘genome editors’ for treatment of severe genetic diseases
Genome editing has enormous potential to transform the future of genetic medicines. Many technologies have been developed, but further refinement is needed to improve safety and ef...
How does run-on of developmental processes contribute to ageing?
This project aims to enable therapies for healthy ageing by using our established Drosophila discovery platform for genes that coordinate development while also having detrimental...
Multimodal assessment of REM sleep dynamics and its relation to brain function in humans
Sleep is essential for health and wellbeing, but the function of rapid eye movement sleep (REMS) remains elusive.This is partly because REMS has been viewed as a homogenous state,...