Adaptation of human brown adipose tissue to overnutrition

Brown adipose tissue (BAT) is a highly thermogenic tissue whose main function is to produce heat to maintain mammals body temperature. In humans, it has long been believed that BAT is either absent or irrelevant in adults.

However, a decade ago, several independent research groups confirmed the presence of metabolically active BAT in human adults. In rodents, BAT plays a key role in the adaptation to overfeeding, protecting murine from diet-induced obesity. Whether this phenomenon also occurs in humans is still unknown.

To date, technical limitations for in vivo human BAT assessment have precluded us from adequately studying it.The BATON study will first aim to develop a new method to accurately measure human BAT volume and thermogenic capacity in vivo. New approaches based on recent advances in human BAT metabolism (i.e.

BATs unique ability to burn its own intracellular triglycerides and the recently discovered, and unexpected, capacity of human BAT to be activated through 2 adrenergic receptor agonism) will be tested in a randomized cross-over study. Ten young healthy adults (18-30-years old, 5 men and 5 women, with a body mass index