Protein Phosphorylation in Health and Disease

Program Director/Principal Investigator (Last, First, Middle): Tagliabracci, V.S./Yaffe, M. Protein phosphorylation plays a vital role in cellular communication, regulating cellular state and activity. It is a dynamic process controlled by kinases and phosphatases, which are precisely regulated in healthy cells but

dysregulated in diseases like diabetes, inflammation, and cancer. The study of protein phosphorylation and its signaling function is a rapidly advancing field, driving methodological and conceptual advancements and contributing to therapeutic development. In cancer research, protein kinases are frequently deregulated and

have gained significant attention from the pharmaceutical industry. Many FDA-approved cancer drugs target kinases, and numerous kinase inhibitors are currently in development. This clinical relevance establishes an exciting connection with translational science. To support the advancement of knowledge in this field, we seek funding to enable the attendance of trainees,

junior faculty, and underrepresented groups at the 2024 FASEB Summer Research conference on Protein phosphorylation in healh and disease. This biennial conference, which began in 1983, serves as a key interdisciplinary gathering, bringing together scientists with diverse expertise. It focuses specifically on the

biochemical mechanisms and fundamental principles of phosphorylation, setting it apart from other conferences that focus on signaling networks and systems approaches. The FASEB meeting has a rich history of announcing breakthroughs and aims to enhance and disseminate knowledge that can lead to improved therapies targeting abnormal kinase activity and protein phosphorylation

in human diseases. The 2024 FASEB Science Research Conference on Protein phosphorylation in health and disease will highlight cutting-edge discoveries in the field. By uniting disciplines such as structural biology, biochemistry, systems biology, chemical biology, protein engineering, and medicine, the conference will foster

the interchange of ideas and stimulate new research directions. Our objectives include promoting communication, collaboration, and career advancement for diverse scientists in the field. Ultimately, we aim to advance our understanding of the molecular mechanisms governing vital biological processes and identify critical targets for the diagnosis, prevention, treatment, and cure of human

diseases. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page