Core B: Molecular Pathology and Bioinformatics Core

CORE B ABSTRACT Molecular Pathology and Bioinformatics Core Core Director: Michael Berger, PhD (MSK) The Molecular Pathology and Bioinformatics Core will work closely with all Project teams to coordinate the procurement and analysis of patient-derived tumor and matched normal tissue prioritized for further

characterization to fulfill the Research Aims. Biospecimens from selected patients will be obtained from participating AACR GENIE sites and characterized centrally by the Core. Digital pathology imaging and nucleic acid extraction will be performed from FFPE tissue specimens using standardized protocols. Comprehensive

genomic platforms, including whole exome sequencing and RNA-Seq, will be run under the direct supervision of the Core Director to enable deeper, multi-omic characterization of samples previously tested using targeted DNA panels. State-of-the-art bioinformatics pipelines will be used to produce and disseminate results to Project

teams, and Core members will collaborate with each Project to provide customized analytics support directed to the individual Aims.