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606,025 grants found
Showing 26,201 – 26,220 of 606,025 grants
Persistent Impacts of Adolescent THC on Microglial Function and Opioid Addiction Risk
Project Summary Adolescent cannabis use has been linked to negative long-term outcomes in humans, including increased rates of experimentation with “harder” drugs like opioids late...
Role of PL CaMKII in incubated cocaine-craving
SUMMARY Psychomotor-stimulant Use Disorder (PUD) is a chronic relapsing disorder, characterized by a high propensity for relapse even during protracted abstinence. In both humans w...
Epigenetic mechanisms of HAND pathogenesis
HIV-associated neurocognitive disorders (HAND) remain among the most prominent HIV co-morbidities in the era of ART-treated HIV infection. Persistent neuroinflammation is a recogni...
Magnetic resonance imaging methods to track Treg distribution and homing for clinical applications
PROJECT SUMMARY Regulatory T cell (Treg) infusion, alongside solid organ transplantation, is an emerging strategy which focuses on rebalancing the Treg ratio in the transplanted or...
The Effect of Pubertal Hormones on the Development of Neural Oscillatory Dynamics in Youth
Project Summary This application describes the research plan and program of study leading to a PhD as part of a combined MD- PhD Program at the University of Nebraska Medical Cente...
Penn Center for Multi-scale Molecular Mapping of the Female Reproductive System
The female reproductive system, the uterus, fallopian tubes and the ovaries, is a complex interrelated set of organs that is physiologically dynamic and not only important for fert...
Increasing the Capacity of a Community-Based Research Center to Address Opioid Use Disorder and Related Health Inequities in Urban American Indian Communities
Abstract Title: Increasing the Capacity of a Community-Based Research Center to Address Opioid Use Disorder and Related Health Inequities in Urban American Indian Communities The N...
Investigating Latinx populations’ attitudes, perceptions, and use of genomic testing
PROJECT SUMMARY Genomic medicine has transformed prevention, care, and targeted medical regiments through the milestone achievements of Human Genome Project and the advent of genet...
Radiomic biomarkers for clinical decision support that predict patient outcomes in serous ovarian carcinoma
ABSTRACT Less than a third of women diagnosed with advanced epithelial ovarian cancer (EOC) survive five years after diagnosis. Despite therapeutic improvements over time, patient...
Ribosomal RNA modification in nucleoli and disease
ABSTRACT Nucleoli produce 1-10 million ribosomes per cell. They are membraneless organelles in the nu- cleus formed by liquid-liquid phase separation (LLPS). Dysregulation of ribos...
Thrombospondin-1's role in heart failure with preserved ejection fraction (HFpEF)
PROJECT SUMMARY Heart failure with preserved ejection fraction (HFpEF) is the predominant form of heart failure and its incidence continues to rise. HFpEF disproportionately affect...
Penn TMC: Organ-Specific Project
The female reproductive system—comprised of the uterus, fallopian tubes and the ovaries—undergoes some of the most dynamic changes in structure and function of any adult human orga...
Assessment of Heterologous Prime-boost HIV Vaccine Regimen to Elicit Cross-reactive Neutralizing Antibodies Targeting HIV Fusion Peptide
The development of effective HIV vaccines and other prevention strategies relies on the use of nonhuman primates (NHPs) in preclinical studies.To meet this need, the Simian Vaccine...
Task B31: Bulk Intermediate Scaleup for Antibiotic-Resistant Drug Design
The Non-clinical Services for Development of Interventional Agents for Infectious Diseases program provides services to facilitate preclinical product development of promising ther...
Task A09: Hamster Model for Human Adenovirus
This contract provides for the development of new and refinement of existing models of infectious diseases and may include evaluation of candidate countermeasures.
Lorlatinib for untreated ALK-positive advanced non-small-cell lung cancer (Review of TA909) (ID6434)
Lung cancer falls into two main histological categories: around 80 to 85% are nonsmall-cell lung cancers (NSCLC) and the remainder are small cell lung cancers(1). NSCLC can be furt...
Cemiplimab with chemotherapy for untreated advanced or metastatic non-small-cell lung cancer (ID3949)
Lung cancer is the third most common cancer and the most common cause of cancer death in the UK accounting for 13% of all new cancer cases and 21% of all cancer deaths between 2017...
Hydromethylthionine mesylate for treating mild cognitive impairment or mild or moderate dementia caused by Alzheimers disease ID6343
Alzheimer’s disease is a progressive neurological disease and is the most common cause of dementia.1* It is thought to be caused by the abnormal build-up of proteins in and around...
Resource Center for refugees
TO CREATE A RESOURCE CENTER AND PROVIDE SERVICES TO UKRAINIAN AND NAGORNO-KARABAKH REFUGEES
Supporting community and grassroots groups to manage natural resources in Bolivia to conserve their territories and sustains their livelihoods
FY24 Amendment Blurb: This amendment provides Fundacion Semilla with an additional 18 months and $185,000 to strengthen its operational and management capacity as it scales up its...