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21,042 grants found
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Nicotinic Acetylcholine Receptors nAChRs in Prostate and Colon Cell Cancer: pharmacology, mechanism, cellular (mal)function
Nicotinic acetylcholine receptors (nAChRs) are transmembrane ligand gated ion channels composed of five subunits and encoded by 16 genes. Depending on the subunit composition nAChR...
Nano bio-responsive systems designed to avoid staphylococcal colonization of implant interfaces
Antimicrobial resistance (AMR) is responsible for 25,000 deaths per year in the EU and costs EUR 1.5 billion annually.Methicillin-sensitive Staphylococcus aureus (MSSA), Methicilli...
Study of the role of mitophagy and lysosomal biogenesis in COX deficiency: a new model for drug discovery
Mutations in COX15 are associated to cytochrome c oxidase (COX) deficiency (OMIM: 220110), a mitochondrial disease characterized by inefficient energy production due to the accumul...
Quantifying the impact of climate change on orchid mycorrhizal symbiosis in Mediterranean biodiversity hotspots
Compounded by habitat fragmentation and the pervasive impact of climate change, biodiversity, particularly in global biodiversity hotspots, faces an uncertain future.Orchids, among...
Exploring the underlying mechanIsms of partial leptin reduction towards a non-invasive obesity therapy
Leptin regulates energy balance by functioning as a “satiety signal”. When identified 26-years ago, expectations were high that leptin therapies could be used for the treatment of...
MetaCil: Unveiling the molecular interplay between primary cilia and metabolism in cancer
The primary cilium (PC), a ubiquitous microtubule (MT)-based organelle that protrudes from the apical surface of most human cells, is essential for transducing signals required for...
Friends or foes? The role of Biofilm microbiomes in industrial anaerobic membrane bioreactors to MAXimise bioenergy production
Transforming the European Union into a competitive low-carbon economy by 2050 requires the industry sector to continue implementing energy-efficient processes, especially for the v...
Analysis and prediction of submarine dune dynamics
Submarine dunes pose a significant risk for offshore activities in coastal areas, especially for the growing development of European renewable marine energy. Their evolution is sti...
gender CLImate Migration: innOvatiVe European Union socio-legal avenues
The overall aim of this fellowship is to provide a comprehensive and innovative socio-legal analysis of climate change-induced migration in the EU from a gender perspective.The mig...
Private Law and the Energy Commons
PLEC is the first to examine how the ‘Energy Commons’ wish to regulate themselves, where national private law poses unnecessary obstacles to these wishes, and how such obstacles co...
Analyzing emerging patterns of mortality through lifespan inequalities on a global scale
Most countries experienced major increases in life expectancy in the second half of the 20th century.This progress has meant that people are living longer on average and, at the sa...
Area-specific transcriptional dynamics and plasticity of neocortical neurons
Cellular diversity in the nervous system determines the variety of circuits that set the framework for brain function.These different types of neurons emerge during pre- and post-n...
Rationalising Full Compensation of Non-Pecuniary Damages to Reconcile Equal Treatment and Personalisation
In the EU, full compensation of non-pecuniary damages remains fragmented and subjective, leading to unequal outcomes within jurisdictions. This is despite numerous attempts to redu...
Stretchable Transparent Microsupercapacitor from Nanodiamond Decorated Laser-Induced Graphene: Design and Demonstrator
Stretchable microsupercapacitors (MSCs) can operate in multiple mechanical distortions including stretching, bending, twisting, and compression. These mechanical adaptabilities are...
Mega-evolutionary dynamics of anurans
Adaptive radiation has been pointed out as the main force responsible for phenotypic and taxonomic diversity.Rapid phenotypic evolution and expansion in the morphospace tend to cea...
Fully RoHS Compliant Infrared Light Emitting Diodes Based on Novel Lead-free Quantum Dots
Infrared light-emitting diodes (IR-LEDs) serve a broad range of applications including fiber-optic communications, night vision as well as clinical diagnosis and biomedical imaging...
Hands for Autonomous aNd Dexterous grasping
The human hand is an incredibly complex system with a huge spectrum of functionality.Hands are essential not only to interact with different objects daily, but also necessary for s...
Adaptation of human brown adipose tissue to overnutrition
Brown adipose tissue (BAT) is a highly thermogenic tissue whose main function is to produce heat to maintain mammals body temperature. In humans, it has long been believed that BAT...
Controllably Biodegradable Conductors for Robotic Tactile Skins
BioConTact will engineer electrical conductors with a controllable biodegradability that are flexible, lightweight, scalable, and produced with readily available materials. The tun...
Targeting the purinergic system for disease-modification in epilepsy
Current epilepsy therapies, based on mediating excitation or inhibition, are ineffective in 30% of patients & have no impact on disease progression, demonstrating an urgent nee...