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20,252 grants found
Showing 981 – 1,000 of 20,252 grants
Small Molecule ERG Inhibitors for Prostate Cancer
Project Summary/Abstract There is a critical need for more effective and durable prostate cancer treatments. Prostate cancer (PCa) is the most frequently diagnosed cancer among men...
Finding NEMO's Switchable MRI Signal Using Microfluidic Tumor Models
PROJECT SUMMARY Misdiagnosis is prevalent in younger women with dense breast tissue receiving breast cancer screening, resulting in missed cancers, needless follow-up testing, anxi...
SCH: Counterfactual Explanations for AI-Assisted Cancer Diagnosis and Subtypiing
Accurate diagnosis of cancer hinges on histopathological assessment, with treatment pivoting upon the tumor's morphological classification. AI models, especially deep learning...
Defining the Role of Renal Gluconeogenesis in Renal Cell Carcinoma
PROJECT SUMMARY Renal cell carcinoma is the most common primary kidney cancer, representing 90-95% of primary renal neoplasms. Our work in the parent award has identified a novel l...
Secretory Mitophagy in Cancer Metabolic Reprogramming
Tumor metabolic reprogramming is a hallmark of cancer progression, survival, and therapeutic resistance. A targetable class of cancer metabolic adaptation exploits mitophagy, a spe...
Mitophagy-Mediated Cell Death in Mammary Tumorigenesis
Project Summary Background: The metastasis of cancerous cells to distant and vital organs is responsible for in excess of 90% of cancer mortalities. Given this extraordinarily high...
Advancing Equity in Cancer Care: Investigating Health- Related Social Needs and Colonoscopy Follow-Up Among FQHC Patients
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is the second leading cause of cancer-related deaths among both men and women in the US, with screening recommended by the US Preve...
Investigating NPEPPS-mediated feedback between bladder cancer cells and peripheral neurons as a mechanism of cisplatin resistance
PROJECT SUMMARY – Parent R01 CA268055 Cisplatin (Cis)-based Neoadjuvant chemotherapy (NAC) is the standard of care prior to cystectomy, for patients with muscle-invasive bladder ca...
Behavioral Economic Approaches for Population-based Colorectal Cancer Screening
PROJECT SUMMARY/ ABSTRACT This goal of this proposal is to develop and evaluate a multi-level intervention focused on the health system, clinicians, and patients that could increas...
The role of DNA-PKcs in DNA repair, lymphocyte development, RNA metabolism and tumor suppression
Summary This supplement application seeks two years of support for Miss Angelina Li for post-baccalaureate training in the Zha laboratory. Miss Li is expected to graduate with a B....
SCH: Individualized learning and prediction for heterogeneous multimodal data from wearable devices
Recent technological advances in mobile health have catalyzed the rapid growth of large volumes of digital health data due to its potential for scientific impact and health relevan...
Analysis of a missense SNP in the aryl hydrocarbon receptor repressor gene that may disproportionately increase lung cancer risk in Black Americans
The parent grant studies a single nucleotide polymorphism (SNP) in the aryl hydrocarbon receptor repressor (AHRR) gene that may influence the lung cancer risk of Black/African Amer...
Phenotypic sorting of cancer cells to study the role and control of cell stiffness in the in vivo metastatic cascade
PROJECT SUMMARY/ABSTRACT A majority of cancer-related deaths are the result of the metastatic spread of cancer cells from their primary tumor location to distant sites in the body....
Understanding B cell immunity in Merkel cell carcinoma
PROJECT ABSTRACT Merkel cell carcinoma (MCC) is a rare, highly aggressive, neuroendocrine carcinoma of the skin. Notably, approximately half of all MCC patients with advanced or me...
The role of ERBB2 signaling in HPV-induced pathologies
Project Summary / Abstract High-risk human papillomaviruses (HPV) are a group of viral pathogens that infect and replicate in keratinocytes in the stratified squamous epithelium (S...
Defining novel mechanisms of microbiota in regulating anti-tumor responses
PROJECT SUMMARY/ABSTRACT Research: Cancer is the second leading cause of mortality in the world, with estimates as high as 1.9 million new diagnoses and 0.6 million deaths in the U...
Cancer Misinformation and Use of Complementary and Alternative Therapy (CAM) among Patients with Cancer.
Abstract Patients' exposure to cancer misinformation has grown tremendously. Research has shown that up to 30% of popular social media posts contain inaccurate information. Me...
Preclinical Efficacy of Allogeneic and Human Silicified Cancer Vaccines
SummaryCell silicification creates cellular entities that retain the cell’s innate structure and protein features; have increased resistance to heat, pressure and dehydration; and...
Protein Lipidation: Enzymology, Signaling, Therapeutics
PROJECT SUMMARY/ABSTRACT We seek funding to support participation in the 15th biennial FASEB Summer Research Conference on "Protein Lipidation: Enzymology, Signaling, and Ther...
Defining the roles for the sequence-non-specific DNA-binding domains in mammalian SWI/SNF chromatin remodeling complex assembly and function
PROJECT SUMMARY/ABSTRACT The mammalian SWI/SNF (mSWI/SNF) complexes represent a diverse family of ATP-dependent chromatin remodeling complexes (CRCs) that play critical roles in th...