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20,252 grants found
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Targeting a Novel Pocket on ITGAV
Project Summary. Cancer deaths remain at an all-time high in the United States leaving an urgent clinical need to develop novel therapeutic strategies to help patients. The lack of...
Differentiation and function of transitional monocytes in cancer metastasis to the lung
Project Summary/Abstract Cancer metastasis occurs when cancer cells spread to distal organs from their site of origin, and it is the leading cause of death in patients with solid c...
Differentiation and function of transitional monocytes in cancer metastasis to the lung
Project Summary/Abstract Cancer metastasis occurs when cancer cells spread to distal organs from their site of origin, and it is the leading cause of death in patients with solid c...
FY232 FACILITIES TO G-B1073 MOLD REMEDIATION
Building 1073 is a repository for the Natural Products Group and Division of Cancer Treatment and Diagnosis (DCTD). It houses approximately thirty-three LN2 Freezers as well as wal...
FY23 TASK ORDER H - 126361 WEDGEWOOD SUITE M & N EXPANSION
Suites H and K at 4600 Wedgewood Boulevard houses the NCI-F Central Repository. LBR has finalized leases with the landlord to secure the adjacent suites M and N and expand the Cent...
THE COST PLUS FIXED FEE (CPFF) TO TO REFURBISH AND IMPROVE NCI FREDERICK INFRASTRUCTURE WILL HAVE A BASE AND THREE (3) OPTIONS.
The Advanced Technology Research Facility (ATRF) was completed in 2013. The existing ATRF Data Center is running out of rack space for additional required compute and storage resou...
FY23 FACILITIES TO F
This project will repurpose exiting freezer B1403 at the ATRF to house a new crypo microscope. Walls will be constructed within B1403 creating an L-shaped freezer room and a separa...
FY23 TASK ORDER E - 126330 B320 TRAILER
The purpose of this project is to replace the deteriorating admin Trailer 320 with a new admin trailer that accommodates both the square footage of existing Trailer 320 (1,430 GSF)...
Low-Cost, Single-Use Trans-Nasal Cryotherapy Device for Low-Resource Settings
PROJECT SUMMARY/ABSTRACT Esophageal cancer is an aggressive disease with a five-year survival rate below 20 percent. The incidence of this cancer has increased dramatically over th...
Unraveling Neural Circuitry in Peripheral Cancer Pathogenesis: From Local Innervation to Systemic Influences
Project Summary The complex processes orchestrating cancer pathogenesis remain incompletely understood. Though most studies have focused on understanding the genetic and epigenetic...
PHARMACOKINETIC AND ORAL BIOAVAILABILITY STUDIES IN RATS
The purpose of this task order is to identify suitable formulations for administration of potential drug candidates to rats for early pharmacokinetic studies and to characterize th...
Does Tobacco Social Media Marketing Alter Adolescent Risk Perceptions and Use? Longitudinal Data-Adaptive Estimators and Causal Inference to Enhance Understanding
Project Summary Youth trajectories of tobacco use are of critical importance in the future of public health. Most tobacco use begins in adolescence and adolescents are particularly...
Development of a Wearable Fluorescence Imaging Device for IntraoperativeIdentification of Brain Tumors
ABSTRACT Approximately 700,000 people in the United States are diagnosed with a primary brain tumor. Of these, malignant gliomas (MGs) account for approximately 40% of all intracra...
Chromosomal aberration detection in FFPE tissue using proximity ligation sequencing
ABSTRACT The detection of chromosomal aberrations is a frontline diagnostic for the spectrum of blood neoplasms. Chromosomal aberrations, such as translocations, inversions, deleti...
Optimizing immunoradiotherapy for HNSCC
Project Summary Head and neck squamous cell carcinoma (HNSCC) is driven by tobacco, ethanol and other carcinogens as well as oncogenic human papilloma virus (HPV). In particular, H...
Chromosomal aberration detection in FFPE tissue using proximity ligation sequencing
ABSTRACT The detection of chromosomal aberrations is a frontline diagnostic for the spectrum of blood neoplasms. Chromosomal aberrations, such as translocations, inversions, deleti...
Does Tobacco Social Media Marketing Alter Adolescent Risk Perceptions and Use? Longitudinal Data-Adaptive Estimators and Causal Inference to Enhance Understanding
Project Summary Youth trajectories of tobacco use are of critical importance in the future of public health. Most tobacco use begins in adolescence and adolescents are particularly...
Therapeutic modulation of a proteomic HCC risk signature with statins in patients with liver cirrhosis
Hepatocellular carcinoma (HCC) is a major cirrhosis complication producing an alarming rise in mortality. The prognosis for HCC is poor due to extremely high recurrence rate even a...
Optimizing immunoradiotherapy for HNSCC
Project Summary Head and neck squamous cell carcinoma (HNSCC) is driven by tobacco, ethanol and other carcinogens as well as oncogenic human papilloma virus (HPV). In particular, H...
Therapeutic modulation of a proteomic HCC risk signature with statins in patients with liver cirrhosis
Hepatocellular carcinoma (HCC) is a major cirrhosis complication producing an alarming rise in mortality. The prognosis for HCC is poor due to extremely high recurrence rate even a...