PDX Core

Funder	NATIONAL CANCER INSTITUTE
Recipient Organization	Virginia Commonwealth University
Country	United States
Start Date	Jul 19, 2023
End Date	Jun 30, 2028
Duration	1,808 days
Number of Grantees	1
Roles	Principal Investigator
Data Source	NIH (US)
Grant ID	`10890847`

Grant Description

PROJECT SUMMARY / ABSTRACT U4HELPP PDX CORE A profound limitation to personalized approaches for therapeutic development in cancer is the lack of relevant patient derived models in all cancer types, especially those from underrepresented minority groups with more aggressive, recalcitrant and/or advanced clinical stages. The overall objectives of United for Health Equity in

Living PDX Program (U4HELPP) will be to increase diverse representation and study of racial/ethnic minority populations through development and investigations on more racial/ethnically diverse patient-derived xenograft models (PDX) to advance cancer health disparity research. The U4HELPP PDX Core will serve as a central point

for patient-derived viable tumor tissue harvest and expansion to fully support Research Projects 1 & 2 and Pilot Project and Trans-network Activities Core. The U4HELPP PDX Core will also serve as a central database of these specimens with clinical and molecular characteristics, including ancestry, of each cancer subtype, linked

to molecular genomics.