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20,252 grants found
Showing 661 – 680 of 20,252 grants
Building a Cancer Epidemiology Cohort to Investigate Factors Associated with Higher Risk of Colorectal Cancer among Alaska Native People
PROJECT SUMMARY/ABSTRACT Alaska Native (AN) people have the highest recorded rate of colorectal cancer (CRC) in the world with twofold higher incidence and mortality than US whites...
Structural surfaceomics to probe conformation-selective immunotherapy targets
PROJECT SUMMARY/ABSTRACT The Problem: Cellular immunotherapies targeting surface proteins are one the most exciting new modalities in cancer. However, most tumors lack surface targ...
Protein Phosphorylation in Health and Disease
Program Director/Principal Investigator (Last, First, Middle): Tagliabracci, V.S./Yaffe, M. Protein phosphorylation plays a vital role in cellular communication, regulating cellula...
Microphysiological platform for analyzing multiple myeloma's tumor microenvironment, enabling immunotherapy assessment and drug screening.
ABSTRACT The tumor microenvironment (TME) plays a critical role in hematologic malignancies, especially in multiple myeloma (MM). Each cellular and non-cellular component of the TM...
Nano-CRISPR extracellular vesicle sensing system for longitudinal tumor monitoring
Detection of reliable biomarkers that represent treatment response and drug resistance remains a major clinical challenge for ovarian cancer. Extracellular vesicles (EVs) represent...
Engineering in vivo half-life extension of a novel mammalian asparaginase to increase feasibility of pan-cancer therapy
Project Summary: The goal of this proposal is to extensively broaden the clinical applications of the unique anti-cancer biologic drug L-asparaginase (ASNase) by developing a longe...
Spatial protein-protein interaction networks in situ by multiplexed proximity ligation
Patients with non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) gene mutations have been successfully treated with EGFR tyrosine kinase inhibitors (EG...
A platform for multi-modal single nucleus spatial genomics for molecular tumor analysis
Project Summary Tumors reside within a complex multicellular ecosystem comprised of malignant and non- malignant cells, where interacting cells and molecules are organized in space...
Development of A Directed Evolution Platform for RNA Methyltransferases.
PROJECT SUMMARY N6-methyladenosine (m6A) is one of the most abundant chemical modifications in human messenger RNA (mRNA). m6A in mRNA is dynamically regulated by the effector prot...
Targeting the DNA Damage Response sensor Replication Protein A for first inclass cancer therapy
Abstract The DNA Damage Response (DDR) is an integrated network of DNA repair and cell signaling pathways that are critical towards maintaining genomic stability. Targeting the DDR...
The Development of Radiolabeled PSMA Agent with Low Salivary Gland Uptake
Project Abstract Widely overexpressed in prostate cancer tissues, Prostate Specific Membrane Antigen (PSMA) has become an attractive target for both imaging and radionuclide-based...
Highly stable mini-circRNA vaccine with maximally activated and long-lasting T cells for HPV-related cancer combination immunotherapy
Human papillomavirus (HPV) is responsible for a large proportion of global cancer cases, including head and neck, cervical and anal cancers, among others. HPV-related cancers are c...
Develop and validate demineralized bone paper-based human bone metabolic and senolytic assays
Project Summary Bone metastasis is a major cause of morbidity and mortality in cancer survivors. It is closely linked to advanced skeletal aging, which is driven by the accumulatio...
A Phase 1 Study of Patient-Derived Multi-Tumor-Associated Antigen Specific T Cells (MT-601) Administered to Patients with Relapsed Non-Hodgkin Lymphoma
ABSTRACT This application presents MT-601, a novel multi-tumor associated antigen (mTAA)-specific T cell product for the treatment of Non-Hodgkin’s Lymphoma (NHL). NHL is the most...
Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (VA-ACCERT) Center
Overall: Project Summary The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (VA-ACCERT) Center is an academic-public partnership between an inte...
The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (VA-ACCERT) Center
ADMINISTRATIVE CORE: PROJECT SUMMARY The Administrative Core for the Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (VA-ACCERT) Center will prov...
The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (ACCERT) Center
RESEARCH METHODS, MEASURES, AND DATA MANAGEMENT (RMMDM) CORE: PROJECT SUMMARY Evaluations of interventions that target the numerous social drivers of health (SDOH) factors experien...
The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (ACCERT) Center
SOCIAL DRIVERS OF HEALTH (SDOH) RESEARCH PROJECT: PROJECT SUMMARY In the US, individuals and families living in poverty are placed at increased risk for cancer. Living in an under-...
The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (VA-ACCERT) Center
COMMUNITY RESPONSIVE RESEARCH PROJECTS: PROJECT SUMMARY The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (VA-ACCERT) Center will support four...
A PROGNOSTIC ASSAY FOR METASTATIC CLEAR CELL RENAL CELL CARCINOMA
ABSTRACT An estimated 79,000 Americans were diagnosed with renal carcinoma in 2022 and approximately 13,920 died, primarily as a result of metastasis. First line treatment involves...