Investigating NPEPPS-mediated feedback between bladder cancer cells and peripheral neurons as a mechanism of cisplatin resistance

$91.8K USD

Funder	NATIONAL CANCER INSTITUTE
Recipient Organization	Cedars-Sinai Medical Center
Country	United States
Start Date	Jul 01, 2024
End Date	Jul 31, 2026
Duration	760 days
Number of Grantees	2
Roles	Co-Investigator; Principal Investigator
Data Source	NIH (US)
Grant ID	`11063653`

Grant Description

PROJECT SUMMARY – Parent R01 CA268055 Cisplatin (Cis)-based Neoadjuvant chemotherapy (NAC) is the standard of care prior to cystectomy, for patients with muscle-invasive bladder cancer (MIBC). Up to 30% of patients respond and show no residual tumor at cystectomy with >80% survival, but “non responders” have