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606,025 grants found
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Structure and Mechanism of the Glucose-6-Phosphatase Catalytic Subunit 1
Project Summary This proposal requests support for investigating the structure and enzymology of glucose-6-phosphatase catalytic subunit 1 (G6PC1), an integral membrane protein of...
Ring wearable sensor use for diagnosis and monitoring of Parkinson's disease in underserved rural populations
Abstract The objective of this project is to develop an innovative ring sensor system, to be worn on the finger, for the diagnosis and monitoring of Parkinson's disease (PD) i...
Structure and function of a novel bacterial immune system
PROJECT SUMMARY The constant arms race between viruses and their hosts lead to the evolution of antiviral defense. Recent studies have revealed that bacteria developed diverse anti...
Health and economic consequences of changing federal and state policies on reproductive health.
PROJECT SUMMARY In June 2022, a decision by the U.S. Supreme Court ended the federally protected right to abortion established by Roe v Wade almost 50-years ago. In response to thi...
The Institute for Health Equity Research Catalyst Center
PROJECT SUMMARY/ABSTRACT Health disparities science has advanced significantly over the last two decades, yet complex challenges remain. Improving the health and health care of pop...
The Institute for Health Equity Research Catalyst Center
PROJECT SUMMARY/ABSTRACT The Catalyst Center is an initiative of the Institute for Health Equity Research (IHER) and will build on IHER’s commitment to addressing longstanding disp...
The Institute for Health Equity Research Catalyst Center
PROJECT SUMMARY/ABSTRACT Examining the complex drivers of health disparities requires a diverse research workforce trained in the transdisciplinary frameworks designed to address m...
The Institute for Health Equity Research Catalyst Center
PROJECT SUMMARY/ABSTRACT Community engagement is fundamental to minority health and health disparities (MH/HD) research, helping to ensure that scientific knowledge moves from inqu...
Leveraging Medical Records to Understand the Underreporting of Abortion Before and After Dobbs
ABSTRACT Dobbs v. Jackson’s Women’s Health Organization, the U.S. Supreme Court’s 2022 reversal of Roe v. Wade, is the most consequential policy change for maternal and child healt...
Development of an Environmental Health Literacy Mobile Application to Reduce Toxic Environmental Exposures in Black Communities
ABSTRACT Exposures to endocrine disrupting chemicals (EDCs), including bisphenols, phthalates, and parabens, have been linked to chronic diseases,1–5 and infertility.6,7 Unfortunat...
Cultural Adaptation of Family Check-Up to Reduce Health Disparities and Improve MentalHealth among Hispanic Families
PROJECT SUMMARY Mental health problems have increased substantially in the last decade, and Hispanic youths’ experiences of racism and marginalization increases risk for internaliz...
Mucus-degrading intestinal bacteria and toxicities of hematopoietic cell transplantation
OVERALL PROGRAM SUMMARY: Mucus-degrading intestinal bacteria and toxicities of hematopoietic cell transplantation The microbial community (microbiota) in the human gut plays a cent...
Administrative, biospecimen and biostatistical core
SUMMARY CORE A: Administrative, Biostatistics, Clinical and Bionutrition Core The Administrative, Biostatistics, Clinical and Bionutrition Core of this revised application will pro...
Genetics Core for Mucin Degrading Bacteria
SUMMARY CORE B: Genetics Core for Mucin Degrading Bacteria The intestinal microbiota comprises diverse bacteria, a subset of which are capable of degrading the host-derived mucins...
Mucin preserving strategies to reduce allo HCT toxicities
PROJECT 1 SUMMARY: Mucin-preserving strategies to reduce allo HCT toxicities Allogeneic hematopoietic cell transplantation (allo HCT) is a standard therapy for a variety of benign...
Akkermansia muciniphila mucolytic and immunomodulatory properties and intestinal GVHD
PROJECT 2: SUMMARY There’s emerging evidence that the genetic diversity of the mucophylic gut commensal Akkermansia muciniphila contribute to this microbe’s overall impact on human...
Dietary fiber, mucin-degrading Bacteroides, and intestinal GVHD
Summary Diet and nutrition are central to the treatment and prevention of many diseases. Diet is also a convenient, non- invasive lever to manipulate the composition and physiology...
Developing RNP-MaP into a broad-spectrum toolset for discovery, definition, and drug targeting of RNA-protein complexes in live cells
ABSTRACT My laboratory is interested in how interactions between RNA and RNA-binding proteins drive diverse biology and disease, and how these RNA-protein complexes might be target...
A community driven modeling approach for identifying community & policy-level interventions to address the impact of structural racism and discrimination on adolescent substance use and mental health
Project Summary Our overarching goal is to identify and assess policy and community-level interventions that counteract the effects of SRD within neighborhoods, schools, and peer n...
Improving Perinatal Mental Health among Latinas through a Culturally Adapted, Multi-Level Intervention
ABSTRACT Summary: Maternal morbidity and mortality are at an all-time high in Texas, particularly among Latina women. One major contributor to this public health crisis is under-tr...