Browse All Grants
606,025 grants found
Showing 26,141 – 26,160 of 606,025 grants
Continuous glucose monitoring for management of type 2 diabetes in pregnancy (CGM2 trial)
There is a fundamental knowledge gap in achieving maternal glycemic control sufficient to reduce maternal and neonatal morbidity and mortality in pregnant individuals with type 2 d...
Immunological mechanism of muscle-localizing self-replicating RNA vaccines
PROJECT SUMMARY/ABSTRACT As evident in the ongoing “tripledemic” of severe acute respiratory syndrome-Coronavirus-2, Respiratory Syncytial virus, and Influenza virus, as well as re...
Genetic circuits for targeted modulation of neuroinflammation
Project summary/Abstract Neuroinflammation plays a critical role in neurodegenerative diseases and cognitive functions. Current methods to study neuroinflammation in animal models...
In vitro myelination assay modeling the environment of MS lesions for predictive discovery of remyelinating therapies.
Project Summary Artificial Axon Labs Inc. (AAL), an MIT spinout, is developing a transformative drug screening platform, Artificial Axons, to discover first-in-class remyelinating...
Nurses Surviving Breast Cancer: An exploration of breast cancer diagnosis, reported lymphedema symptoms, and lifestyle status in the Nurses' Health Study Survey
Project Summary/Abstract Breast cancer-related lymphedema (BCRL) is a side-effect of anticancer treatment. Caused by damage to the lymphatic system secondary to surgery, chemothera...
Planning to implement high-quality active surveillance in new-onset favorable risk prostate cancer
Project Summary Many men with favorable-risk prostate cancer do not benefit from aggressive intervention. As a preferred alternative, active surveillance is increasingly used to sp...
SESAME: Sun Exposure and Activities after Skin CAncer: Optimization of Mhealth IntErventions
ABSTRACT There are currently 1.36 million melanoma survivors in the US, and this number is expected to increase to 1.92 million by 2030. Most melanoma patients (92%) survive 5 or m...
Support for bereaved friend and family caregivers of cancer patients
Bereaved friend and family caregivers have taken on the burden of end-of-life care for patients with cancer who die in hospice care at home. Bereavement can be emotionally devastat...
Fatty acid remodeling of the translatome during fasting and aging
PROJECT SUMMARY/ABSTRACT From Greek philosopher Plato to recent animal and human studies, fasting has been recommended as a strategy to slow down aging and reduce the risk of many...
Scientist Spotlights Partnership Program: Connecting High School Students with Science Role Models through Authoring Inclusive Curriculum Supplements
The Scientist Spotlights Partnership Program: Engaging High School Students in Exploring Biomedical Science Careers by Connecting with Counter-Stereotypical Scientists Project Summ...
Untangling the influence of distinct sources of somatosensory feedback on the neural dynamics of dexterous movement control
PROJECT SUMMARY To move successfully, we must be able to sense our bodies and our environment. This is no more evident than when participants attempt to strike a match to light a c...
Surgical drape with a releasable acrylic adhesive for atraumatic negative pressure wound therapy
Abstract – Negative pressure wound therapy (NPWT) is commonly used for the management of a broad spectrum of more than 100 indications, including chronic wounds, acute open wounds,...
An allogeneic gamma/delta armored Dual-Targeting CAR with Split Costimulatory Domains to Target Epithelial Ovarian Carcinoma
Abstract CAR T cell therapies have produced robust remissions in several hematological malignancies. However, they have not achieved the same success against solid tumors. These tr...
An AI-driven total parenteral nutrition platform for cost-effective and scientifically personalized nutrition for premature newborns
Project Summary A significant portion of newborns (6-10%) enter neonatal intensive care units (NICUs) in the U.S. and without adequate nutrition, this vulnerable population could s...
Integrating U=U into HIV counseling: a cluster-randomized efficacy trial (INTUIT 2.0)
Project Summary The elimination of HIV transmission with virally-suppressive antiretroviral therapy (ART) has provided the world with a clear path to end the HIV epidemic through t...
Research Training Program in Reproductive and Sexual Health
PROJECT SUMMARY The vision of The ASCENT Research Training Program in Sexual and Reproductive Health, Rights, and Justice (SRHRJ) is to strategically develop an innovative, interdi...
Aging-related hematopoietic stem cell intrinsic and microenvironmental signals in AML transformation
Summary Acute myeloid leukemia (AML) is a disease of the elderly that often transforms from pre-AML states of age- related clonal hematopoiesis (ARCH), myelodysplastic syndromes (M...
Core A: Administrative Core
The objective of Core A is to supervise and facilitate overall progress of the scientific work of the Program. Specifically, scientific management is combined in this Core with adm...
Project 1: Role of emergency myelopoiesis as a driver of clonal evolution in AML
PROJECT DESCRIPTION Our overall goals are to establish (i) whether the hijacking of emergency myelopoiesis (EM) pathways represents a shared mechanism of leukemogenesis in the cont...
Project 2: Microenvironmental and inflammatory mechanisms in MDM4-driven AML pathogenesis.
Project Summary/Abstract Recent studies have demonstrated the existence of preleukemic (preL) HSPC (which includes the phenomenon of age-related clonal hematopoiesis (ARCH)) in hum...