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20,252 grants found
Showing 201 – 220 of 20,252 grants
Development of a Novel Aqueous Humor-Based Multiplex Assay for Uveal Melanoma Metastatic Risk Prediction
Project Summary Uveal melanoma (UM) is a prevalent intraocular cancer, with approximately 3,000 new cases annually and an estimated total of 60,000-70,000 affected individuals in t...
Project 1
PROJECT SUMMARY/ABSTRACT For multiple subtypes of breast cancer, Black patients endure poorer outcomes than White patients. There are many contributing factors, including socioecon...
Impact of dietary lipids on pancreas cancer initiation and progression
PROJECT SUMMARY Despite advances in cancer treatment, the five-year survival rate for pancreatic ductal adenocarcinoma (PDA) is 12%. Obesity has been linked to PDA risk epidemiolog...
Advancing novel cancer preventive and therapeutic strategies across the modern NCI clinical trial networks
PROJECT SUMMARY/ABSTRACT Guided by my 16-years of experience and leadership in the NCI-sponsored clinical trial networks (NCI-CTNs), this R50 Research Specialist award offers criti...
Longitudinal assessment of the role of interoception in chemotherapy-induced peripheral neuropathy (CIPN) along the cancer chemotherapy continuum
PROJECT SUMMARY/ABSTRACT Chemotherapy-induced peripheral neuropathy (CIPN) is a severe dose-limiting toxicity that affects over 65% of patients receiving taxane- or platinum-based...
Theranostic DLL3/PSMA-bi-specific CAR-T cells for prostate cancer therapy
SUMMARY Our overarching goal is to develop a novel theranostic prostate-cancer-specific CAR-T cell paradigm that will allow for successful targeting of antigen-heterogeneous neuroe...
Development of a highly sensitive DNA hypermethylation-based kit to identify Barrett's esophagus patients at high risk of progressing to esophageal adenocarcinoma
Summary The incidence of esophageal adenocarcinoma (EAC) has increased 600-700% in North America since the 1980s. EAC only has 18-22% of an overall 5-year survival rate because mos...
Inclusion of Diverse and Medically Underserved Populations in the Design and Implementation of the PREMMplus Patient-Facing App
Project Summary/Abstract The increasing use of genetic testing and the development of syndrome-specific risk models has transformed hereditary cancer risk assessment. We were funde...
AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation
Project Summary Abstract Electronic cigarette (e-cigarette) use among adolescents is an emerging public health problem. In 2020, 19.5% of high school students and 4.7% of middle sc...
SBIR PHASE II, TOPIC 431: AUTOMATIC TREATMENT PLANNING OF CERVICAL CANCER HIGH-DOSE RATE BRACHYTHERPAY FOR LOW-RESOURCE SETTINGS.
Cervical cancer is a major disease globally and 85% of the cancer burden occurs in low- and middle-income countries. Standard of care is external-beam radiotherapy with high dose-r...
Testing Oral Nicotine Pouches to Reduce Smoking-Related Cancer Disparities in Appalachia
PROJECT ABSTRACT Rural Appalachian counties have the highest cancer incidence and mortality rates in the United States (US). While most cancer disparities are narrowing between App...
A Motivation-Based Adolescent Vaping Typology to Inform Cessation Interventions
PROJECT SUMMARY/ABSTRACT Since the introduction of e-cigarettes in the U.S. in 2007, there has been a dramatic increase in the prevalence of e-cigarette use among adolescents. Thes...
ComPASS Health Equity Research Hub at Yale
ABSTRACT The Community Partnerships to Advance Science for Society (ComPASS) Health Equity Research Hub at Yale (Yale ComPASS Hub) will support select community-led health equity s...
Phase I Clinical Testing of a First-in-Class Therapy against Metastatic Cancer
SUMMARY Metastatic disease is responsible for ~90% of cancer deaths and is the primary determinant in the life-limiting aspect of cancer. One validated driver of metastasis is miRN...
The SHHare Community Project: The Shared Hub for Health Action Research and Equity in Community-led Interventions
PROJECT SUMMARY/ABSTRACT Structural determinants of health are societal structures and macro-level policies that lead to key exposures, such as racial discrimination and disparate...
Advancing Proteomics Technologies for Cancer Research
Project Summary I am the Technical Director of the Proteomics and Macromolecular Crystallography Shared Resource (PMCSR) at the Herbert Irving Comprehensive Cancer Center (HICCC),...
Core A: Curation and Statistical Analysis Core
CORE A ABSTRACT Curation and Statistical Analysis Core Core Director: Kathy Panageas (MSK) The Curation and Statistical Analysis Core will be co-led by Drs. Katherine Panageas and...
Core B: Molecular Pathology and Bioinformatics Core
CORE B ABSTRACT Molecular Pathology and Bioinformatics Core Core Director: Michael Berger, PhD (MSK) The Molecular Pathology and Bioinformatics Core will work closely with all Proj...
Skin cancer on social media: Analyzing current communications, modeling diffusion potential, and developing innovative prevention-focused messages
Project Abstract Exposure to ultraviolet (UV) light between the ages of 15-20-years is the most important etiological factor in skin cancer, yet adolescents and young adults (AYAs)...
Adaptation and Testing of an Evidence-Based Sexual Health Communication Skills Training Intervention for Patients with Prostate Cancer
Prostate cancer (PCa) is the most common non-cutaneous cancer in U.S. men and causes sexual dysfunction in up to 90% of patients. Sexual dysfunction is associated with long-term re...