Targeting the Metabolic Regulator SIRT5 in Acute Myeloid Leukemia

Supported by R01CA254354: Targeting the Metabolic Regulator SIRT5 in Acute Myeloid Leukemia (AML) we have reported that the lysine deacylase SIRT5 is a druggable metabolic target in AML (Yan et al. Blood Cancer Discov. 2021;2(3):266-287). Our new preliminary data suggest that the role of SIRT5 may extend to

acute lymphoblastic leukemia (ALL), including relapsed/refractory (R/R) ALL. ALL is the most common cancer in children. After a peak at age 9, incidence initially declines, but then rises steadily after the age of 30. Most ALL cases originate from B-lymphoid precursor cells (B-ALL), but 15% are of T cell origin (T-ALL). Aggressive

chemotherapy has greatly improved outcome in children, but often at the expense of long-term functional impairment. In contrast, long-term survival in adults is