Browse All Grants
20,252 grants found
Showing 16,621 – 16,640 of 20,252 grants
Impact of Host NF-kB Signaling in Radiation Therapy
PROJECT SUMMARY / ABSTRACT Investigation of cytoplasmic-to-nuclear (C→N) NF-κB signaling pathways induced by various cell surface receptors has significantly expanded the knowledge...
Novel DNA damage response therapeutics targeting replication protein A
Novel DNA damage response therapeutics targeting replication protein A Abstract The DNA damage response (DDR) is now considered a tractable pathway to target for cancer therapy. Th...
Structural Surfaceomics: A Strategy for Immunotherapy Target Discovery
PROJECT SUMMARY/ABSTRACT Engineered cellular therapies, such as CAR-T cells, hold great promise as “living drugs”. However, the application of this approach beyond B-cell origin ma...
THE ROLE OF SELENOPROTEIN SYNTHESIS PATHWAY IN ACUTE MYELOID LEUKEMIA
AML is the most common acute leukemia in adults, and it appears increasingly with age. Despite overall improvement in the treatment of leukemia, AML still carries a devastating pro...
Leveraging Tumor Suppressor Inactivation for Osteosarcoma Therapy
PROJECT SUMMARY Osteosarcoma (OS) is the most common malignant bone tumor, found in the pediatric population and often leads to death due to tumor progression and metastasis. Despi...
Therapeutic potential of targeting DNA repair deficiency in TSC
PROJECT SUMMARY/ ABSTRACT Using next-generation sequencing, researchers have identified somatic mutations as essential for tumor etiology and evolution. We now know that many cance...
Integrative Functional Profiling of Tumor-Derived Extracellular Vesicles
PROJECT SUMMARY Clinical implementation of Precision Medicine faces major challenges in precision disease stratification and staging, determining optimal treatment, monitoring ther...
Integrated ligand and target discovery by chemical proteomics for glioblastoma treatment.
PROJECT SUMMARY The epidermal growth factor (EGFR) oncogene is amplified and drives tumor growth in 55% of adult glioblastomas (GBMs). However, EGFR inhibitors have failed to demon...
Oligomannose antigens as conserved immunological targets of Non-Hodgkin lymphomas
PROJECT SUMMARY Non-Hodgkin lymphoma (NHL) is primarily of B-cell origin but is substantially heterogeneous, which makes developing a tumor-specific immunotherapy for it difficult....
Discovery and verification of methylated circulating tumor DNA markers for the detection of colorectal cancer in subjects under 50 years of age
Abstract In recent years, the incidence of colorectal cancer (CRC) under the age of 50-years has increased significantly and population-based screening is currently not offered to...
Pediatric Preclinical In Vivo Testing Center for Pediatric Sarcoma and Other Solid Tumors
ABSTRACT With recent enactment of the Research to Accelerate Cures and Equity (RACE) for Children Act, there is a growing impetus to identify pediatric indications for molecularly...
Adapting and implementing evidence-based breast cancer follow-up in primary care
PROJECT SUMMARY/ABSTRACT Breast cancer survivors are a growing population and their symptom burden is significant. Despite growing evidence on specific symptoms and risk management...
Targeting CDK6 expression/activity in Ph+ and Ph1-like acute lymphoblastic leukemia (ALL)
Abstract Philadelphia-positive acute lymhoblastic leukemia (Ph+ ALL) and Ph1-like B-ALL account for most cases of “high-risk” adult B-ALL. Current therapies with tyrosine kinase in...
Increasing aerobic and muscle-strengthening physical activity in Latinas via interactive web-based technology
ABSTRACT Cancer is the leading cause of death among Latinos in the U.S. While engaging in a physically active lifestyle is one of the most important modifiable behaviors for reduci...
Pentraxin-3 in the Pathogenesis and Management of Triple-Negative Breast Cancer
SUMMARY Background. Triple-negative breast cancers (TNBCs) present with advanced histological grade and aggressive clinical behavior. They are overwhelmingly unresponsive to conven...
Stroma penetrating and immune modulating nanoparticles for image-guided therapy of pancreatic cancer
Project Summary Resistance to therapy is the major challenge for the treatment of pancreatic cancer. Despite recent successes in immune checkpoint therapy of several human cancer t...
Germline and Somatic Genomic Studies in CLL Minorities
African Americans are significantly underrepresented in cancer research. Although there have been recent efforts toward more inclusion of African Americans in cancer research, subs...
Hexokinase 2 and cancer therapy
Cancer cells are metabolically different from normal matching cells, and this is manifested by the high rate of glucose metabolism in cancer cells. The high rate of glucose metabol...
Targeting the Metabolic Regulator SIRT5 in Acute Myeloid Leukemia
Supported by R01CA254354: Targeting the Metabolic Regulator SIRT5 in Acute Myeloid Leukemia (AML) we have reported that the lysine deacylase SIRT5 is a druggable metabolic target i...
Elucidating the molecular mechanisms of PRMT5i response and resistance in LUAD and PDAC
Project Summary Protein arginine methyltransferase 5 (PRMT5) is part of a methyltransferase complex that symmetrically dimethylates arginine residues in a wide range of proteins re...