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The FICCAH Study: Addressing the Fossil fuel Industry’s role in driving Climate Change And Health inequalities: A multi-method youth participatory project using a structural racism lens
Research question What would a youth-led strategy addressing the role of the fossil fuel industry in driving climate change and health inequalities in England include? Background C...
Mechanisms of Mindfulness Meditation and Self-Hypnosis for Pain in Older Adults with Chronic Pain
Abstract Chronic pain is common and often inadequately treated in older individuals. Although opioids are often used to treat chronic pain, their use in older adults is associated...
Olfactory targets of alcohol use disorder medications
Project Summary Alcohol use disorder (AUD) is a severe public health problem. Limited FDA-approved pharmacotherapies exist for AUD, and their efficacy is often insufficient. Theref...
Caregiver-assisted pain coping skills training for dementia
Over five million persons in the United States are living with Alzheimer's disease and related dementias (referred to as “persons with dementia” or PWD). Most patients with ea...
Disc-Facet Crosstalk During Spinal Degeneration and Repair
The anterior intervertebral disc and posterior diarthrodial facet joints form what is referred to the three-joint complex of the spine, working in concert to resist large magnitude...
Cincinnati Climate Change and Health Research Center
OVERALL CENTER SUMMARY This P20 application proposes to establish the Cincinnati Climate Change and Health Research Center (C3HRC). The central theme of our proposed exploratory ce...
Administrative Core
Project Summary/Abstract The overarching goal of the Administrative Core is to transform the Center’s capacity to contribute rigorous, innovative research on climate change and hea...
Research Project-1
Project Summary/Abstract Climate change is causing a marked increase in ambient temperatures in specific regions, especially in US Midwest cities, leading to a heightened risk of h...
Community Engagement Core
COMMUNITY ENGAGEMENT CORE SUMMARY The overarching goal of the CEC is to align the research practices of the Cincinnati Climate Change and Health Research Center with the diverse cl...
Development Core
DEVELOPMENT CORE SUMMARY The overarching goal of the Development Core is to transform the capacity of our Center for climate change and health in two critical ways: First, the core...
Computational Tools for Predicting and Understanding Knee Pain Spatial Patterns
Project Abstract Osteoarthritis (OA) is the most common musculoskeletal disorder, presenting a large societal burden and affecting over 300 million worldwide. Knee pain in patients...
Searching for the Goldilocks Zone of Innate Immunity in Alzheimer's Disease
Immunoproteostasis refers to the relationship between the immune system, proteinopathies present in many neurodegenerative disorders, and brain cell dysfunction. The relevance of i...
Vaccine induction of Salmonella-specific Th1 memory cells
PROJECT SUMMARY A successful vaccine for systemic Salmonella infections will need to induce Th1 memory cells, but the tissue location and required functionality of these cells is p...
Generation and characterization of a small RNA mutant library in Neisseria gonorrhea
PROJECT SUMMARY/ABSTRACT Gonorrhea, caused by the Gram-negative bacteria Neisseria gonorrhoeae (NGO), is one of the most prevalent sexually transmitted infections worldwide. In 201...
Validation of Closed-Loop Prefrontal Transcranial Magnetic Stimulation in a Non-Human Primate Model
Abstract This project aims to advance transcranial magnetic stimulation (TMS) technologies for psychiatric disorders. TMS outcomes vary among participants, likely due to a lack of...
Development and Testing of BAJJAJJA: An Intervention to Promote Economic Empowerment and Health of Grandmothers who Provide Primary Care for Grandchildren in Uganda
PROJECT SUMMARY/ABSTRACT The proposed K01 award describes a research training program for Dr. Schola Matovu, an Assistant Professor at the University of Utah College of Nursing. He...
Enlace Familiar: Combating Mental Health Stigma, Improving Mental Health Literacy, Supporting Mental Health Discussions at Home, and Access to care among Latinx Adolescents from Mixed Status Families
ABSTRACT Latinx adolescents from mixed-status families (where one or both parents are undocumented) comprise the ethnic-racial group with the highest rates of depressive symptoms,...
Structural investigations of coronavirus spike protein
PROJECT SUMMARY The spike (S) protein decorates the surface of coronavirus (CoV) particles such as SARS-CoV-2 and enables CoV's to enter and infect host cells. The S protein i...
The peripheral blood microbiome as a potential biomarker of knee osteoarthritis
Project Summary / Abstract The objective of the proposed research is to better understand how peripheral blood microbiome patterns are associatedwith knee osteoarthritis (OA). Our...
Investigating Neisseria gonorrhoeae double-stranded bacteriophage
Abstract Neisseria gonorrhoeae is an obligate human pathogenic species. A few reports in the literature describe three or four genomic islands encoding potential double-stranded ph...