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Electrophysiological biomarkers of social engagement in autism
This career development proposal's overall goal is to prepare the candidate, Alexandra Bey, MD, PhD, for an independent research career developing and utilizing electrophysiol...
High-throughput functional analyses of the genetic drivers of Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD) is a debilitating condition characterized by chronic inflammation, leading to the erosion of essential intestinal functions. The risk of developing...
A Myocardial Approach to Identify the Cause of Cardiomyopathy
PROJECT SUMMARY/ABSTRACT Cardiomyopathy is classified into ischemic cardiomyopathy, caused by coronary artery disease, or non- ischemic cardiomyopathy, caused by other factors. The...
Peripubertal Social Motivation as a Novel Risk Factor Linking Childhood Threat Exposure and Suicidal Ideation and Behavior in Preteen Girls.
Project Abstract Suicide is the second leading cause of death for youth aged 10-12. Recent data from the CDC show that girls have greater rates of STBs than boys—1 in 3 adolescent...
Improving disease subtyping and physiological characterization of adult-onset diabetes in electronic health records
ABSTRACT Diabetes is broadly classified as type 1 diabetes (T1D), with primary defect in insulin production due to autoimmune destruction of beta cells, and type 2 diabetes (T2D),...
A mixed-methods, multi-informant study of childhood suicide ideation to improve risk assessment
Abstract Despite increases in suicides among children, we have no available developmentally and culturally informed measures of childhood suicide ideation (SI) to inform risk asses...
Esophageal squamous cell cancer initiation and immune landscape remodeling
PROJECT SUMMARY/ABSTRACT Esophageal squamous cell carcinoma (ESCC) is a lethal cancer with a 10%-25% 5-year survival rate. Given the importance of early detection, the initiation p...
Resilience to Alzheimer's disease by targeting adult hippocampal neurogenesis
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD), the most common form of age-related dementia, is characterized by cognitive impairment, neurodegeneration, β-amyloid (Aβ) deposit...
Leveraging Robot-Based Haptic Dyads to Improve Community-Based Stroke Rehabilitation
PROJECT SUMMARY/ABSTRACT Disabilities, including those due to a stroke, are common among older adults worldwide, affecting about 36% of adults 65 and older in the USA.1 As the worl...
Identifying Sox9 as a marker of multipotent progenitors in Circumvallate papilla/Von Ebner's gland homeostasis
Project Summary The circumvallate papilla (CVP) and von Ebner's minor salivary glands (VEG) form a complex at the posterior midline of the tongue. The epithelial trenches of t...
Repurposing Drugs to Discover Novel Antifungals for Coccidioidomycosis
PROJECT SUMMARY Coccidioides is a fungal pathogen from the American deserts that infects people who breathe in the spores. Inside the person’s lungs, the spores develop into spheru...
The Role of Proton-Activated Chloride Channel 1 (PACC1) in Bacterial Pneumonia and Sepsis
Project Summary/Abstract Bacterial diseases constitute a major global burden, primarily due to respiratory, peritoneal, and blood infections. Our lab and others have demonstrated t...
Generative AI for synthetic data: A framework to expand health data reach for research and ensure algorithmic fairness
PROJECT SUMMARY/ABSTRACT Dr. Yan received his Ph.D. in computer science with a focus on developing privacy-preserving technologies to defend information systems against data breach...
Irradiation, Preclinical Imaging, & Microscopy (IPIM)
Project Summary/Abstract: Irradiation, Preclinical Imaging, and Microscopy The Irradiation, Preclinical Imaging, and Microscopy Shared Resource (IPIM) provides a comprehensive arra...
Immunology and Cancer Immunotherapy (ICI)
Project Summary/Abstract: Immunology and Cancer Immunotherapy The Immunology and Cancer Immunotherapy (ICI) Program brings together 21 faculty, representing seven departments at Da...
An improved low-endotoxin Clean Genome E. coli strain for production of biological products
Abstract E. coli has played a vital role in the production of recombinant proteins and plasmid DNA (pDNA) for therapeutic use since the advent of the biopharmaceutical industry. E....
Plasmonic Scattering Microscopy for high-throughput in-situ quantification of molecular binding kinetics on single cells
SUMMARY Membrane proteins play key roles in many cellular functions and are the largest class of drug targets. Measuring the molecular interactions of membrane proteins are critica...
Advancing Alzheimer's Diagnosis: MRI-Based Predictive Modeling of Alzheimer’s Disease Molecular Subtypes
PROJECT SUMMARY Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that impacts cognition and memory, imposing a substantial burden on the aging population....
Improving, validating, and interpreting amino acid substitution models
Proteins drive much of the chemistry of life. They control many of the reactions that allow organisms to survive, and they are essential structural elements that determine life’s f...
How Does the Extratropical Transition of Tropical Cyclones Impact Tornadoes and Supercells?
Landfalling hurricanes produce multiple, concurrent hazards, including tornadoes, that can compound the impact of one another. These tornadoes in landfalling hurricanes can impact...