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201,169 grants found
Showing 199,821 – 199,840 of 201,169 grants
Traumatic Brain Injury and Vascular Disease
Objective: Traumatic brain injury (TBI) is a common cause of morbidity and mortality in the veteran population. In the United States, there are an estimated 5.3 million people livi...
Host factors affecting susceptibility to Candida auris.
This VA Merit research project aims to define host factors associated with mucosal infection by an emerging multi-drug resistant human fungal pathogen, Candida auris. Most human fu...
A role and regulation of glucose responsive lipolysis in pancreatic beta cells
T2D is a major health problem for US veterans that imposes significant physical, financial, and emotional tolls. Thus, there is a strong and urgent need for an effective and widely...
mTOR-Mediated Desaturation of Fatty Acids in Hepatic Insulin Resistance.
Discharged members of the US Armed Services are at an increased risk of metabolic disease which is exemplified by the prevalence of type 2 diabetes mellitus (T2DM) affecting an est...
Toxicant Exposure Impacts Host-pathogen interactions within the Reproductive Tract
Project Summary Exposure to persistent environmental toxicants (such as dioxin) is a global problem, but disproportionately affects Veterans who were exposed dioxin derived from bu...
Defining Breath VOC Biomarkers to Improve Respiratory Health of Exposed Veterans
The goal of this resubmitted application is to define signature exhaled breath volatile organic compounds (VOCs) in veterans exposed to toxicants and to develop an effective portab...
Developing novel CRISPR/CasX editors to generate a CCR5/null immune system
The characterization of CRISPR/Cas as a method to edit genes that contribute to human diseases provides new opportunities for the development of innovative therapeutic approaches....
Foxp transcription factors in regulatory T cells
Regulatory T cells (Tregs) are critical for actively maintaining immune tolerance. The Foxp family of transcription factors is composed of four members; Foxp1, Foxp3 and Foxp4 are...
Exploring cyclic di-nucleotide signaling across the tree of life
Summary: Exploring cyclic di-nucleotide signaling across the tree of life All organisms utilize molecular regulatory mechanisms connecting external sensory systems to phenotypic ou...
Veterans Affairs - Translational Education and Mentoring (VA-TEAM) Center
Agencies that fund medical research are under increasing pressure to translate funded research projects to commercial entities. These commercial entities can obtain the necessary e...
Neural Substrates of Binge Drinking
Alcohol misuse is responsible for ~88,000 deaths annually and exerts an annual cost of ~$250 billion in the US. Binge drinking, which accounts for ~75% of these costs, is defined b...
Colon cancer nanotherapy targeting STRAP
Although activation of the Ras/Raf/MEK/ERK pathway is involved in cell growth, inhibition of apoptosis, induction in stem-like phenotype, and drug resistance, little is known about...
CMA: Network plasticity in acquired epileptogenesis
Project Summary/ Abstract: Temporal Lobe Epilepsy (TLE) is the most frequent type of post-traumatic epilepsy, causing significant morbidity in the veteran population. Approximatel...
Dynamics of protein kinase CK2 signaling in prostate cancer pathogenesis
Prostate cancer (PCa) is one of the major health issues for the aging Veterans population warranting investigations to further advance knowledge of the disease pathobiology and ben...
Preoptic/Hypothalamic Mechanisms of Sleep-Wake Regulation
ABSTRACT Chronic sleep disturbance is a frequent and challenging problem of human aging. In the US an estimated 39.6 million people including 8.5 million Veterans are aged 65 or ol...
CMA: Network plasticity in acquired epileptogenesis
Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults and a major source of disability in the veteran population as it is frequently caused by war-time head in...
Mechanism of Vascular Impairment in Neurocognitive Disorders
Vascular cognitive impairment and dementia (VCID) is the most common etiology of dementia in the elderly including veterans. Since proportion of the elderly population is progressi...
Red Blood Cells shuttle beta amyloid between brain and heart: implications for the pathogenesis and the progression of Alzheimer's and Cardiomyopathy
Abstract Alzheimer disease (AD) is the most frequent form of dementia causing a significant reduction of quality of life of affected patients. In the brains of AD patients, β-amylo...
A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos
Project Summary Physical inactivity is a public health priority for older Latinos with mild cognitive impairment (MCI). MCI, considered the pre-dementia stage of Alzheimer’s diseas...
A deubiquitination module controls Treg adaptation to tumor microenvironment
Project Summary: One of the recent advances in cancer treatment is the development of immunotherapy largely through targeting the checkpoint receptors. However, attempts at immunot...