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20,252 grants found
Showing 4,001 – 4,020 of 20,252 grants
Research Project 1 PDAC Molecular Subtypes Contribute to Cancer Health Disparities
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that is refractory to current treatment strategies due in part to adaptive mechanisms of chemoresistance...
Myeloid cell-selective, oligonucleotide-based STAT3 inhibition combined with total marrow and lymphoid irradiation for immunotherapy of acute myeloid leukemia
PROJECT SUMMARY There has been little or no long-term improvement in outcomes for patients with treatment-refractory acute myeloid leukemia (AML). The recently developed image-guid...
Targeting GSK3B in refractory B-cell malignancies
Abstract GSK3E functions as essential negative regulator of E-catenin, while E-catenin accumulation represents a central oncogenic driver in cancer. In solid tumors, E-catenin form...
Tunneling Nanotube Inhibitors for Cancer Immunotherapy
ABSTRACT In a recent study published in Nature Nanotechnology, we demonstrated that cancer cells form physical nanoscales tentacles (nanotubes) to connect with and harvest mitochon...
Tunneling Nanotube Inhibitors for Cancer Immunotherapy
Project Summary Prostate cancer (PCa) is the second-most common cancer in American men1. Early diagnosis and advances in therapeutic strategies have significantly improved overall...
Investigating nanotube-mediated mitochondria transfer and inhibitor effects in cancer-immune cell interactions across 2D and 3D models
Project Summary/Abstracts This supplementary project aims to uncover the mechanisms and implications of mitochondria transfer between immune cells and cancer cells via tunneling na...
United for Health Equity - Living PDX Program (U4HELPP)
PROJECT SUMMARY/ABSTRACT – OVERALL The United for Health Equity-Living PDX Program (U4HELPP) seeks to develop >500 new patient-derived xenograft (PDX) models of cancers originat...
Targeting myeloid cells to increase efficacy of immunotherapy against brain tumors.
PROJECT SUMMARY The proposed research career development program seeks to investigate the mechanism by which myeloid cells in brain tumors become immunosuppressive, preventing the...
Development of a panel of multiplex biomarkers for the early detection of pancreatic ductal adenocarcinoma and high-risk lesions
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with an overall 5-year survival of 11%. Due to its asymptomatic nature and lack of methods for early d...
Tunneling Nanotube Inhibitors for Cancer Immunotherapy
ABSTRACT In a recent study published in Nature Nanotechnology, we demonstrated that cancer cells form physical nanoscales tentacles (nanotubes) to connect with and harvest mitochon...
Analyzing Patient-Level Data in a Breast Cancer Clinical Trial
ABSTRACT Most women treated for breast cancer will experience some form of drug-related toxicity and subsequent impairments in Health-related Quality of Life (HRQOL), yet toxicity...
Development of a panel of multiplex biomarkers for the early detection of pancreatic ductal adenocarcinoma and high-risk lesions
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with an overall 5-year survival of 11%. Due to its asymptomatic nature and lack of methods for early d...
Administrative Core
PROJECT SUMMARY / ABSTRACT – ADMINISTRATIVE CORE The Administrative Core (AC) will provide organizational infrastructure for Virginia Commonwealth University - Massey Cancer Center...
PDX Core
PROJECT SUMMARY / ABSTRACT U4HELPP PDX CORE A profound limitation to personalized approaches for therapeutic development in cancer is the lack of relevant patient derived models in...
Research Project 2 Proteogenomic-guided therapeutic targeting of breast cancer patient-derived xenograft metastases
Project Summary/Abstract Breast cancer is diagnosed in 1-of-8 women and is the most common type of cancer diagnosed at VCU. There are several genetically distinct subtypes of human...
Targeting myeloid cells to increase efficacy of immunotherapy against brain tumors.
PROJECT SUMMARY The proposed research career development program seeks to investigate the mechanism by which myeloid cells in brain tumors become immunosuppressive, preventing the...
PDX Core
PROJECT SUMMARY / ABSTRACT U4HELPP PDX CORE A profound limitation to personalized approaches for therapeutic development in cancer is the lack of relevant patient derived models in...
Noninvasive monitoring of therapeutic response to immune checkpoint inhibitors using circulating exosomes in non-small cell lung cancer
Summary/ Abstract: The emergence of immune checkpoint blockade (ICB) therapy has revolutionized the treatment for advanced cancers including lung cancer. Particularly, anti-PD-1/PD...
Estrogenic protection against colorectal cancer development in obesity
Project Summary Sporadic colorectal cancer (CRC), a subtype of CRC without family history but attributed to the presence of various risk factors, is the majority (~75%) of new CRC...
United for Health Equity - Living PDX Program (U4HELPP)
PROJECT SUMMARY/ABSTRACT – OVERALL The United for Health Equity-Living PDX Program (U4HELPP) seeks to develop >500 new patient-derived xenograft (PDX) models of cancers originat...