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20,252 grants found
Showing 16,861 – 16,880 of 20,252 grants
Adapting and Testing a Novel Self-Compassion Intervention to Reduce Lung Cancer Stigma
Project Summary Given advances in screening and treatment, the number of people in the U.S. living with lung cancer is expected to increase by 25% (from 571,340 to 724,610) by 2030...
Do Tumor-Immune Interactions Prime Systemic Tolerance of Triple-Negative Breast Cancer Brain Metastases?
PROJECT SUMMARY / ABSTRACT It is widely estimated that 90% of cancer-related deaths are caused by metastasis. This statistic underscores our inability to manage cancer once it diss...
Molecular Mechanisms of APOBEC-Induced Mutagenesis in Cancer
PROJECT SUMMARY Tumor heterogeneity is the main cause of resistance to current chemotherapy drugs as well as metastasis development, leading to patients' death. Within the sam...
Improving the translational value of head and neck cancer patient-in-mouse models
Project Abstract: Patient-derived model systems are commonly used to study tumor biology and test novel treatments for head and neck cancer. These models are established using pati...
Urine based circulating tumor DNA analysis
ABSTRACT Urine is an underappreciated source for systemic circulating tumor DNA in patients with non-genitourinary cancers. Based on recent data suggesting that blood-based HPV DNA...
Targeting the Circadian Rhythm in Glioblastoma Stem Cells (R01CA238662)
Glioblastomas rank among the most lethal of all human cancers. Current therapy includes maximal surgical resection, followed by combined radiotherapy and oral chemotherapy (temozol...
Characterizing the XRN1 exoribonuclease as a therapeutic target in non-small cell lung cancer
PROJECT SUMMARY/ABSTRACT Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide. The development of targeted molecular therapies that inhibit m...
Investigating apoptotic priming as a determinant of sensitivity to leukemia-directed therapies
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is a lethal blood cancer characterized by a clonal expansion of precursor blood- forming cells. Intensive chemotherapy has bee...
Genetic dissection of oncogenic Kras signaling
ABSTRACT Lung cancer is a prevalent cancer type that leads to more deaths than the next four major cancer types combined. KRAS is one of the most frequent oncogenes in human lung c...
Cause and therapeutic impact of DNA-protein crosslink repair defect in myeloid leukemias
ABSTRACT Acute myeloid leukemias (AMLs) are a genetically heterogeneous group of clonal hematopoietic disorders characterized by accumulation of immature non-lymphoid marrow progen...
Targeting an unrecognized checkpoint on T cell function in tumors
PROJECT SUMMARY/ABSTRACT A diverse accumulation of infiltrating immune cells is a prominent feature of nearly all cancers1. By directing the effector functions of cancer-killing T...
High-Throughput Screen for the Oncoprotein MYC
ABSTRACT MYC is a key transcriptional regulator involved in cellular proliferation and has established roles in transcriptional elongation and initiation, microRNA regulation, apop...
Decision Support for Multigene Panel Testing and Family Risk Communication among Racially/Ethnically Diverse Young Breast Cancer Survivors
Project Summary/Abstract: The introduction of multi-gene panel testing for hereditary breast and ovarian cancer (HBOC) syndrome has rapidly changed the clinical approach to genetic...
Defining PARP Inhibitor Response and Resistance in Prostate Cancer
PROJECT SUMMARY/ABSTRACT The objective of this K01 award is to promote the development of Dr. Alan Lombard into an independent prostate cancer researcher. The proposed project will...
RNase H2 is a novel therapeutic target in triple negative breast cancer
Project Summary Due to their hyperproliferative nature and intrinsic genomic instability, triple-negative breast cancer (TNBC) cells exhibit high levels of replication stress, whic...
Discovery and verification of methylated circulating tumor DNA markers for the detection of colorectal cancer in subjects under 50 years of age
Abstract In recent years, the incidence of colorectal cancer (CRC) under the age of 50-years has increased significantly and population-based screening is currently not offered to...
Defining mechanisms of thalidomide analog resistance
PROJECT SUMMARY Thalidomide and its analogs, lenalidomide and pomalidomide, have revolutionized the treatment of patients with multiple myeloma (MM) and other hematologic malignanc...
Developing novel bispecific antibodies for cancer treatment
PROJECT SUMMARY The overall goal of this project is to improve activities of therapeutic antibodies against cancer metastasis through developing novel bispecific antibodies (BsAbs)...
Enhancing the efficacy of androgen signaling inhibitors in prostate cancer
Title: Enhancing the efficacy of androgen signaling inhibitors in prostate cancer Abstract It has been documented that androgen receptor (AR) signaling remains to play a critical r...
THE ROLE OF SELENOPROTEIN SYNTHESIS PATHWAY IN ACUTE MYELOID LEUKEMIA
AML is the most common acute leukemia in adults, and it appears increasingly with age. Despite overall improvement in the treatment of leukemia, AML still carries a devastating pro...