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20,252 grants found
Showing 18,061 – 18,080 of 20,252 grants
(PQ6) Mesenchymal stem cell based and immunocompetent mouse models of HIV/AIDS KSHV-driven sarcomagenesis
Kaposi?s sarcoma is an HIV/ AIDS associated malignancy that in spite of the implementation of ART causes significant morbidity and mortality.Pathogenesis based design and testing o...
Developmental therapy for selectively targeting MEK-ERK pathway in cancer cells and tumor stromal compartment
Project Summary/Abstract Carcinogenic mutations in the RAS-RAF-MEK-ERK pathway are present in 46% of all human cancers. This has inspired the successful development of many small m...
Highly multiplexed live-cell GPCR arrays for drug discovery in glioma.
Project summary/Abstract We will deploy an automated multiplexed live-cell assay to detect and quantify agonist and inverse-agonist activities against 55 GPCRs known to be upregula...
Bioengineered Prostate-on Chip: Mechanisms of Stromal Dysregulation in Prostate Cancer
ABSTRACT It is well accepted that intrinsic action of the androgen receptor (AR) within the prostate epithelium drives prostate cancer proliferation and survival. Less appreciated...
Developmental therapy for selectively targeting MEK-ERK pathway in cancer cells and tumor stromal compartment
Project Summary/Abstract Carcinogenic mutations in the RAS-RAF-MEK-ERK pathway are present in 46% of all human cancers. This has inspired the successful development of many small m...
Bioengineered Prostate-on Chip: Mechanisms of Stromal Dysregulation in Prostate Cancer
ABSTRACT It is well accepted that intrinsic action of the androgen receptor (AR) within the prostate epithelium drives prostate cancer proliferation and survival. Less appreciated...
Developmental therapy for selectively targeting MEK-ERK pathway in cancer cells and tumor stromal compartment
Project Summary/Abstract Carcinogenic mutations in the RAS-RAF-MEK-ERK pathway are present in 46% of all human cancers. This has inspired the successful development of many small m...
Bioengineered Prostate-on Chip: Mechanisms of Stromal Dysregulation in Prostate Cancer
ABSTRACT It is well accepted that intrinsic action of the androgen receptor (AR) within the prostate epithelium drives prostate cancer proliferation and survival. Less appreciated...
Developmental therapy for selectively targeting MEK-ERK pathway in cancer cells and tumor stromal compartment
Project Summary/Abstract Carcinogenic mutations in the RAS-RAF-MEK-ERK pathway are present in 46% of all human cancers. This has inspired the successful development of many small m...
Bioengineered Prostate-on Chip: Mechanisms of Stromal Dysregulation in Prostate Cancer
ABSTRACT It is well accepted that intrinsic action of the androgen receptor (AR) within the prostate epithelium drives prostate cancer proliferation and survival. Less appreciated...
Investigating the IL-1R Pathway in Anaplastic Large Cell Lymphoma for Targeted Therapy
PROJECT SUMMARY Anaplastic large cell lymphoma (ALCL) comprises a collection of mature T-cell neoplasms that share elevated expression of CD30 and anaplastic cytology. ALCL subtype...
Sustaining the Integrative Imaging Informatics for Cancer Research (I3CR) Center
Abstract Artificial intelligence (AI) and other computationally intensive methods have the potential to revolutionize cancer imaging research and patient care.The broad adoption of...
Evaluating a Novel Autophagy Inhibitor in KRAS-Driven Lung Cancer
PROJECT SUMMARY Autophagy is an intracellular recycling process controlled by the kinase ULK1 that is important in the survival and growth of KRAS mutant lung tumors.Our team and o...
Supplement to AWD32581 - Fritz fellowship F32CA220935
PROJECT SUMMARY No changes during requested extension period.
P53, DNA Repair Imbalance, and Immune Response in Breast Cancer Mortality Disparities
PROJECT SUMMARY/ABSTRACT Genome stability is determined by multiple DNA repair pathways, including both error-prone and error-free mechanisms. Mutations can be caused by inactivati...
P53, DNA Repair Imbalance, and Immune Response in Breast Cancer Mortality Disparities
PROJECT SUMMARY/ABSTRACT Genome stability is determined by multiple DNA repair pathways, including both error-prone and error-free mechanisms. Mutations can be caused by inactivati...
Targeting the metastasis initiating cell in undifferentiated pleomorphic sarcoma
Undifferentiated pleomorphic sarcoma (UPS) is a soft tissue sarcoma, with one of the worst prognosis.We will build on our discovery that UPS contains a small subpopulation of metas...
Investigating the IL-1R Pathway in Anaplastic Large Cell Lymphoma for Targeted Therapy
PROJECT SUMMARY Anaplastic large cell lymphoma (ALCL) comprises a collection of mature T-cell neoplasms that share elevated expression of CD30 and anaplastic cytology. ALCL subtype...
Sustaining the Integrative Imaging Informatics for Cancer Research (I3CR) Center
Abstract Artificial intelligence (AI) and other computationally intensive methods have the potential to revolutionize cancer imaging research and patient care. The broad adoption o...
Targeting the metastasis initiating cell in undifferentiated pleomorphic sarcoma
Undifferentiated pleomorphic sarcoma (UPS) is a soft tissue sarcoma, with one of the worst prognosis. We will build on our discovery that UPS contains a small subpopulation of meta...