Browse All Grants
20,252 grants found
Showing 241 – 260 of 20,252 grants
Administrative Core
PROJECT SUMMARY/ABSTRACT - ADMINISTRATIVE CORE The overall objective of the Administrative Core is to manage all pertinent administrative, financial, and operational needs within t...
Project 1-Combination Immunotherapy with Radioligned Therapy for Metastatic Prostate Cancer
PROJECT SUMMARY/ABSTRACT - PROJECT 1 (FONG): COMBINATION IMMUNOTHERAPY WITH RADIOLIGAND THERAPY FOR METASTATIC PROSTATE CANCER Immune checkpoint inhibitors (ICI) have limited singl...
Project 2 - Investigating Clinical and Biological Implications of a Novel Hypermethylated Subtype of Metastatic Castration Resistant Prostate Cancer (mCRPC)
PROJECT SUMMARY/ABSTRACT – PROJECT 2 (SMALL): INVESTIGATING CLINICAL AND BIOLOGICAL IMPLICATIONS OF A NOVEL HYPERMETHYLATED SUBTYPE OF METASTATIC CASTRATION RESISTANT PROSTATE CANC...
Multidisciplinary Training in Gastrointestinal Cancers
PROJECT SUMMARY Gastrointestinal (GI) cancers, which include malignancies of the esophagus, stomach, pancreas, colorectum, small intestine, and liver, constitute the plurality of c...
SPORE in Prostate Cancer
Overall Project Summary/Abstract Prostate cancer has become the most frequently diagnosed cancer in men in the United States (US) and a major cause of cancer morbidity and mortalit...
Administrative Core
Project Summary/Abstract: The Administrative Core is responsible for the managerial oversight of all Johns Hopkins Prostate SPORE Program activities. In addition, the Core continue...
Project 1: Combined Suppression of MYC as therapy for CRPC: the COSMYC trial
PROJECT 1 – PROJECT SUMMARY Prostate cancer cells (PCa) are highly adaptable in response to the tumor microenvironment. In response to chronic exposure to a low testosterone enviro...
Project 2: Dual Targeting of B7-H3 in mCRPC
PROJECT 2 – PROJECT SUMMARY Immune-checkpoint blockade has resulted in unprecedented treatment advances in multiple tumor types, despite yielding modest results in prostate cancer...
Project 3: Induction of synthetic lethality with combined DNMT and PARP inhibition
PROJECT SUMMARY Recent data have shown that PARP inhibitors are an effective therapeutic strategy for DNA repair-deficient metastatic castration-resistant prostate cancer (mCRPC)....
Biospecimen Core
Project Summary/Abstract: The primary goal of the Biospecimen/Pathology Core B is to facilitate translational research related to prostate tissue-based studies. The major functions...
Biostatistics Core
CORE C: Biostatistics/Bioinformatics Core PROJECT SUMMARY/ABSTRACT The Biostatistics and Bioinformatics Core (Core C) provides support to the 3 primary projects, and Career Enhance...
Developmental Research Program
Project Summary/Abstract The Developmental Research Program (DRP) is a special feature of the SPORE grant that allows sponsored institutions to fund important new pilot projects wi...
Career Enhancement Program
Project Summary/Abstract: The Career Enhancement Program (CEP) is a special feature of the SPORE grant which allows sponsored institutions to support junior faculty or established...
Construction of A Lung Cancer Preclinical Model Cross-comparison Platform
Project Summary Preclinical models of lung cancer are essential tools for researchers to understand cancer biology and develop therapeutic strategies. Choosing the most cost-effect...
Enhancing accrual and diversity across gynecologic and solid tumor trials
PROJECT SUMMARY/ABSTRACT My clinical research program focuses on improving the lives of all women with gynecologic malignancies. I serve as the lead for the clinical trials program...
Novel enhancement of antibody therapy through NOD2 activation
PROJECT SUMMARY Our long-term objective is to understand the expression and function of monocyte/macrophage Fcγ receptors with a goal of improving antibody-based therapies for dise...
Improving the Processes around Approval, Accrual and Translational Research in Cancer Prevention Trials
ABSTRACT The central goal of this R50 Clinician Scientist Award application is to establish and refine processes that facilitate clinical trials in cancer interception at The Unive...
Epigenetics, DNA repair and Genomics (EDGe) Training Program in Cancer
Here we propose a new Epigenetics, DNA repair and Genomics (EDGe) Training Program in Cancer to support 4 pre-doctoral students per year. EDGe will take advantage of a thematic int...
Multi-Modality Optical Molecular Imaging System for Preclinical Cancer Models
Project Abstract With the advent of fluorescence probes targeting specific cellular and subcellular events, the role of fluorescent imaging in preclinical arena is getting rapidly...
Molecular mechanism of INAFM2 in metastasis
PROJECT ABSTRACT Metastasis is the major cause of mortality in cancer patients and accounts for about 90% of cancer deaths, which has not changed in the past 50-years. This indicat...