Browse All Grants
20,252 grants found
Showing 1,481 – 1,500 of 20,252 grants
A soft magnetoelastic microneedle patch for rapid skin cancer screening
PROJECT SUMMARY Over 2.5 million skin cancers are diagnosed annually in the United States, more than all other forms of cancers combined. Early diagnosis is critical; thus, we prop...
Mechanism and functional consequences of dietary lipids in lineage specification and tumor growth in oncohistone gliomas
PROJECT SUMMARY: Mechanism and functional consequences of dietary lipids in lineage specification and tumor growth in oncohistone gliomas Diffuse midline gliomas (DMGs) are the mos...
Diet-mediated regulation of fatty acid saturation impacts cancer progression and therapy responses.
Project Summary/Abstract Many “anti-cancer” diets are promoted in popular culture for cancer prevention and treatment, reflecting the enthusiasm of patients, clinicians, and resear...
The Role of HA Remodeling and Mesenchymal Transitions in Glioblastoma
PROJECT SUMMARY Glioblastoma (GBM) is a deadly disease with no effective therapy and is associated with one of the worst 5-year survival rates of all human cancers. Current treatme...
Dissecting Integrated Cellular Programs Promoting Platinum Resistance and Progression in Bladder Cancer
PROJECT SUMMARY Platinum-based chemotherapy regimens improve survival for patients with muscle-invasive (MIBC) and metastatic bladder cancer (BC), and this approach remains the the...
Transcatheter Intra-Arterial Delivery of Oriented Anti-PD-L1 Immune checkpoint inhibitors Immobilized Nanocarriers for Local Combination Immunotherapy of Hepatocellular Carcinoma
PROJECT SUMMARY Hepatocellular carcinoma (HCC) is the 5th most common malignancy in the world and the 4th leading cause of cancer death in the US. Resection and transplantation are...
Enrichment for Tumor-derived Cell-free EBV DNA: Towards a Diagnostic Assay for Endemic Burkitt Lymphoma
PROJECT SUMMARY Endemic Burkitt lymphoma (eBL) outcomes in children with advanced stage disease are markedly inferior to those in children with early-stage disease. eBL is one of t...
Designing inducible chemotactic beacons for enhanced trafficking of CAR T cells to solid tumors
ABSTRACT CAR T cell immunotherapy has proven to be a real tour de force in treating refractory hematologic malignancies, and is being explored for treatment of solid tumors. Howeve...
Profiling and perturbing the inheritance of drug-induced metabolic states in cancer with Inheritance-Seq
Non-genetic acquired resistance has been implicated in the therapy failure of multiple cancer types. Therefore, there have been significant efforts to uncover the mechanisms regula...
DUSP2 in Negative Regulation of Cytotoxic T Cell Responses to Immunotherapy
ABSTRACT Durable tumor regression by immune checkpoint blockade (ICB) has been observed in a small cohort of cancer patients, but ICB efficacy varies widely on an individual basis....
Mechanisms of Macrophage-Mediated Immune Evasion in Residual Tumors
Abstract Oncogene targeted therapies offer a safe and effective approach to suppress cancer since these drugs spare healthy tissues by selectively targeting driver mutations in can...
Examining Physical Activity Promotion Intervention Outcomes, Barriers and Facilitators in Breast Cancer Survivors with Fatigue
Project Summary/Abstract Breast cancer is the most diagnosed cancer in women in the United States, and the population of breast cancer survivors (BCS) is growing. Cancer-related fa...
Accurate prognosis and prediction of clinical benefits of adjuvant therapy for early-stage non-small cell lung cancer
Project Summary Sostos, LLC has developed a qRT-PCR-based microfluidic 7-gene assay (CATOS-LU) that predicts recurrence or progression to metastasis of non-small cell lung cancer (...
High-Throughput Measurements of RNA-Mediated Regulation of Gene Expression and Oncogenesis
Project Summary Dysregulation of RNA-binding protein (RBP)-RNA interactions impacts the coordination of RNA fate with severe implications for human health. RBPs interact directly w...
Next-generation diagnostic approaches for HER2-low breast cancer and trastuzumab deruxtecan therapy
The current assays for assessing HER2 were “fit-for-purpose” (over 25-years ago) to identify HER2 overexpression/gene amplification and are not built to subclassify unamplified HER...
Defining protein translation dynamics in cancers with differential Myc expression
PROJECT SUMMARY Gene amplification of the oncogene Myc is associated with increased metastasis, resistance to treatment, and overall poor prognosis and survival across several canc...
Elucidating the Role of AIRE and Tumor Associated Aire-expressing Cells in Tumor Growth and Immune Evasion
PROJECT SUMMARY/ABSTRACT Autoimmune Regulator gene (AIRE) prevents autoimmunity by promoting thymic deletion of self-reactive T cells. While most studied in the thymus, AIRE is als...
Understanding and exploiting apoptotic dysregulation in ovarian cancer
PROJECT SUMMARY/ABSTRACT Death rates have decreased across many cancer types owing to improved early detection and treatment methods, but remained largely stagnant for ovarian canc...
Targeting the RNA helicase DDX6 in acute myeloid leukemia
PROJECT SUMMARY Acute myeloid leukemia (AML) is an aggressive blood cancer characterized by the accumulation of abnormal myeloid progenitors arrested in differentiation. It is the...
Unlocking the Diagnostic and Prognostic Potential of 5hmC in Urine cfDNA: Characterization of Genome-wide Landscape in Healthy Urine and Biomarker Development in Localized Bladder Cancer
PROJECT SUMMARY/ABSTRACT Epigenetic modifications play a crucial role in mammalian development, cellular differentiation, and disease, with 5-methylcytosine (5mC) being the most we...