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606,025 grants found
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A multiscale approach to develop and apply fluoride efflux inhibitors to reverse oral dysbiosis and eliminate early childhood caries
PROJECT SUMMARY/ABSTRACT The problem: Early childhood caries (ECC) is a lead health problem affecting children. More than half a billion children worldwide have untreated tooth dec...
Applied IPV Measurement (AIM) Shortcourse
Abstract Homicide, often at the hands of intimate partners, is a leading cause of pregnancy-related death. Intimate partner violence (IPV) is a widespread and serious public health...
Restoring equity to measuring and preventing perinatal intimate partner violence (Remap-IPV)
Project Summary Maternal morbidity and mortality in the United States (US) is driven by health disparities along axes of race, poverty, disability, socio-economic and sexual gender...
Smart Foot Mat
Smart Foot Mat Abstract Eden Medical is pleased to develop the Smart Foot Mat (SfM), as a simple in-home appliance for stopping diabetic foot complications. We propose a powerful g...
Metabolism and Mitochondrial Energetics Therapy for Septic Shock
PROJECT SUMMARY / ABSTRACT Metabolic reprogramming plays a critical role in immune cell activation, differentiation, and function in response to severe sepsis. Broad defects in leu...
Orphan Non-coding RNA-based Test for Detecting Minimal Residual Disease in Resectable Non-small Cell Lung Cancer
The early detection of non-small cell lung cancer (NSCLC) is an unmet challenge in the field with significant direct impact on effectiveness of treatments and survival rate of affe...
HIV Drug Resistance in the New Antiretroviral Therapy Era in Kenya
HIV Drug Resistance in the New ART Era in Kenya Rami Kantor, MD SUMMARY Since the emergence of resistance to zidovudine in the late 1980’s, we have been in a race: an HIV drug is d...
Access to Strained Rings and Heterocycles: Applications in the Synthesis of Bacterial Metabolites and Chemical Building Blocks
Project Summary/Abstract The studies described in this proposal seek to develop strategies for the synthesis of strained rings and heterocycles for two purposes: 1) the first total...
A novel GTPase regulator governing the regenerative capacity of murine teeth
Project summary/Abstract MSCs play critical roles in tissue turnover and injury healing processes, making them highly valuable in the field of regenerative medicine. The murine tee...
Enhanced Digital Access to Bridge Social Needs and Reduce Health Disparities: The e-SINCERE Study
PROJECT SUMMARY Social context is tied to health outcomes, driving the rapid adoption of screening for tangible social needs (e.g. for housing, utilities, food) by healthcare syste...
Fibrinogen-coated albumin nanospheres for mitigation of irradiation-induced wound healing impairment in breast cancer patients.
PROJECT SUMMARY Impaired wound healing after radiation therapy is a major clinical challenge in the management of oncologic patients. The efficacy of radiotherapy in cancer treatme...
Oral and Craniofacial Bone Regeneration using MicroRNA Modulation
Project Summary More than 20% of oral squamous cell carcinoma (OSCC) patients present with bone invasion and require maxillary/mandibular continuity restoration after tumor excisio...
Continuity of User-Centered Design of a Proactive RF-Based Wearable Bladder Monitor for Toilet Training of Children with ASD/IDD
Project Abstract Urinary incontinence (UI) and difficulties with toilet training are significant and common challenges faced by childrenand young adults with autism spectrum disord...
Using Digital Health Technology to Prevent Bullying and Cyberbullying among Elementary School Students
ABSTRACT Bullying and cyberbullying are highly prevalent forms of aggressive behavior among youth of all ages and have a wide variety of negative social and mental health consequen...
The Illinois Precision Medicine Consortium (IPMC) All of Us Research Program Site
1.1. ABSTRACT The first 7-years of the All of Us Research Program (AoURP) Illinois Precision Medicine Consortium (IPMC) award has created an impetus for precision health collaborat...
Identifying inter-kingdom microbial determinants of altered immunity in HIV exposed infants
PROJECT ABSTRACT Infants born to HIV-infected mothers are at high risk for HIV acquisition. Additionally, HIV-exposed yet uninfected infants display reduced vaccine responses and i...
The Development of Youth Resilience to Neighborhood Disadvantage
Project Summary/Abstract Much of the youth resilience literature to date has focused on resilience to family adversity, with far less examining resilience to neighborhood adversity...
Grounding models of category learning in the visual experiences of young children
PROJECT SUMMARY Early word learning is a major developmental achievement that rests on a foundation of visual category learning: to learn that the word “dog” refers to a category d...
Machine Learning-enabled Classification of Extracellular Vesicles Using Nanoplasmonic Microfluidics
PROJECT SUMMARY/ABSTRACT Ovarian cancer is a diverse group of malignancies that can vary greatly in molecular biology, etiology, and presentation of symptoms. While it accounts for...
A mobile health tool to improve antibiotic stewardship among village doctors in Bangladesh
Abstract Diarrheal diseases are the among the leading cause of death in children worldwide, most of which occur in low- and middle-income countries (LMICs). The cornerstone for man...