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Highly multiplexed live-cell GPCR arrays for drug discovery in glioma.
| Funder | NATIONAL CANCER INSTITUTE |
|---|---|
| Recipient Organization | Spectragenetics |
| Country | United States |
| Start Date | Apr 07, 2021 |
| End Date | May 31, 2022 |
| Duration | 419 days |
| Number of Grantees | 1 |
| Roles | Principal Investigator |
| Data Source | NIH (US) |
| Grant ID | 10139682 |
Grant Description
Project summary/Abstract We will deploy an automated multiplexed live-cell assay to detect and quantify agonist and inverse-agonist activities against 55 GPCRs known to be upregulated or downregulated in human gliomas.
The assay will be used to look for the secretion of effectors for any of the 55 receptors by 48 established glioma cell lines of the Human Glioblastoma Cell Culture Resource.
This endeavor may yield new leads towards the development of anti-tumor therapeutics, and will provide a platform for detecting such leads in resected tumor tissue and in chemical or biologic libraries in future experiments.
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Spectragenetics
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