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NIHR Development and Skills Enhancement Award
Training Award
Targeting Endosomal Receptors for Treatment of Chronic Pain
PROJECT SUMMARY/ABSTRACT Pharmacologic therapy for common forms of chronic pain is ineffective and plagued with side effects. Our long- term goal is to reveal mechanisms of pain/no...
Generation of four-chambered hearts through organoid fusions
Project Summary Congenital heart defects (CHDs) account for 1-2% of all live births in the U.S. More than 90% of these diseases are attributed to defects in heart valves and septum...
Targeting lipid-oxidizing B cells to enhance vaccine responses during immunosuppression
PROJECT SUMMARY This is a proposal for a two-year career transition award to study atypical B cells as a novel immunologic and metabolic target to improve vaccine responses in immu...
Elucidating Cutaneous Mechanosensory Circuits, from Development to Disease
Abstract Our relationship with the physical world is rich, complex, and essential for life. How does the nervous system encode component dimensions of touch –pressure, texture, vib...
Structure, function, and pharmacology of sensory receptors
Sensory receptor ion channels in somatosensory neurons are responsible for the sensory detection of stimuli such as temperature changes and irritants. This information is then tran...
Developing a single cell resolution understanding of pathogenesis and antibiotic tolerance in Staphylococcus aureus
PROJECT SUMMARY/ABSTRACT Infections caused by the Gram-positive bacterium Staphylococcus aureus are serious and frequently challenging to treat. While its propensity for developing...
Characterization of a Type VII Secretion System in Group B Streptococcus and its Role in Virulence and Immune Response
PROJECT SUMMARY Group B Streptococcus (GBS) remains the leading etiologic agent of neonatal bacterial meningitis and a major opportunistic pathogen in certain adult populations, in...
Structural Racism, Neurocognition in Reward Related Decision Making and Substance Use Risk
PROJECT SUMMARY Structural racism (SR) is defined as mutually reinforcing systems, such as income, education and housing, that disadvantage ethnoracially minoritized individuals. S...
Role of lymphatic endothelial cell NFkB signaling in adult lymph node homeostasis
PROJECT SUMMARY/ABSTRACT The proposed study is significant because we aim to understand the cellular mechanisms that regulate lymph node (LN) maintenance in aging. Aging causes LN...
Complementary and Integrative Health Approaches to Improve TBI Outcomes in Veterans
Project Summary/Abstract Background. Traumatic brain injury (TBI) is one of the most Veteran-centric conditions with few interventions with sufficient evidence and is a top researc...
Mechanistic studies of essential membrane transporters
Membrane transporters are essential for cellular life and are generally understudied compared to other membrane proteins, such as GPCR and ion channels. The long-term goal is to pu...
A Phase 2C Randomized, Controlled, Open-Label Trial of Novel Shortened Regimens for the Treatment of Isoniazid-Monoresistant TB (IMR-TB)
Project Summary/Abstract Isoniazid-monoresistant (IMR) tuberculosis (TB) comprises 1.1 million (11%) of the estimated 10 million new TB cases annually. Recent scientific advances f...
Localized Real-time Sensors for Metabolic Signaling
PROJECT SUMMARY Metabolic pathways function in response to cellular needs, but they also can direct signaling and even influence how our genes are read. If we can understand the un...
NJ ACTS: A Platform for Translational Science in New Jersey: CTSA Predoctoral T32 at Rutgers, Biomedical Health Sciences
The overarching goal of this T32 Predoctoral Training Program is to prepare future generations of translational researchers to leverage the principles of translational science to i...
Developing and Applying Accessible Computational Technologies for the Design of Small-Molecule Ligands
Project Summary/Abstract Drug discovery is tremendously costly and failure-prone, complicating advances that would otherwise im- prove human health. Computer-aided drug discovery (...
Optimising care pathways in Motor Neurone Disease for family carers: A realist evaluation.
Background: Motor Neurone Disease is an incurable disease, causing progressive muscle weakness including bulbar and respiratory dysfunction. Symptom burden has different trajectori...
HOPSCOTCH Helping Optimise Primary Care Support During Transition From Children’s Hospice Care
Research QuestionsWhat do young people with life limiting conditions and health care professionals think are the key components of an intervention to support primary care involveme...
Improving maternity and neonatal care in England: a formative evaluation of the implementation of the Core Competency Framework to improve multi-professional practice.
Research question: How has implementation of the Core Competency Framework (CCF) impacted organisational, team and individual competence in England’s maternity and neonatal units;...
Early Aortic Repair in patients Needing Endovascular/open Surgery for Type B Aortic Dissection (EARNEST): A randomised trial to assess the clinical and cost-effectiveness of thoracic endovascular aortic repair in the subacute phase after uncomplicated type B aortic dissection.
Research question: In patients with uncomplicated type B aortic dissection (uTBAD), does thoracic endovascular aortic repair (TEVAR) in the subacute phase in addition to best medic...