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20,252 grants found
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The Thromboxane-Prostanoid Receptor in Radiation-Induced Pulmonary Fibrosis
Project Summary: Radiation induced lung injury is a crucial dose-limiting factor in patients receiving thoracic radiotherapy, affecting a significant proportion of patients even wi...
dMRI-guided pre-operative planning for supra-total resection of high-grade gliomas
ABSTRACT High-grade gliomas (HGGs) are the most common primary brain malignancy in adults associated with very poor survival rates despite various treatments. Surgery is the curren...
The telomere biomarker as a tool to inform decision-making for aggressive salvage therapy in men with rising PSA post prostatectomy
Men with biochemical recurrence after prostatectomy receiving salvage radiation (RT) may benefit from added anti-androgen therapy (AAT) by decreasing their likelihood of progressin...
Elucidating the Consequences of Chromosome 3 Arm Aneuploidies in Squamous Cell Carcinoma
PROJECT SUMMARY Aneuploidy, the gain or loss of whole chromosomes or chromosome arms, is a near-universal feature of cancer. However, the role of aneuploidy in tumor pathogenesis r...
The role of IL6-induced LAG3 as a resistance mechanism to PD1 blockade in NSCLC patients
PROJECT SUMMARY/ABSTRACT: Despite the landmark approval of anti-PD1 therapy for non-small cell lung cancer (NSCLC), the majority of patients still progress. Compensatory activation...
Hypertrophic adipocytes as biophysical mediators of breast cancer progression
PROJECT SUMMARY Over 40% of adult women in the U.S. are obese and obesity will soon overtake smoking as the leading risk factor for cancer. For breast cancer, obese women demonstra...
Molecular engineering and systematic evaluation of bispecific aptamers to develop potent and efficacious therapies for the immunomodulation of Non-Small Cell Lung Cancer
PROJECT SUMMARY Cancer is set to bypass cardiovascular disease as the number one cause of death in United States and it is a leading cause of death worldwide. Non-Small Cell Lung C...
Targeting Metabolic Vulnerabilities with Synergistic Therapeutic Agents for Treatment of Metastatic Castration-Resistant Prostate Cancer.
PROJECT SUMMARY Broad Impact: Prostate cancer (PCa) is the most commonly diagnosed cancer in American men and in 2022 alone will result in the death of over 34,000 men. PCa mortali...
Targeting Metabolic Vulnerabilities with Synergistic Therapeutic Agents for Treatment of Metastatic Castration-Resistant Prostate Cancer.
PROJECT SUMMARY Broad Impact: Prostate cancer (PCa) is the most commonly diagnosed cancer in American men and in 2022 alone will result in the death of over 34,000 men. PCa mortali...
Hypertrophic adipocytes as biophysical mediators of breast cancer progression
PROJECT SUMMARY Over 40% of adult women in the U.S. are obese and obesity will soon overtake smoking as the leading risk factor for cancer. For breast cancer, obese women demonstra...
Molecular engineering and systematic evaluation of bispecific aptamers to develop potent and efficacious therapies for the immunomodulation of Non-Small Cell Lung Cancer
PROJECT SUMMARY Cancer is set to bypass cardiovascular disease as the number one cause of death in United States and it is a leading cause of death worldwide. Non-Small Cell Lung C...
Elucidating the Consequences of Chromosome 3 Arm Aneuploidies in Squamous Cell Carcinoma
PROJECT SUMMARY Aneuploidy, the gain or loss of whole chromosomes or chromosome arms, is a near-universal feature of cancer. However, the role of aneuploidy in tumor pathogenesis r...
The role of IL6-induced LAG3 as a resistance mechanism to PD1 blockade in NSCLC patients
PROJECT SUMMARY/ABSTRACT: Despite the landmark approval of anti-PD1 therapy for non-small cell lung cancer (NSCLC), the majority of patients still progress. Compensatory activation...
Examining Early Life Risk Factors and Patterns of Screening for Early-Onset Colorectal Cancer
PROJECT SUMMARY/ABSTRACT In the United States (US), the incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer (CRC) diagnosed among individuals
Examining Early Life Risk Factors and Patterns of Screening for Early-Onset Colorectal Cancer
PROJECT SUMMARY/ABSTRACT In the United States (US), the incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer (CRC) diagnosed among individuals
MASTER Scaffolds for Rapid, Single-Step Manufacture and Prototyping of CAR-T cells
PROJECT SUMMARY Despite the unprecedented clinical success of chimeric antigen receptor (CAR) T cell therapy, its widespread application is limited by lengthy and labor-intensive e...
Integration of Immunology and Microbiology into Molecular Pathological Epidemiology of Colorectal Cancer
Summary Colorectal cancer is a heterogenous disease influenced by somatic mutations, microbiota, host immunity, and risk factor exposures, necessitating integrative research approa...
Integration of Immunology and Microbiology into Molecular Pathological Epidemiology of Colorectal Cancer
Summary Colorectal cancer is a heterogenous disease influenced by somatic mutations, microbiota, host immunity, and risk factor exposures, necessitating integrative research approa...
In vivo prime editing for precision cancer mouse models
Project Summary/Abstract Cancer genomic studies have identified a large number of mutations, including point mutations, insertions/deletions (indels), and structural variants in co...
In vivo prime editing for precision cancer mouse models
Project Summary/Abstract Cancer genomic studies have identified a large number of mutations, including point mutations, insertions/deletions (indels), and structural variants in co...