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20,252 grants found
Showing 17,221 – 17,240 of 20,252 grants
OPERATION & SUPPORT OF THE CTEP PROTOCOL AND INFORMATION OFFICE (PIO)
The Protocol Information Office (PIO), Cancer Therapy Evaluation Program (CTEP), Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI) is responsible f...
Relationship of bias and negative birth outcomes
Perinatal smoking negatively affects the baby and mother as well as healthcare costs; yet, up to one third of women who smoke continue to do so during pregnancy. We tested an SMS t...
HTS for the discovery of activators of NK cell cytotoxicity
Abstract Natural killer (NK) cells are lymphocytes that are capable of killing malignant cells without antigen-specific receptor recognition. Due to this property, NK cells have be...
Treating colon cancer by regulating intestinal immunity through microbial metabolism
PROJECT SUMMARY Colorectal cancer (CRC) is profoundly affected by the intestinal immune system and the intestinal microbiome, which can exert both pro- and anti-cancer effects that...
Aggressive colorectal cancer subtypes and social disadvantage in a racially diverse cohort
ABSTRACT While overall colorectal cancer (CRC) incidence and mortality have declined over the last several decades, CRC incidence and mortality rates continue to be higher in Afric...
Direct therapeutic intervention of the tumor microenvironment with a potent inhibitor of fibronectin assembly
PROJECT SUMMARY Among the hallmarks of cancer, the extracellular matrix contributes to the regulation of each of the hallmark principles underlying tumor progression.Importantly, e...
Elucidating the role of the SWI/SNF complex in mediating hormone therapy resistance in breast cancer
PROJECT SUMMARY Approximately 70% of breast cancers express estrogen receptor (ER) and are treated typically with endocrine therapy.Despite the clinical benefit obtained from sever...
Socio-environmental context in monoclonal gammopathy of undetermined significance (MGUS) disparities
ABSTRACT Compared to non-Hispanic whites, African Americans have a more than 2-fold higher incidence of multiple myeloma (MM) and its asymptomatic precursor condition, monoclonal g...
Impact of e-cigarette characteristics and marketing on tobacco use and health: A longitudinal study among U.S. youth and adults
PROJECT SUMMARY/ABSTRACT E-cigarette use has increased rapidly, particularly among youth and young adults. The appealing flavors are a primary reason for young people to initiate a...
The Effects of IQOS Use on Cigarette Smoking Behavior
PROJECT SUMMARY Despite increased morbidity and mortality, 34 million adults in the United States smoke combustible cigarettes.Heat-not-burn (HNB) tobacco products are an emerging...
Malawi Cancer Outcomes Research Program (M-CORP)
PROJECT SUMMARY Globally, there are more deaths from cancer than from HIV, tuberculosis, and malaria combined.In 2018, there were more than 18 million new cancer cases and 9.5 mill...
Impact of sugary drinks on gut microbiota and development of young-onset colorectal cancer
Project Summary One of the most disturbing phenomena in colorectal cancer (CRC) in the US in the past four decades is its increasing incidence and mortality in adults younger than...
Clinical trial data analysis to design novel treatment regimens in oncology
Project summary Despite the recent development of new treatment modalities in oncology, the overall approval rate for cancer therapeutics is low: only 3% of drugs tested in a phase...
Bacterial Rogue Methyltransferases Inducing Human Epimutations
PROJECT SUMMARY: DNA methylation is dysregulated in every form of cancer.While there is substantial knowledge regarding the location and function of abnormal DNA methylation across...
Elucidating the role of gut, blood, and tumor microbiota in brain metastasis
Project Summary Brain metastasis is a substantial clinical challenge associated with rising incidence and significant morbidity and mortality.Understanding the mechanisms underlyin...
Role of IRF2BP2 in Tumor Immune Evasion
PROJECT ABSTRACT Understanding the tumor microenvironment (TME) and the prognostic relevance of the cells contributing to it is vital for developing novel treatments for medullobla...
Characterizing and Targeting BAX- and BAK-Dependent Cell Death in Cancer
PROJECT SUMMARY The incorporation of Immune checkpoint blockade into anticancer armamentarium has revolutionized cancer therapy in recent years, with FDA approved agents in multipl...
Understanding the Mechanisms of DC Licensing in CD8 T Cell Priming
ABSTRACT Effective responses to viruses, intracellular pathogens and tumors rely on the successful expansion and arming of cytolytic CD8 T cells from a naïve and quiescent T cell r...
2021 Summer's Way Rhabdomyosarcoma Workshop. Bringing researchers, clinicians, industry scientists, families, and foundations together to collaboratively advace RMS research and therapeutics.
Project Summary Abstract/2021 Summer?s Way Rhabdomyosarcoma Workshop Rhabdomyosarcoma (RMS) is a rare childhood cancer associated with a high mortality rate. Treatment options are...
Validation of predictive liquid biomarkers for patients with metastatic prostate cancer
Project Summary/Abstract The University of Wisconsin Carbone Cancer Center (UWCCC), Duke University and Memorial Sloan Kettering Cancer Center (MSKCC) seek support for establishing...